The Role of Bovine Kappa-Casein Glycomacropeptide in Modulating the Microbiome and Inflammatory Responses of Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) is a common gastrointestinal disorder marked by chronic abdominal pain, bloating, and irregular bowel habits. Effective treatments are still actively sought. Kappa-casein glycomacropeptide (GMP), a milk-derived peptide, holds promise because it can modulate the gut mic...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/18/3991 |
| _version_ | 1797578288560865280 |
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| author | Yunyao Qu Si Hong Park David C. Dallas |
| author_facet | Yunyao Qu Si Hong Park David C. Dallas |
| author_sort | Yunyao Qu |
| collection | DOAJ |
| description | Irritable bowel syndrome (IBS) is a common gastrointestinal disorder marked by chronic abdominal pain, bloating, and irregular bowel habits. Effective treatments are still actively sought. Kappa-casein glycomacropeptide (GMP), a milk-derived peptide, holds promise because it can modulate the gut microbiome, immune responses, gut motility, and barrier functions, as well as binding toxins. These properties align with the recognized pathophysiological aspects of IBS, including gut microbiota imbalances, immune system dysregulation, and altered gut barrier functions. This review delves into GMP’s role in regulating the gut microbiome, accentuating its influence on bacterial populations and its potential to promote beneficial bacteria while inhibiting pathogenic varieties. It further investigates the gut microbial shifts observed in IBS patients and contemplates GMP’s potential for restoring microbial equilibrium and overall gut health. The anti-inflammatory attributes of GMP, especially its impact on vital inflammatory markers and capacity to temper the low-grade inflammation present in IBS are also discussed. In addition, this review delves into current research on GMP’s effects on gut motility and barrier integrity and examines the changes in gut motility and barrier function observed in IBS sufferers. The overarching goal is to assess the potential clinical utility of GMP in IBS management. |
| first_indexed | 2024-03-10T22:20:48Z |
| format | Article |
| id | doaj.art-e7b882df1db24ddbb0949d3ae566d4bf |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T22:20:48Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-e7b882df1db24ddbb0949d3ae566d4bf2023-11-19T12:18:47ZengMDPI AGNutrients2072-66432023-09-011518399110.3390/nu15183991The Role of Bovine Kappa-Casein Glycomacropeptide in Modulating the Microbiome and Inflammatory Responses of Irritable Bowel SyndromeYunyao Qu0Si Hong Park1David C. Dallas2Department of Food Science & Technology, Oregon State University, Corvallis, OR 97331, USADepartment of Food Science & Technology, Oregon State University, Corvallis, OR 97331, USADepartment of Food Science & Technology, Oregon State University, Corvallis, OR 97331, USAIrritable bowel syndrome (IBS) is a common gastrointestinal disorder marked by chronic abdominal pain, bloating, and irregular bowel habits. Effective treatments are still actively sought. Kappa-casein glycomacropeptide (GMP), a milk-derived peptide, holds promise because it can modulate the gut microbiome, immune responses, gut motility, and barrier functions, as well as binding toxins. These properties align with the recognized pathophysiological aspects of IBS, including gut microbiota imbalances, immune system dysregulation, and altered gut barrier functions. This review delves into GMP’s role in regulating the gut microbiome, accentuating its influence on bacterial populations and its potential to promote beneficial bacteria while inhibiting pathogenic varieties. It further investigates the gut microbial shifts observed in IBS patients and contemplates GMP’s potential for restoring microbial equilibrium and overall gut health. The anti-inflammatory attributes of GMP, especially its impact on vital inflammatory markers and capacity to temper the low-grade inflammation present in IBS are also discussed. In addition, this review delves into current research on GMP’s effects on gut motility and barrier integrity and examines the changes in gut motility and barrier function observed in IBS sufferers. The overarching goal is to assess the potential clinical utility of GMP in IBS management.https://www.mdpi.com/2072-6643/15/18/3991irritable bowel syndrome (IBS)kappa-casein glycomacropeptide (GMP)gut microbiomegut motilitygut barrier functioninflammation |
| spellingShingle | Yunyao Qu Si Hong Park David C. Dallas The Role of Bovine Kappa-Casein Glycomacropeptide in Modulating the Microbiome and Inflammatory Responses of Irritable Bowel Syndrome Nutrients irritable bowel syndrome (IBS) kappa-casein glycomacropeptide (GMP) gut microbiome gut motility gut barrier function inflammation |
| title | The Role of Bovine Kappa-Casein Glycomacropeptide in Modulating the Microbiome and Inflammatory Responses of Irritable Bowel Syndrome |
| title_full | The Role of Bovine Kappa-Casein Glycomacropeptide in Modulating the Microbiome and Inflammatory Responses of Irritable Bowel Syndrome |
| title_fullStr | The Role of Bovine Kappa-Casein Glycomacropeptide in Modulating the Microbiome and Inflammatory Responses of Irritable Bowel Syndrome |
| title_full_unstemmed | The Role of Bovine Kappa-Casein Glycomacropeptide in Modulating the Microbiome and Inflammatory Responses of Irritable Bowel Syndrome |
| title_short | The Role of Bovine Kappa-Casein Glycomacropeptide in Modulating the Microbiome and Inflammatory Responses of Irritable Bowel Syndrome |
| title_sort | role of bovine kappa casein glycomacropeptide in modulating the microbiome and inflammatory responses of irritable bowel syndrome |
| topic | irritable bowel syndrome (IBS) kappa-casein glycomacropeptide (GMP) gut microbiome gut motility gut barrier function inflammation |
| url | https://www.mdpi.com/2072-6643/15/18/3991 |
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