Huntingtin CAG-expansion mutation results in a dominant negative effect

Huntingtin CAG-expansion mutation results in a dominant negative effect

Introduction: Huntington’s disease (HD) remains an incurable and fatal neurodegenerative disease long after CAG-expansion mutation in the huntingtin gene (HTT) was identified as the cause. The underlying pathological mechanism, whether HTT loss of function or gain of toxicity results from mutation,...

Полное описание

Библиографические подробности
Главные авторы: Tiago L. Laundos, Shu Li, Eric Cheang, Riccardo De Santis, Francesco M. Piccolo, Ali H. Brivanlou
Формат: Статья
Язык:English
Опубликовано: Frontiers Media S.A. 2023-09-01
Серии:Frontiers in Cell and Developmental Biology
Предметы:
Huntington’s disease (HD)
Huntingtin (HTT)
human embryonic stem cell (hESC)
dominant negative
organoids
Online-ссылка:https://www.frontiersin.org/articles/10.3389/fcell.2023.1252521/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2023.1252521/full

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