ION CHANNEL TRPA1 IS A PROMISING THERAPEUTIC TARGET FOR TREATMENT OF PAIN
TRPA1 is an ankyrin receptor of TRP family. It is a non-selective, calcium-permeable cation channel that is highly expressed by a subset of small diameter sensory neurons with cell bodies in the dorsal root, trigeminal, nodose and jugular ganglia. In the last time information about the role of TRPA1...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Belgorod National Research University
2015-12-01
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| Series: | Research Results in Pharmacology |
| Subjects: | |
| Online Access: | https://rrpharmacology.pensoft.net/article/31022/download/pdf/ |
| _version_ | 1797427606348365824 |
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| author | Evgeniya Beskhmelnitsyna Mikhail Korokin Tatyana Avtina Olga Martynova Ivan Varavin Anton Tishin |
| author_facet | Evgeniya Beskhmelnitsyna Mikhail Korokin Tatyana Avtina Olga Martynova Ivan Varavin Anton Tishin |
| author_sort | Evgeniya Beskhmelnitsyna |
| collection | DOAJ |
| description | TRPA1 is an ankyrin receptor of TRP family. It is a non-selective, calcium-permeable cation channel that is highly expressed by a subset of small diameter sensory neurons with cell bodies in the dorsal root, trigeminal, nodose and jugular ganglia. In the last time information about the role of TRPA1 in pain and cold sensitivity, as well as in the formation and maintenance of inflammation is increasing in scientific literature. Given this information, the interest for search and study of pharmacological agents, which selectively blocked of TRPA1 and reduced the severity of pain and inflammation is increasing. |
| first_indexed | 2024-03-09T08:47:00Z |
| format | Article |
| id | doaj.art-e7b4cfbfeb0a42308ce35307f6e9433f |
| institution | Directory Open Access Journal |
| issn | 2658-381X |
| language | English |
| last_indexed | 2024-03-09T08:47:00Z |
| publishDate | 2015-12-01 |
| publisher | Belgorod National Research University |
| record_format | Article |
| series | Research Results in Pharmacology |
| spelling | doaj.art-e7b4cfbfeb0a42308ce35307f6e9433f2023-12-02T15:12:33ZengBelgorod National Research UniversityResearch Results in Pharmacology2658-381X2015-12-0111202210.18413/2500-235X-2015-1-4-21-2431022ION CHANNEL TRPA1 IS A PROMISING THERAPEUTIC TARGET FOR TREATMENT OF PAINEvgeniya BeskhmelnitsynaMikhail KorokinTatyana AvtinaOlga MartynovaIvan VaravinAnton TishinTRPA1 is an ankyrin receptor of TRP family. It is a non-selective, calcium-permeable cation channel that is highly expressed by a subset of small diameter sensory neurons with cell bodies in the dorsal root, trigeminal, nodose and jugular ganglia. In the last time information about the role of TRPA1 in pain and cold sensitivity, as well as in the formation and maintenance of inflammation is increasing in scientific literature. Given this information, the interest for search and study of pharmacological agents, which selectively blocked of TRPA1 and reduced the severity of pain and inflammation is increasing.https://rrpharmacology.pensoft.net/article/31022/download/pdf/ion channel TRP; TRPA1; pain; ketorolaknocicepti |
| spellingShingle | Evgeniya Beskhmelnitsyna Mikhail Korokin Tatyana Avtina Olga Martynova Ivan Varavin Anton Tishin ION CHANNEL TRPA1 IS A PROMISING THERAPEUTIC TARGET FOR TREATMENT OF PAIN Research Results in Pharmacology ion channel TRP; TRPA1; pain; ketorolak nocicepti |
| title | ION CHANNEL TRPA1 IS A PROMISING THERAPEUTIC TARGET FOR TREATMENT OF PAIN |
| title_full | ION CHANNEL TRPA1 IS A PROMISING THERAPEUTIC TARGET FOR TREATMENT OF PAIN |
| title_fullStr | ION CHANNEL TRPA1 IS A PROMISING THERAPEUTIC TARGET FOR TREATMENT OF PAIN |
| title_full_unstemmed | ION CHANNEL TRPA1 IS A PROMISING THERAPEUTIC TARGET FOR TREATMENT OF PAIN |
| title_short | ION CHANNEL TRPA1 IS A PROMISING THERAPEUTIC TARGET FOR TREATMENT OF PAIN |
| title_sort | ion channel trpa1 is a promising therapeutic target for treatment of pain |
| topic | ion channel TRP; TRPA1; pain; ketorolak nocicepti |
| url | https://rrpharmacology.pensoft.net/article/31022/download/pdf/ |
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