Rational Design and Fabrication of Biomimetic Hierarchical Scaffolds With Bone-Matchable Strength for Bone Regeneration
The development of scaffolds with bone-mimicking compositions, hierarchical structure, and bone-matchable mechanical properties may offer a novel route for the achievement of effective bone regeneration. Although bioactive glasses have been widely utilized for bone regeneration at the clinical level...
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| Language: | English |
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Frontiers Media S.A.
2021-02-01
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| Series: | Frontiers in Materials |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmats.2020.622669/full |
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| author | Ruixian Lian Peng Xie Lan Xiao Lan Xiao Zoya Iqbal Shihao Zhang Joachim Kohn Xue Qu Changsheng Liu Yulin Li |
| author_facet | Ruixian Lian Peng Xie Lan Xiao Lan Xiao Zoya Iqbal Shihao Zhang Joachim Kohn Xue Qu Changsheng Liu Yulin Li |
| author_sort | Ruixian Lian |
| collection | DOAJ |
| description | The development of scaffolds with bone-mimicking compositions, hierarchical structure, and bone-matchable mechanical properties may offer a novel route for the achievement of effective bone regeneration. Although bioactive glasses have been widely utilized for bone regeneration at the clinical level, their brittleness and uncontrolled pore structure limit further applications. Herein, this study aims to develop a kind of bioactive scaffold with a macroporous/microporous/mesoporous structure via impregnating a sponge template with mesoporous bioactive glass (MBG) sol, followed by sponge template removal. In order to improve the mechanical properties and stability of the MBG scaffolds, desaminotyrosyl ethyl tyrosine polycarbonates (PDTEC), a biodegradable polymer which does not induce acid side-effects caused by conventional polylactide, was selected to decorate the resulting hierarchical scaffolds through a surface coating approach. The PDTEC functionalization endowed the scaffolds with improved mechanical strength matching the bearable range of trabecular bone (2–12 MPa). Meanwhile, the relative neutral pH value was maintained during their degradation process. In vitro studies demonstrated that the PDTEC accelerated the biomineralization of the scaffolds, and promoted the attachment and proliferation, holding high promise for bone regeneration. |
| first_indexed | 2024-12-14T06:51:03Z |
| format | Article |
| id | doaj.art-e7b26e23ff0740c6b49e7fc6e28ce218 |
| institution | Directory Open Access Journal |
| issn | 2296-8016 |
| language | English |
| last_indexed | 2024-12-14T06:51:03Z |
| publishDate | 2021-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Materials |
| spelling | doaj.art-e7b26e23ff0740c6b49e7fc6e28ce2182022-12-21T23:12:54ZengFrontiers Media S.A.Frontiers in Materials2296-80162021-02-01710.3389/fmats.2020.622669622669Rational Design and Fabrication of Biomimetic Hierarchical Scaffolds With Bone-Matchable Strength for Bone RegenerationRuixian Lian0Peng Xie1Lan Xiao2Lan Xiao3Zoya Iqbal4Shihao Zhang5Joachim Kohn6Xue Qu7Changsheng Liu8Yulin Li9The State Key Laboratory of Bioreactor Engineering and Key Laboratory for Ultrafine Materials of Ministry of Education, Key Laboratory for Ultrafine Materials of Ministry of Education, Engineering Research Centre for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai, ChinaThe State Key Laboratory of Bioreactor Engineering and Key Laboratory for Ultrafine Materials of Ministry of Education, Key Laboratory for Ultrafine Materials of Ministry of Education, Engineering Research Centre for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai, ChinaInstitute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, AustraliaThe Australia-China Centre for Tissue Engineering and Regenerative Medicine (ACCTERM), Brisbane, QLD, AustraliaThe State Key Laboratory of Bioreactor Engineering and Key Laboratory for Ultrafine Materials of Ministry of Education, Key Laboratory for Ultrafine Materials of Ministry of Education, Engineering Research Centre for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai, ChinaNew