BRCA1 or CDK12 loss sensitizes cells to CHK1 inhibitors

BRCA1 or CDK12 loss sensitizes cells to CHK1 inhibitors

A broad spectrum of tumors develop resistance to classic chemotherapy, necessitating the discovery of new therapies. One successful strategy exploits the synthetic lethality between poly(ADP-ribose) polymerase 1/2 proteins and DNA damage response genes, including BRCA1, a factor involved in homologo...

Full description

Bibliographic Details
Main Authors:	Hana Paculová, Juraj Kramara, Šárka Šimečková, Radek Fedr, Karel Souček, Ondřej Hylse, Kamil Paruch, Marek Svoboda, Martin Mistrík, Jiří Kohoutek
Format:	Article
Language:	English
Published:	IOS Press 2017-10-01
Series:	Tumor Biology
Online Access:	https://doi.org/10.1177/1010428317727479

Similar Items

The emerging roles of CDK12 in tumorigenesis
by: Hana Paculová, et al.
Published: (2017-10-01)

The CHK1 inhibitor MU380 significantly increases the sensitivity of human docetaxel‐resistant prostate cancer cells to gemcitabine through the induction of mitotic catastrophe
by: Stanislav Drápela, et al.
Published: (2020-10-01)

Cyclin K goes with Cdk12 and Cdk13
by: Kohoutek Jiri, et al.
Published: (2012-04-01)

3D Cell Culture Models Demonstrate a Role for FGF and WNT Signaling in Regulation of Lung Epithelial Cell Fate and Morphogenesis
by: Anas Rabata, et al.
Published: (2020-07-01)

Regulation of Chk1
by: Calonge Teresa M, et al.
Published: (2009-04-01)

Panobinostat enhances cytarabine and daunorubicin sensitivities in AML cells through suppressing the expression of BRCA1, CHK1, and Rad51.
by: Chengzhi Xie, et al.
Published: (2013-01-01)

Exploring the Synergy between PARP and CHK1 Inhibition in Matched <i>BRCA2</i> Mutant and Corrected Cells
by: Hannah L Smith, et al.
Published: (2020-04-01)

Ubiquitination of the DNA-damage checkpoint kinase CHK1 by TRAF4 is required for CHK1 activation
by: Xinfang Yu, et al.
Published: (2020-05-01)

BRD7 suppresses tumor chemosensitivity to CHK1 inhibitors by inhibiting USP1-mediated deubiquitination of CHK1
by: Lemin Li, et al.
Published: (2023-08-01)

Chk1 suppressed cell death
by: Meuth Mark
Published: (2010-09-01)

Combinations of ATR, Chk1 and Wee1 Inhibitors with Olaparib Are Active in Olaparib Resistant <i>Brca1</i> Proficient and Deficient Murine Ovarian Cells
by: Michela Chiappa, et al.
Published: (2022-04-01)

Synergistic targeting of BRCA1 mutated breast cancers with PARP and CDK2 inhibition
by: Diar Aziz, et al.
Published: (2021-08-01)

Sensitivity of cells to ATR and CHK1 inhibitors requires hyperactivation of CDK2 rather than endogenous replication stress or ATM dysfunction
by: Jennifer P. Ditano, et al.
Published: (2021-03-01)

Olaparib Combined with an ATR or Chk1 Inhibitor as a Treatment Strategy for Acquired Olaparib-Resistant <i>BRCA1</i> Mutant Ovarian Cells
by: Brian T. Burgess, et al.
Published: (2020-02-01)

Variability of fluorescence intensity distribution measured by flow cytometry is influenced by cell size and cell cycle progression
by: Radek Fedr, et al.
Published: (2023-03-01)

Interleukin 4 inducible 1 gene (IL4I1) is induced in chicken phagocytes by Salmonella Enteritidis infection
by: Marta Elsheimer-Matulova, et al.
Published: (2020-05-01)

Functions and inhibitors of CHK1 in cancer therapy
by: Kailong Jiang, et al.
Published: (2024-06-01)

