The Finite Element Analysis Research on Microneedle Design Strategy and Transdermal Drug Delivery System
Microneedles (MNs) as a novel transdermal drug delivery system have shown great potential for therapeutic and disease diagnosis applications by continually providing minimally invasive, portable, cost-effective, high bioavailability, and easy-to-use tools compared to traditional parenteral administr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/8/1625 |
| _version_ | 1827617677243318272 |
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| author | Qinying Yan Shulin Shen Yan Wang Jiaqi Weng Aiqun Wan Gensheng Yang Lili Feng |
| author_facet | Qinying Yan Shulin Shen Yan Wang Jiaqi Weng Aiqun Wan Gensheng Yang Lili Feng |
| author_sort | Qinying Yan |
| collection | DOAJ |
| description | Microneedles (MNs) as a novel transdermal drug delivery system have shown great potential for therapeutic and disease diagnosis applications by continually providing minimally invasive, portable, cost-effective, high bioavailability, and easy-to-use tools compared to traditional parenteral administrations. However, microneedle transdermal drug delivery is still in its infancy. Many research studies need further in-depth exploration, such as safety, structural characteristics, and drug loading performance evaluation. Finite element analysis (FEA) uses mathematical approximations to simulate real physical systems (geometry and load conditions). It can simplify complex engineering problems to guide the precise preparation and potential industrialization of microneedles, which has attracted extensive attention. This article introduces FEA research for microneedle transdermal drug delivery systems, focusing on microneedle design strategy, skin mechanics models, skin permeability, and the FEA research on drug delivery by MNs. |
| first_indexed | 2024-03-09T09:51:23Z |
| format | Article |
| id | doaj.art-e7b4412ebb1d4bd29fcdc73a9bab5476 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T09:51:23Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-e7b4412ebb1d4bd29fcdc73a9bab54762023-12-02T00:09:45ZengMDPI AGPharmaceutics1999-49232022-08-01148162510.3390/pharmaceutics14081625The Finite Element Analysis Research on Microneedle Design Strategy and Transdermal Drug Delivery SystemQinying Yan0Shulin Shen1Yan Wang2Jiaqi Weng3Aiqun Wan4Gensheng Yang5Lili Feng6College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, ChinaCollege of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, ChinaCollege of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, ChinaCollege of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, ChinaCollege of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, ChinaCollege of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, ChinaDepartment of Ophthalmology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, ChinaMicroneedles (MNs) as a novel transdermal drug delivery system have shown great potential for therapeutic and disease diagnosis applications by continually providing minimally invasive, portable, cost-effective, high bioavailability, and easy-to-use tools compared to traditional parenteral administrations. However, microneedle transdermal drug delivery is still in its infancy. Many research studies need further in-depth exploration, such as safety, structural characteristics, and drug loading performance evaluation. Finite element analysis (FEA) uses mathematical approximations to simulate real physical systems (geometry and load conditions). It can simplify complex engineering problems to guide the precise preparation and potential industrialization of microneedles, which has attracted extensive attention. This article introduces FEA research for microneedle transdermal drug delivery systems, focusing on microneedle design strategy, skin mechanics models, skin permeability, and the FEA research on drug delivery by MNs.https://www.mdpi.com/1999-4923/14/8/1625microneedletransdermalpersonalized drug deliveryfinite element analysisoptimization |
| spellingShingle | Qinying Yan Shulin Shen Yan Wang Jiaqi Weng Aiqun Wan Gensheng Yang Lili Feng The Finite Element Analysis Research on Microneedle Design Strategy and Transdermal Drug Delivery System Pharmaceutics microneedle transdermal personalized drug delivery finite element analysis optimization |
| title | The Finite Element Analysis Research on Microneedle Design Strategy and Transdermal Drug Delivery System |
| title_full | The Finite Element Analysis Research on Microneedle Design Strategy and Transdermal Drug Delivery System |
| title_fullStr | The Finite Element Analysis Research on Microneedle Design Strategy and Transdermal Drug Delivery System |
| title_full_unstemmed | The Finite Element Analysis Research on Microneedle Design Strategy and Transdermal Drug Delivery System |
| title_short | The Finite Element Analysis Research on Microneedle Design Strategy and Transdermal Drug Delivery System |
| title_sort | finite element analysis research on microneedle design strategy and transdermal drug delivery system |
| topic | microneedle transdermal personalized drug delivery finite element analysis optimization |
| url | https://www.mdpi.com/1999-4923/14/8/1625 |
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