Organic Chemical Materials Hubei Collaborative Innovation Center, Key Laboratory of Organic Functional Molecular Synthesis and Application of Ministry of Education, College of Chemistry and Chemical Engineering, Hubei University, Wuhan, ChinaDepartment of Chemistry and Chemical Biology, New Jersey Center for Biomaterials, Piscataway, NJ, United StatesThe State Key Laboratory of Bioreactor Engineering and Key Laboratory for Ultrafine Materials of Ministry of Education, Key Laboratory for Ultrafine Materials of Ministry of Education, Engineering Research Centre for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai, ChinaThe State Key Laboratory of Bioreactor Engineering and Key Laboratory for Ultrafine Materials of Ministry of Education, Key Laboratory for Ultrafine Materials of Ministry of Education, Engineering Research Centre for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai, ChinaThe State Key Laboratory of Bioreactor Engineering and Key Laboratory for Ultrafine Materials of Ministry of Education, Key Laboratory for Ultrafine Materials of Ministry of Education, Engineering Research Centre for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai, ChinaThe development of scaffolds with bone-mimicking compositions, hierarchical structure, and bone-matchable mechanical properties may offer a novel route for the achievement of effective bone regeneration. Although bioactive glasses have been widely utilized for bone regeneration at the clinical level, their brittleness and uncontrolled pore structure limit further applications. Herein, this study aims to develop a kind of bioactive scaffold with a macroporous/microporous/mesoporous structure via impregnating a sponge template with mesoporous bioactive glass (MBG) sol, followed by sponge template removal. In order to improve the mechanical properties and stability of the MBG scaffolds, desaminotyrosyl ethyl tyrosine polycarbonates (PDTEC), a biodegradable polymer which does not induce acid side-effects caused by conventional polylactide, was selected to decorate the resulting hierarchical scaffolds through a surface coating approach. The PDTEC functionalization endowed the scaffolds with improved mechanical strength matching the bearable range of trabecular bone (2–12 MPa). Meanwhile, the relative neutral pH value was maintained during their degradation process. In vitro studies demonstrated that the PDTEC accelerated the biomineralization of the scaffolds, and promoted the attachment and proliferation, holding high promise for bone regeneration.https://www.frontiersin.org/articles/10.3389/fmats.2020.622669/fullbioactive glasspolymer coatingsol–gel methodbone mimicking hierarchical scaffoldsbiomineralizationbone regeneration |
| spellingShingle | Ruixian Lian Peng Xie Lan Xiao Lan Xiao Zoya Iqbal Shihao Zhang Joachim Kohn Xue Qu Changsheng Liu Yulin Li Rational Design and Fabrication of Biomimetic Hierarchical Scaffolds With Bone-Matchable Strength for Bone Regeneration Frontiers in Materials bioactive glass polymer coating sol–gel method bone mimicking hierarchical scaffolds biomineralization bone regeneration |
| title | Rational Design and Fabrication of Biomimetic Hierarchical Scaffolds With Bone-Matchable Strength for Bone Regeneration |
| title_full | Rational Design and Fabrication of Biomimetic Hierarchical Scaffolds With Bone-Matchable Strength for Bone Regeneration |
| title_fullStr | Rational Design and Fabrication of Biomimetic Hierarchical Scaffolds With Bone-Matchable Strength for Bone Regeneration |
| title_full_unstemmed | Rational Design and Fabrication of Biomimetic Hierarchical Scaffolds With Bone-Matchable Strength for Bone Regeneration |
| title_short | Rational Design and Fabrication of Biomimetic Hierarchical Scaffolds With Bone-Matchable Strength for Bone Regeneration |
| title_sort | rational design and fabrication of biomimetic hierarchical scaffolds with bone matchable strength for bone regeneration |
| topic | bioactive glass polymer coating sol–gel method bone mimicking hierarchical scaffolds biomineralization bone regeneration |
| url | https://www.frontiersin.org/articles/10.3389/fmats.2020.622669/full |
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