Osteoclast-like stromal giant cells in breast cancer likely belong to the spectrum of immunosuppressive tumor-associated macrophages

Osteoclast-like stromal giant cells in breast cancer likely belong to the spectrum of immunosuppressive tumor-associated macrophages

Background: Breast cancer with osteoclast-like stromal giant cells (OSGC) is an exceedingly rare morphological pattern of invasive breast carcinoma. The tumor immune microenvironment (TIME) of these tumors is populated by OSGC, which resemble osteoclasts and show a histiocytic-like immunophenotype....

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Bibliographic Details
Main Authors: Elham Sajjadi, Gabriella Gaudioso, Andrea Terrasi, Francesca Boggio, Konstantinos Venetis, Mariia Ivanova, Letizia Bertolasi, Gianluca Lopez, Letterio Runza, Alice Premoli, Daniele Lorenzini, Elena Guerini-Rocco, Stefano Ferrero, Valentina Vaira, Nicola Fusco
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Molecular Biosciences
Subjects:
breast cancer
osteoclast-like giant cells (OGCs)
osteoclast-like stromal giant cells
tumor microenevironment
tumor immune microenvironment
tumor-infiltrating lymphocytes (TILs)
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.894247/full

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