A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint.
by: Marcel A T M van Vugt, et al.
Published: (2010-01-01)

A Mitotic Phosphorylation Feedback Network Connects Cdk1, Plk1, 53BP1, and Chk2 to Inactivate the G2/M DNA Damage Checkpoint
by: Yaffe, Michael B., et al.
Published: (2010)

Ring-Substituted 1-Hydroxynaphthalene-2-Carboxanilides Inhibit Proliferation and Trigger Mitochondria-Mediated Apoptosis
by: Tereza Kauerová, et al.
Published: (2020-05-01)

The CHK1 inhibitor prexasertib in BRCA wild-type platinum-resistant recurrent high-grade serous ovarian carcinoma: a phase 2 trial
by: Elena Giudice, et al.
Published: (2024-03-01)

Targeting the ATR-CHK1 Axis in Cancer Therapy
by: Stuart Rundle, et al.
Published: (2017-04-01)

Chk1 haploinsufficiency results in anemia and defective erythropoiesis.
by: Nathan C Boles, et al.
Published: (2010-01-01)

RASSF1A-LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2.
by: Pefani, D, et al.
Published: (2014)

CTP sensing and Mec1ATR-Rad53CHK1/CHK2 mediate a two-layered response to inhibition of glutamine metabolism.
by: Arta Ajazi, et al.
Published: (2022-03-01)

Analysis of the ATR-Chk1 and ATM-Chk2 pathways in male breast cancer revealed the prognostic significance of ATR expression
by: Anna Di Benedetto, et al.
Published: (2017-08-01)

Heterogeneity in conservation of multifunctional partner enzymes with meiotic importance, CDK2 kinase and BRCA1 ubiquitin ligase
by: Sergey Matveevsky, et al.
Published: (2021-09-01)

Phosphoglycerate Mutase Cooperates with Chk1 Kinase to Regulate Glycolysis
by: Takumi Mikawa, et al.
Published: (2020-07-01)

The Rad53CHK1/CHK2-Spt21NPAT and Tel1ATM axes couple glucose tolerance to histone dosage and subtelomeric silencing
by: Christopher Bruhn, et al.
Published: (2020-08-01)

Clinical Candidates Targeting the ATR–CHK1–WEE1 Axis in Cancer
by: Lukas Gorecki, et al.
Published: (2021-02-01)

Synergism Through WEE1 and CHK1 Inhibition in Acute Lymphoblastic Leukemia
by: Andrea Ghelli Luserna Di Rorà, et al.
Published: (2019-10-01)

CK1δ kinase activity is modulated by Chk1-mediated phosphorylation.
by: Joachim Bischof, et al.
Published: (2013-01-01)

Targeted inhibition of the ATR/CHK1 pathway overcomes resistance to olaparib and dysregulates DNA damage response protein expression in BRCA2 MUT ovarian cancer cells
by: Łukasz Biegała, et al.
Published: (2023-12-01)

CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair.
by: Esashi, F, et al.
Published: (2005)

The Influence of PARP, ATR, CHK1 Inhibitors on Premature Mitotic Entry and Genomic Instability in High-Grade Serous <i>BRCA<sup>MUT</sup></i> and <i>BRCA<sup>WT</sup></i> Ovarian Cancer Cells
by: Patrycja Gralewska, et al.
Published: (2022-06-01)

CHK1 inhibition exacerbates replication stress induced by IGF blockade
by: Wu, X, et al.
Published: (2021)

Phosphatase POPX2 interferes with cell cycle by interacting with Chk1
by: Kim, Pu Rum, et al.
Published: (2022)

Tight Chk1 Levels Control Replication Cluster Activation in Xenopus.
by: Marie Platel, et al.
Published: (2015-01-01)

Sensitization of Pancreatic Cancer Stem Cells to Gemcitabine by Chk1 Inhibition
by: Venkatasubbaiah A. Venkatesha, et al.
Published: (2012-06-01)

The Mre11 nuclease is critical for the sensitivity of cells to Chk1 inhibition.
by: Ruth Thompson, et al.
Published: (2012-01-01)