Huntingtin CAG-expansion mutation results in a dominant negative effect

Huntingtin CAG-expansion mutation results in a dominant negative effect

Introduction: Huntington’s disease (HD) remains an incurable and fatal neurodegenerative disease long after CAG-expansion mutation in the huntingtin gene (HTT) was identified as the cause. The underlying pathological mechanism, whether HTT loss of function or gain of toxicity results from mutation,...

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Bibliografiske detaljer
Main Authors:	Tiago L. Laundos, Shu Li, Eric Cheang, Riccardo De Santis, Francesco M. Piccolo, Ali H. Brivanlou
Format:	Article
Sprog:	English
Udgivet:	Frontiers Media S.A. 2023-09-01
Serier:	Frontiers in Cell and Developmental Biology
Fag:	Huntington’s disease (HD) Huntingtin (HTT) human embryonic stem cell (hESC) dominant negative organoids
Online adgang:	https://www.frontiersin.org/articles/10.3389/fcell.2023.1252521/full

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