A Case of Fifteen Simultaneous Rectal Neuroendocrine Tumors and Endocrine Cell Micronests Resected by Both Endoscopic Treatments and Surgery
Case Report:A 65-year-old man without any symptoms received colonoscopy for cancer screening and underwent cold snare polypectomy (CSP) for a 3-mm rectal lesion at a local clinic. A histopathological examination revealed neuroendocrine tumor (NET) G1 with a positive margin. The patient was referred...
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| Format: | Article |
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Karger Publishers
2022-02-01
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| Series: | Case Reports in Gastroenterology |
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| Online Access: | https://www.karger.com/Article/FullText/521522 |
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| author | Hikaru Hashimoto Naohisa Yoshida Ken Inoue Reo Kobayashi Yuri Tomita Satoshi Sugino Osamu Dohi Ryohei Hirose Yutaka Inada Takaaki Murakami Yukiko Morinaga Mitsuo Kishimoto Yoshito Itoh |
| author_facet | Hikaru Hashimoto Naohisa Yoshida Ken Inoue Reo Kobayashi Yuri Tomita Satoshi Sugino Osamu Dohi Ryohei Hirose Yutaka Inada Takaaki Murakami Yukiko Morinaga Mitsuo Kishimoto Yoshito Itoh |
| author_sort | Hikaru Hashimoto |
| collection | DOAJ |
| description | Case Report:A 65-year-old man without any symptoms received colonoscopy for cancer screening and underwent cold snare polypectomy (CSP) for a 3-mm rectal lesion at a local clinic. A histopathological examination revealed neuroendocrine tumor (NET) G1 with a positive margin. The patient was referred to our hospital for further treatment. Then, the post-CSP scar was removed by endoscopic submucosal dissection (ESD), with a sufficient endoscopically normal margin. Histopathology showed 4 NETs and endocrine cell micronests (ECMs) distant from the post-CSP scar, with a positive lateral margin. We considered that the possibility of other NETs was high. Additional surgery was performed. After a histopathological examination, 11 NETs and ECMs were found in the whole rectum, without lymph node metastasis. The patient had no recurrence at 24 months after surgery. In the past 10 years, we have experienced 4 cases (including the present case) of multiple rectal NETs among 56 cases of rectal NETs of ≤10 mm (7.1%). None of our 4 cases showed any recurrence (follow-up period: 12–32 months).Conclusions:We herein report a case involving a patient with 15 rectal NETs and ECMs. We reviewed our experience with multiple rectal NETs, and the rate of multiple rectal NETs was 7.1%. Endoscopists should consider that multiple lesions may be present in cases of rectal NET and be aware that some cannot be detected endoscopically. |
| first_indexed | 2024-04-13T22:29:47Z |
| format | Article |
| id | doaj.art-e7aa440a8dc24a5098a5254586cc9a39 |
| institution | Directory Open Access Journal |
| issn | 1662-0631 |
| language | English |
| last_indexed | 2024-04-13T22:29:47Z |
| publishDate | 2022-02-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Gastroenterology |
| spelling | doaj.art-e7aa440a8dc24a5098a5254586cc9a392022-12-22T02:26:57ZengKarger PublishersCase Reports in Gastroenterology1662-06312022-02-01161374310.1159/000521522521522A Case of Fifteen Simultaneous Rectal Neuroendocrine Tumors and Endocrine Cell Micronests Resected by Both Endoscopic Treatments and SurgeryHikaru Hashimoto0https://orcid.org/0000-0002-7429-705XNaohisa Yoshida1https://orcid.org/0000-0001-6167-9705Ken Inoue2Reo Kobayashi3Yuri Tomita4Satoshi Sugino5Osamu Dohi6https://orcid.org/0000-0002-0498-0144Ryohei Hirose7Yutaka Inada8Takaaki Murakami9Yukiko Morinaga10Mitsuo Kishimoto11Yoshito Itoh12Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, JapanDepartment of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, JapanDepartment of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, JapanDepartment