An Implantable Magneto-Responsive Poly(aspartamide) Based Electrospun Scaffold for Hyperthermia Treatment
When exposed to an alternating magnetic field, superparamagnetic nanoparticles can elicit the required hyperthermic effect while also being excellent magnetic resonance imaging (MRI) contrast agents. Their main drawback is that they diffuse out of the area of interest in one or two days, thus preven...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/12/9/1476 |
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| author | Tamás Veres Constantinos Voniatis Kristóf Molnár Dániel Nesztor Daniella Fehér Andrea Ferencz Iván Gresits György Thuróczy Bence Gábor Márkus Ferenc Simon Norbert Marcell Nemes Mar García-Hernández Lilla Reiniger Ildikó Horváth Domokos Máthé Krisztián Szigeti Etelka Tombácz Angela Jedlovszky-Hajdu |
| author_facet | Tamás Veres Constantinos Voniatis Kristóf Molnár Dániel Nesztor Daniella Fehér Andrea Ferencz Iván Gresits György Thuróczy Bence Gábor Márkus Ferenc Simon Norbert Marcell Nemes Mar García-Hernández Lilla Reiniger Ildikó Horváth Domokos Máthé Krisztián Szigeti Etelka Tombácz Angela Jedlovszky-Hajdu |
| author_sort | Tamás Veres |
| collection | DOAJ |
| description | When exposed to an alternating magnetic field, superparamagnetic nanoparticles can elicit the required hyperthermic effect while also being excellent magnetic resonance imaging (MRI) contrast agents. Their main drawback is that they diffuse out of the area of interest in one or two days, thus preventing a continuous application during the typical several-cycle multi-week treatment. To solve this issue, our aim was to synthesise an implantable, biodegradable membrane infused with magnetite that enabled long-term treatment while having adequate MRI contrast and hyperthermic capabilities. To immobilise the nanoparticles inside the scaffold, they were synthesised inside hydrogel fibres. First, polysuccinimide (PSI) fibres were produced by electrospinning and crosslinked, and then, magnetitc iron oxide nanoparticles (MIONs) were synthesised inside and in-between the fibres of the hydrogel membranes with the well-known co-precipitation method. The attenuated total reflectance Fourier-transform infrared spectroscopy (ATR-FTIR) investigation proved the success of the chemical synthesis and the presence of iron oxide, and the superconducting quantum interference device (SQUID) study revealed their superparamagnetic property. The magnetic hyperthermia efficiency of the samples was significant. The given alternating current (AC) magnetic field could induce a temperature rise of 5 °C (from 37 °C to 42 °C) in less than 2 min even for five quick heat-cool cycles or for five consecutive days without considerable heat generation loss in the samples. Short-term (1 day and 7 day) biocompatibility, biodegradability and MRI contrast capability were investigated in vivo on Wistar rats. The results showed excellent MRI contrast and minimal acute inflammation. |
| first_indexed | 2024-03-10T03:52:09Z |
| format | Article |
| id | doaj.art-e7b63287d8734a2083666b7822c4b199 |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-10T03:52:09Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-e7b63287d8734a2083666b7822c4b1992023-11-23T08:54:47ZengMDPI AGNanomaterials2079-49912022-04-01129147610.3390/nano12091476An Implantable Magneto-Responsive Poly(aspartamide) Based Electrospun Scaffold for Hyperthermia TreatmentTamás Veres0Constantinos Voniatis1Kristóf Molnár2Dániel Nesztor3Daniella Fehér4Andrea Ferencz5Iván Gresits6György Thuróczy7Bence Gábor Márkus8Ferenc Simon9Norbert Marcell Nemes10Mar García-Hernández11Lilla Reiniger12Ildikó Horváth13Domokos Máthé14Krisztián Szigeti15Etelka Tombácz16Angela Jedlovszky-Hajdu17Laboratory of Nanochemistry, Department of Biophysics and Radiation Biology, Semmelweis University, 1089 Budapest, HungaryLaboratory of Nanochemistry, Department of Biophysics and Radiation Biology, Semmelweis University, 1089 Budapest, HungaryLaboratory of Nanochemistry, Department of Biophysics and Radiation Biology, Semmelweis University, 1089 Budapest, HungaryDepartment of Food Engineering, University of Szeged, 6725 Szeged, HungaryHeart and Vascular Centre, Department of Surgical Research and Techniques, Semmelweis University, 1122 Budapest, HungaryHeart and Vascular Centre, Department of Surgical Research and Techniques, Semmelweis University, 1122 Budapest, HungaryDepartment of Biophysics and Radiation Biology, Semmelweis University, 1094 Budapest, HungaryNRIRR “Frédéric Joliot-Curie” National