Intestinal type adenocarcinoma of the endometrium with signet ring cells, a rare aggressive variant
Objective: Intestinal type mucinous adenocarcinoma (iMACE) is a rare and unusual variant of mucinous carcinoma of the endometrium that can show focal features of poorly differentiated adenocarcinomas of gastric, pancreatic or intestinal origin by producing signet ring cells. To date, only two report...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-08-01
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| Series: | Gynecologic Oncology Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352578922001266 |
| _version_ | 1811222087522582528 |
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| author | Kieran Seay Bethany Bustamante Alexander Truskinovsky Andrew Menzin Gary L. Goldberg |
| author_facet | Kieran Seay Bethany Bustamante Alexander Truskinovsky Andrew Menzin Gary L. Goldberg |
| author_sort | Kieran Seay |
| collection | DOAJ |
| description | Objective: Intestinal type mucinous adenocarcinoma (iMACE) is a rare and unusual variant of mucinous carcinoma of the endometrium that can show focal features of poorly differentiated adenocarcinomas of gastric, pancreatic or intestinal origin by producing signet ring cells. To date, only two reported cases of signet ring cells as a morphological feature of iMACE have been reported. Alterations in E-cadherin expression have been linked to increased metastatic potential, tumor dedifferentiation, and deep myometrial invasion in endometrial carcinomas. The presence or absence of E-cadherin in iMACE with signet-ring cells has not been studied. Thus, we sought to analyze E-cadherin expression in this aggressive variant of endometrial carcinoma. Cases: Diagnosis of iMACE with signet ring cells was rendered with the aid of immunohistochemical staining and histological analysis. Average age of diagnosis was 72 with the presenting complaint of postmenopausal bleeding in all three women. Focal loss or weakly positive E-cadherin expression was seen in areas of signet-rings cell morphology in all three cases. Conclusion: This case report adds to the body of literature that demonstrates the aggressive nature of intestinal differentiation in the endometrium. In addition, this report suggests that the presence of signet-rings cells and loss of E-cadherin expression may render a poorer prognosis as seen in other parts of the body. |
| first_indexed | 2024-04-12T08:10:38Z |
| format | Article |
| id | doaj.art-e7c3ced2f09e41f78d9baaeab1d0bae0 |
| institution | Directory Open Access Journal |
| issn | 2352-5789 |
| language | English |
| last_indexed | 2024-04-12T08:10:38Z |
| publishDate | 2022-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Gynecologic Oncology Reports |
| spelling | doaj.art-e7c3ced2f09e41f78d9baaeab1d0bae02022-12-22T03:41:00ZengElsevierGynecologic Oncology Reports2352-57892022-08-0142101046Intestinal type adenocarcinoma of the endometrium with signet ring cells, a rare aggressive variantKieran Seay0Bethany Bustamante1Alexander Truskinovsky2Andrew Menzin3Gary L. Goldberg4Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Northwell Health, Zucker School of Medicine at Hofstra/Northwell, Long Island, NY, United StatesDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, Northwell Health, Zucker School of Medicine at Hofstra/Northwell, Long Island, NY, United StatesPathology and Laboratory Medicine, Northwell Health, Zucker School of Medicine at Hofstra/Northwell, Long Island, NY, United StatesDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, Northwell Health, Zucker School of Medicine at Hofstra/Northwell, Long Island, NY, United StatesDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, Northwell Health, Zucker School of Medicine at Hofstra/Northwell, Long Island, NY, United States; Corresponding author at: 270-05 76th 17 Avenue, New Hyde Park, NY 11040, United States.Objective: Intestinal type mucinous adenocarcinoma (iMACE) is a rare and unusual variant of mucinous carcinoma of the endometrium that can show focal features of poorly differentiated adenocarcinomas of gastric, pancreatic or intestinal origin by producing signet ring cells. To date, only two reported cases of signet ring cells as a morphological feature of iMACE have been reported. Alterations in E-cadherin expression have been linked to increased metastatic potential, tumor dedifferentiation, and deep myometrial invasion in endometrial carcinomas. The presence or absence of E-cadherin in iMACE with signet-ring cells has not been studied. Thus, we sought to analyze E-cadherin expression in this aggressive variant of endometrial carcinoma. Cases: Diagnosis of iMACE with signet ring cells was rendered with the aid of immunohistochemical staining and histological analysis. Average age of diagnosis was 72 with the presenting complaint of postmenopausal bleeding in all three women. Focal loss or weakly positive E-cadherin expression was seen in areas of signet-rings cell morphology in all three cases. Conclusion: This case report adds to the body of literature that demonstrates the aggressive nature of intestinal differentiation in the endometrium. In addition, this report suggests that the presence of signet-rings cells and loss of E-cadherin expression may render a poorer prognosis as seen in other parts of the body.http://www.sciencedirect.com/science/article/pii/S2352578922001266EndometriumIntestinal differentiationSignet-rings morphologyE-cadherin |
| spellingShingle | Kieran Seay Bethany Bustamante Alexander Truskinovsky Andrew Menzin Gary L. Goldberg Intestinal type adenocarcinoma of the endometrium with signet ring cells, a rare aggressive variant Gynecologic Oncology Reports Endometrium Intestinal differentiation Signet-rings morphology E-cadherin |
| title | Intestinal type adenocarcinoma of the endometrium with signet ring cells, a rare aggressive variant |
| title_full | Intestinal type adenocarcinoma of the endometrium with signet ring cells, a rare aggressive variant |
| title_fullStr | Intestinal type adenocarcinoma of the endometrium with signet ring cells, a rare aggressive variant |
| title_full_unstemmed | Intestinal type adenocarcinoma of the endometrium with signet ring cells, a rare aggressive variant |
| title_short | Intestinal type adenocarcinoma of the endometrium with signet ring cells, a rare aggressive variant |
| title_sort | intestinal type adenocarcinoma of the endometrium with signet ring cells a rare aggressive variant |
| topic | Endometrium Intestinal differentiation Signet-rings morphology E-cadherin |
| url | http://www.sciencedirect.com/science/article/pii/S2352578922001266 |
| work_keys_str_mv | AT kieranseay intestinaltypeadenocarcinomaoftheendometriumwithsignetringcellsarareaggressivevariant AT bethanybustamante intestinaltypeadenocarcinomaoftheendometriumwithsignetringcellsarareaggressivevariant AT alexandertruskinovsky intestinaltypeadenocarcinomaoftheendometriumwithsignetringcellsarareaggressivevariant AT andrewmenzin intestinaltypeadenocarcinomaoftheendometriumwithsignetringcellsarareaggressivevariant AT garylgoldberg intestinaltypeadenocarcinomaoftheendometriumwithsignetringcellsarareaggressivevariant |