of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, JapanDepartment of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, JapanDepartment of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, JapanDepartment of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, JapanDepartment of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, JapanDepartment of Gastroenterology, Kyoto First Red Cross Hospital, Kyoto, JapanDepartment of Gastroenterology, Aiseikai Yamashina Hospital, Kyoto, JapanDepartment of Surgical Pathology, Kyoto Prefectural University of Medicine, Kyoto, JapanDepartment of Pathology, Kyoto City Hospital, Kyoto, JapanDepartment of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, JapanCase Report:A 65-year-old man without any symptoms received colonoscopy for cancer screening and underwent cold snare polypectomy (CSP) for a 3-mm rectal lesion at a local clinic. A histopathological examination revealed neuroendocrine tumor (NET) G1 with a positive margin. The patient was referred to our hospital for further treatment. Then, the post-CSP scar was removed by endoscopic submucosal dissection (ESD), with a sufficient endoscopically normal margin. Histopathology showed 4 NETs and endocrine cell micronests (ECMs) distant from the post-CSP scar, with a positive lateral margin. We considered that the possibility of other NETs was high. Additional surgery was performed. After a histopathological examination, 11 NETs and ECMs were found in the whole rectum, without lymph node metastasis. The patient had no recurrence at 24 months after surgery. In the past 10 years, we have experienced 4 cases (including the present case) of multiple rectal NETs among 56 cases of rectal NETs of ≤10 mm (7.1%). None of our 4 cases showed any recurrence (follow-up period: 12–32 months).Conclusions:We herein report a case involving a patient with 15 rectal NETs and ECMs. We reviewed our experience with multiple rectal NETs, and the rate of multiple rectal NETs was 7.1%. Endoscopists should consider that multiple lesions may be present in cases of rectal NET and be aware that some cannot be detected endoscopically.https://www.karger.com/Article/FullText/521522rectal neuroendocrine tumorendoscopic submucosal dissectionendocrine cell micronests |
| spellingShingle | Hikaru Hashimoto Naohisa Yoshida Ken Inoue Reo Kobayashi Yuri Tomita Satoshi Sugino Osamu Dohi Ryohei Hirose Yutaka Inada Takaaki Murakami Yukiko Morinaga Mitsuo Kishimoto Yoshito Itoh A Case of Fifteen Simultaneous Rectal Neuroendocrine Tumors and Endocrine Cell Micronests Resected by Both Endoscopic Treatments and Surgery Case Reports in Gastroenterology rectal neuroendocrine tumor endoscopic submucosal dissection endocrine cell micronests |
| title | A Case of Fifteen Simultaneous Rectal Neuroendocrine Tumors and Endocrine Cell Micronests Resected by Both Endoscopic Treatments and Surgery |
| title_full | A Case of Fifteen Simultaneous Rectal Neuroendocrine Tumors and Endocrine Cell Micronests Resected by Both Endoscopic Treatments and Surgery |
| title_fullStr | A Case of Fifteen Simultaneous Rectal Neuroendocrine Tumors and Endocrine Cell Micronests Resected by Both Endoscopic Treatments and Surgery |
| title_full_unstemmed | A Case of Fifteen Simultaneous Rectal Neuroendocrine Tumors and Endocrine Cell Micronests Resected by Both Endoscopic Treatments and Surgery |
| title_short | A Case of Fifteen Simultaneous Rectal Neuroendocrine Tumors and Endocrine Cell Micronests Resected by Both Endoscopic Treatments and Surgery |
| title_sort | case of fifteen simultaneous rectal neuroendocrine tumors and endocrine cell micronests resected by both endoscopic treatments and surgery |
| topic | rectal neuroendocrine tumor endoscopic submucosal dissection endocrine cell micronests |
| url | https://www.karger.com/Article/FullText/521522 |
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