Hypersynchrony in MEG spectral amplitude in prospectively-identified 6-month-old infants prenatally exposed to alcohol
Early identification of children who experience developmental delays due to prenatal alcohol exposure (PAE) remains a challenge for individuals who do not exhibit facial dysmorphia. It is well-established that children with PAE may still exhibit the cognitive and behavioral difficulties, and individ...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2018-01-01
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| Series: | NeuroImage: Clinical |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158217303170 |
| _version_ | 1818579317640134656 |
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| author | Julia M. Stephen Lucinda Flynn Danielle Kabella Megan Schendel Sandra Cano Daniel D. Savage William Rayburn Lawrence M. Leeman Jean Lowe Ludmila N. Bakhireva |
| author_facet | Julia M. Stephen Lucinda Flynn Danielle Kabella Megan Schendel Sandra Cano Daniel D. Savage William Rayburn Lawrence M. Leeman Jean Lowe Ludmila N. Bakhireva |
| author_sort | Julia M. Stephen |
| collection | DOAJ |
| description | Early identification of children who experience developmental delays due to prenatal alcohol exposure (PAE) remains a challenge for individuals who do not exhibit facial dysmorphia. It is well-established that children with PAE may still exhibit the cognitive and behavioral difficulties, and individuals without facial dysmorphia make up the majority of individuals affected by PAE. This study employed a prospective cohort design to capture alcohol consumption patterns during pregnancy and then followed the infants to 6months of age. Infants were assessed using magnetoencephalography to capture neurophysiological indicators of brain development and the Bayley Scales of Infant Development-III to measure behavioral development. To account for socioeconomic and family environmental factors, we employed a two-by-two design with pregnant women who were or were not using opioid maintenance therapy (OMT) and did or did not consume alcohol during pregnancy. Based on prior studies, we hypothesized that infants with PAE would exhibit broad increased spectral amplitude relative to non-PAE infants. We also hypothesized that the developmental shift from low to high frequency spectral amplitude would be delayed in infants with PAE relative to controls. Our results demonstrated broadband increased spectral amplitude, interpreted as hypersynchrony, in PAE infants with no significant interaction with OMT. Unlike prior EEG studies in neonates, our results indicate that this hypersynchrony was highly lateralized to left hemisphere and primarily focused in temporal/lateral frontal regions. Furthermore, there was a significant positive correlation between estimated number of drinks consumed during pregnancy and spectral amplitude revealing a dose-response effect of increased hypersynchrony corresponding to greater alcohol consumption. Contrary to our second hypothesis, we did not see a significant group difference in the contribution of low frequency to high frequency amplitude at 6months of age. These results provide new evidence that hypersynchrony, previously observed in neonates prenatally exposed to high levels of alcohol, persists until 6months of age and this measure is detectable with low to moderate exposure of alcohol with a dose-response effect. These results indicate that hypersynchrony may provide a sensitive early marker of prenatal alcohol exposure in infants up to 6months of age. Keywords: Prenatal alcohol exposure, Rest, Spectral amplitude, Magnetoencephalography, Infants |
| first_indexed | 2024-12-16T06:59:47Z |
| format | Article |
| id | doaj.art-e7a986e14de84f33a48cff14c1d019fc |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-12-16T06:59:47Z |
| publishDate | 2018-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-e7a986e14de84f33a48cff14c1d019fc2022-12-21T22:40:12ZengElsevierNeuroImage: Clinical2213-15822018-01-0117826834Hypersynchrony in MEG spectral amplitude in prospectively-identified 6-month-old infants prenatally exposed to alcoholJulia M. Stephen0Lucinda Flynn1Danielle Kabella2Megan Schendel3Sandra Cano4Daniel D. Savage5William Rayburn6Lawrence M. Leeman7Jean Lowe8Ludmila N. Bakhireva9The Mind Research Network and Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, USA; Corresponding author at: The Mind Research Network, 1101 Yale Blvd NE, Albuquerque, NM 87106, USA.The Mind Research Network and Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, USAThe Mind Research Network and Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, USAThe Mind Research Network and Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, USADepartment of Pharmacy