Lipoprotein Subclasses Independently Contribute to Subclinical Variance of Microvascular and Macrovascular Health
Lipoproteins are important cardiovascular (CV) risk biomarkers. This study aimed to investigate the associations of lipoprotein subclasses with micro- and macrovascular biomarkers to better understand how these subclasses relate to atherosclerotic CV diseases. One hundred and fifty-eight serum sampl...
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| Format: | Article |
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MDPI AG
2022-07-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/15/4760 |
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| author | Lukas Streese Hansjörg Habisch Arne Deiseroth Justin Carrard Denis Infanger Arno Schmidt-Trucksäss Tobias Madl Henner Hanssen |
| author_facet | Lukas Streese Hansjörg Habisch Arne Deiseroth Justin Carrard Denis Infanger Arno Schmidt-Trucksäss Tobias Madl Henner Hanssen |
| author_sort | Lukas Streese |
| collection | DOAJ |
| description | Lipoproteins are important cardiovascular (CV) risk biomarkers. This study aimed to investigate the associations of lipoprotein subclasses with micro- and macrovascular biomarkers to better understand how these subclasses relate to atherosclerotic CV diseases. One hundred and fifty-eight serum samples from the EXAMIN AGE study, consisting of healthy individuals and CV risk patients, were analysed with nuclear magnetic resonance (NMR) spectroscopy to quantify lipoprotein subclasses. Microvascular health was quantified by measuring retinal arteriolar and venular diameters. Macrovascular health was quantified by measuring carotid-to-femoral pulse wave velocity (PWV). Nineteen lipoprotein subclasses showed statistically significant associations with retinal vessel diameters and nine with PWV. These lipoprotein subclasses together explained up to 26% of variation (R<sup>2</sup> = 0.26, F(29,121) = 2.80, <i>p</i> < 0.001) in micro- and 12% (R<sup>2</sup> = 0.12, F(29,124) = 1.70, <i>p</i> = 0.025) of variation in macrovascular health. High-density (HDL-C) and low-density lipoprotein cholesterol (LDL-C) as well as triglycerides together explained up to 13% (R<sup>2</sup> = 0.13, F(3143) = 8.42, <i>p</i> < 0.001) of micro- and 8% (R<sup>2</sup> = 0.08, F(3145) = 5.46, <i>p</i> = 0.001) of macrovascular variation. Lipoprotein subclasses seem to reflect micro- and macrovascular end organ damage more precisely as compared to only measuring HDL-C, LDL-C and triglycerides. Further studies are needed to analyse how the additional quantification of lipoprotein subclasses can improve CV risk stratification and CV disease prediction. |
| first_indexed | 2024-03-09T12:22:17Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T12:22:17Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-e7b66b1a72fe4502953f671f3e7578d32023-11-30T22:39:50ZengMDPI AGMolecules1420-30492022-07-012715476010.3390/molecules27154760Lipoprotein Subclasses Independently Contribute to Subclinical Variance of Microvascular and Macrovascular HealthLukas Streese0Hansjörg Habisch1Arne Deiseroth2Justin Carrard3Denis Infanger4Arno Schmidt-Trucksäss5Tobias Madl6Henner Hanssen7Department of Sport, Exercise and Health, Medical Faculty, University of Basel, 4052 Basel, SwitzerlandGottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Molecular Biology and Biochemistry, Medical University of Graz, 8010 Graz, AustriaDepartment of Sport, Exercise and Health, Medical Faculty, University of Basel, 4052 Basel, SwitzerlandDepartment of Sport, Exercise and Health, Medical Faculty, University of Basel, 4052 Basel, SwitzerlandDepartment of Sport, Exercise and Health, Medical Faculty, University of Basel, 4052 Basel, SwitzerlandDepartment of Sport, Exercise and Health, Medical Faculty, University of Basel, 4052 Basel, SwitzerlandGottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Molecular Biology and Biochemistry, Medical University of Graz, 8010 Graz, AustriaDepartment of Sport, Exercise and Health, Medical Faculty, University of Basel, 4052 Basel, SwitzerlandLipoproteins are important cardiovascular (CV) risk biomarkers. This study aimed to investigate the associations of lipoprotein subclasses with micro- and macrovascular biomarkers to better understand how these subclasses relate to atherosclerotic CV diseases. One hundred and fifty-eight serum samples from the EXAMIN AGE study, consisting of healthy individuals and CV risk patients, were analysed with nuclear magnetic resonance (NMR) spectroscopy to quantify lipoprotein subclasses. Microvascular health was quantified by measuring retinal arteriolar and venular diameters. Macrovascular health was quantified by measuring carotid-to-femoral pulse wave velocity (PWV). Nineteen lipoprotein subclasses showed statistically significant associations with retinal vessel diameters and nine with PWV. These lipoprotein subclasses together explained up to 26% of variation (R<sup>2</sup> = 0.26, F(29,121) = 2.80, <i>p</i> < 0.001) in micro- and 12% (R<sup>2</sup> = 0.12, F(29,124) = 1.70, <i>p</i> = 0.025) of variation in macrovascular health. High-density (HDL-C) and low-density lipoprotein cholesterol (LDL-C) as well as triglycerides together explained up to 13% (R<sup>2</sup> = 0.13, F(3143) = 8.42, <i>p</i> < 0.001) of micro- and 8% (R<sup>2</sup> = 0.08, F(3145) = 5.46, <i>p</i> = 0.001) of macrovascular variation. Lipoprotein subclasses seem to reflect micro- and macrovascular end organ damage more precisely as compared to only measuring HDL-C, LDL-C and triglycerides. Further studies are needed to analyse how the additional quantification of lipoprotein subclasses can improve CV risk stratification and CV disease prediction.https://www.mdpi.com/1420-3049/27/15/4760cardiovascular risklipidsNMR spectroscopypulse wave velocityretinal vessel diameters |
| spellingShingle | Lukas Streese Hansjörg Habisch Arne Deiseroth Justin Carrard Denis Infanger Arno Schmidt-Trucksäss Tobias Madl Henner Hanssen Lipoprotein Subclasses Independently Contribute to Subclinical Variance of Microvascular and Macrovascular Health Molecules cardiovascular risk lipids NMR spectroscopy pulse wave velocity retinal vessel diameters |
| title | Lipoprotein Subclasses Independently Contribute to Subclinical Variance of Microvascular and Macrovascular Health |
| title_full | Lipoprotein Subclasses Independently Contribute to Subclinical Variance of Microvascular and Macrovascular Health |
| title_fullStr | Lipoprotein Subclasses Independently Contribute to Subclinical Variance of Microvascular and Macrovascular Health |
| title_full_unstemmed | Lipoprotein Subclasses Independently Contribute to Subclinical Variance of Microvascular and Macrovascular Health |
| title_short | Lipoprotein Subclasses Independently Contribute to Subclinical Variance of Microvascular and Macrovascular Health |
| title_sort | lipoprotein subclasses independently contribute to subclinical variance of microvascular and macrovascular health |
| topic | cardiovascular risk lipids NMR spectroscopy pulse wave velocity retinal vessel diameters |
| url | https://www.mdpi.com/1420-3049/27/15/4760 |
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