Research Institute for Radiobiology and Radiohygiene, 1221 Budapest, HungaryStavropoulos Center for Complex Quantum Matter, Department of Physics and Astronomy, University of Notre Dame, Notre Dame, IN 46556, USAInstitute of Physics, Budapest University of Technology and Economics, 1521 Budapest, HungaryGrupo de Física de Materiales Complejos (GFMC), Departamento de Física de Materiales, Universidad Complutense de Madrid, 28040 Madrid, SpainGrupo de Física de Materiales Complejos (GFMC), Departamento de Física de Materiales, Universidad Complutense de Madrid, 28040 Madrid, SpainDepartment of Pathology and Experimental Cancer Research, Semmelweis University, 1085 Budapest, HungaryDepartment of Biophysics and Radiation Biology, Semmelweis University, 1094 Budapest, HungaryDepartment of Biophysics and Radiation Biology, Semmelweis University, 1094 Budapest, HungaryDepartment of Biophysics and Radiation Biology, Semmelweis University, 1094 Budapest, HungaryDepartment of Food Engineering, University of Szeged, 6725 Szeged, HungaryLaboratory of Nanochemistry, Department of Biophysics and Radiation Biology, Semmelweis University, 1089 Budapest, HungaryWhen exposed to an alternating magnetic field, superparamagnetic nanoparticles can elicit the required hyperthermic effect while also being excellent magnetic resonance imaging (MRI) contrast agents. Their main drawback is that they diffuse out of the area of interest in one or two days, thus preventing a continuous application during the typical several-cycle multi-week treatment. To solve this issue, our aim was to synthesise an implantable, biodegradable membrane infused with magnetite that enabled long-term treatment while having adequate MRI contrast and hyperthermic capabilities. To immobilise the nanoparticles inside the scaffold, they were synthesised inside hydrogel fibres. First, polysuccinimide (PSI) fibres were produced by electrospinning and crosslinked, and then, magnetitc iron oxide nanoparticles (MIONs) were synthesised inside and in-between the fibres of the hydrogel membranes with the well-known co-precipitation method. The attenuated total reflectance Fourier-transform infrared spectroscopy (ATR-FTIR) investigation proved the success of the chemical synthesis and the presence of iron oxide, and the superconducting quantum interference device (SQUID) study revealed their superparamagnetic property. The magnetic hyperthermia efficiency of the samples was significant. The given alternating current (AC) magnetic field could induce a temperature rise of 5 °C (from 37 °C to 42 °C) in less than 2 min even for five quick heat-cool cycles or for five consecutive days without considerable heat generation loss in the samples. Short-term (1 day and 7 day) biocompatibility, biodegradability and MRI contrast capability were investigated in vivo on Wistar rats. The results showed excellent MRI contrast and minimal acute inflammation.https://www.mdpi.com/2079-4991/12/9/1476theranosticsmagnetic iron oxide nanoparticlespolysuccinimideelectrospinninghyperthermiaMRI |
| spellingShingle | Tamás Veres Constantinos Voniatis Kristóf Molnár Dániel Nesztor Daniella Fehér Andrea Ferencz Iván Gresits György Thuróczy Bence Gábor Márkus Ferenc Simon Norbert Marcell Nemes Mar García-Hernández Lilla Reiniger Ildikó Horváth Domokos Máthé Krisztián Szigeti Etelka Tombácz Angela Jedlovszky-Hajdu An Implantable Magneto-Responsive Poly(aspartamide) Based Electrospun Scaffold for Hyperthermia Treatment Nanomaterials theranostics magnetic iron oxide nanoparticles polysuccinimide electrospinning hyperthermia MRI |
| title | An Implantable Magneto-Responsive Poly(aspartamide) Based Electrospun Scaffold for Hyperthermia Treatment |
| title_full | An Implantable Magneto-Responsive Poly(aspartamide) Based Electrospun Scaffold for Hyperthermia Treatment |
| title_fullStr | An Implantable Magneto-Responsive Poly(aspartamide) Based Electrospun Scaffold for Hyperthermia Treatment |
| title_full_unstemmed | An Implantable Magneto-Responsive Poly(aspartamide) Based Electrospun Scaffold for Hyperthermia Treatment |
| title_short | An Implantable Magneto-Responsive Poly(aspartamide) Based Electrospun Scaffold for Hyperthermia Treatment |
| title_sort | implantable magneto responsive poly aspartamide based electrospun scaffold for hyperthermia treatment |
| topic | theranostics magnetic iron oxide nanoparticles polysuccinimide electrospinning hyperthermia MRI |
| url | https://www.mdpi.com/2079-4991/12/9/1476 |
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