Practice and Administrative Sciences, College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, NM, USADepartment of Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, NM, USA; Department of Pediatrics, University of New Mexico Health Sciences Center, Albuquerque, NM, USADepartment of Obstetrics and Gynecology, University of New Mexico Health Sciences Center, Albuquerque, NM, USADepartment of Obstetrics and Gynecology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA; Department of Family and Community Medicine, School of Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, USADepartment of Pediatrics, University of New Mexico Health Sciences Center, Albuquerque, NM, USADepartment of Pharmacy Practice and Administrative Sciences, College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, NM, USA; Department of Family and Community Medicine, School of Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, USAEarly identification of children who experience developmental delays due to prenatal alcohol exposure (PAE) remains a challenge for individuals who do not exhibit facial dysmorphia. It is well-established that children with PAE may still exhibit the cognitive and behavioral difficulties, and individuals without facial dysmorphia make up the majority of individuals affected by PAE. This study employed a prospective cohort design to capture alcohol consumption patterns during pregnancy and then followed the infants to 6months of age. Infants were assessed using magnetoencephalography to capture neurophysiological indicators of brain development and the Bayley Scales of Infant Development-III to measure behavioral development. To account for socioeconomic and family environmental factors, we employed a two-by-two design with pregnant women who were or were not using opioid maintenance therapy (OMT) and did or did not consume alcohol during pregnancy. Based on prior studies, we hypothesized that infants with PAE would exhibit broad increased spectral amplitude relative to non-PAE infants. We also hypothesized that the developmental shift from low to high frequency spectral amplitude would be delayed in infants with PAE relative to controls. Our results demonstrated broadband increased spectral amplitude, interpreted as hypersynchrony, in PAE infants with no significant interaction with OMT. Unlike prior EEG studies in neonates, our results indicate that this hypersynchrony was highly lateralized to left hemisphere and primarily focused in temporal/lateral frontal regions. Furthermore, there was a significant positive correlation between estimated number of drinks consumed during pregnancy and spectral amplitude revealing a dose-response effect of increased hypersynchrony corresponding to greater alcohol consumption. Contrary to our second hypothesis, we did not see a significant group difference in the contribution of low frequency to high frequency amplitude at 6months of age. These results provide new evidence that hypersynchrony, previously observed in neonates prenatally exposed to high levels of alcohol, persists until 6months of age and this measure is detectable with low to moderate exposure of alcohol with a dose-response effect. These results indicate that hypersynchrony may provide a sensitive early marker of prenatal alcohol exposure in infants up to 6months of age. Keywords: Prenatal alcohol exposure, Rest, Spectral amplitude, Magnetoencephalography, Infantshttp://www.sciencedirect.com/science/article/pii/S2213158217303170 |
| spellingShingle | Julia M. Stephen Lucinda Flynn Danielle Kabella Megan Schendel Sandra Cano Daniel D. Savage William Rayburn Lawrence M. Leeman Jean Lowe Ludmila N. Bakhireva Hypersynchrony in MEG spectral amplitude in prospectively-identified 6-month-old infants prenatally exposed to alcohol NeuroImage: Clinical |
| title | Hypersynchrony in MEG spectral amplitude in prospectively-identified 6-month-old infants prenatally exposed to alcohol |
| title_full | Hypersynchrony in MEG spectral amplitude in prospectively-identified 6-month-old infants prenatally exposed to alcohol |
| title_fullStr | Hypersynchrony in MEG spectral amplitude in prospectively-identified 6-month-old infants prenatally exposed to alcohol |
| title_full_unstemmed | Hypersynchrony in MEG spectral amplitude in prospectively-identified 6-month-old infants prenatally exposed to alcohol |
| title_short | Hypersynchrony in MEG spectral amplitude in prospectively-identified 6-month-old infants prenatally exposed to alcohol |
| title_sort | hypersynchrony in meg spectral amplitude in prospectively identified 6 month old infants prenatally exposed to alcohol |
| url | http://www.sciencedirect.com/science/article/pii/S2213158217303170 |
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