New technologies in diagnosis of preinvasive cervical lesions
Results of efficiency assessment of different diagnosis for preinvasive cervical lesions are represented in the article. During investigation the retrospective analysis of 353 patient histories of women with cervical intraepithelial neoplasia (primary and recurrent), who have been observed in Ivanov...
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| Format: | Article |
| Language: | Russian |
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Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association"
2015-12-01
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| Series: | Biomedical Photonics |
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| Online Access: | https://www.pdt-journal.com/jour/article/view/68 |
| _version_ | 1797883745186873344 |
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| author | I. P. Aminodova |
| author_facet | I. P. Aminodova |
| author_sort | I. P. Aminodova |
| collection | DOAJ |
| description | Results of efficiency assessment of different diagnosis for preinvasive cervical lesions are represented in the article. During investigation the retrospective analysis of 353 patient histories of women with cervical intraepithelial neoplasia (primary and recurrent), who have been observed in Ivanovskiy regional oncological dispensary from 2002 to 2011, was performed. The accuracy rates of diagnosis of cervical intraepithelial neoplasia for one or several methods including cytological study, colposcopy and fluorescence cystoscopy were compared. Fluorescence diagnosis was performed with drug fotoditazin (LLC «VETA-GRAND», marketing authorisation №LS 001246) at dose of 1,0 mg/kg body weight. The final diagnosis was determined by results of histological study. The accuracy of cytological study accounted for 67,5–80,7%. Using colposcopy the exact diagnosis was determined in 67,9–74,4% of cases. Combination of cytological study with colposcopy improved the accuracy of diagnosis up to 82.1–88.9%. The superior results were for concurrent use of cytological study with colposcopy and fluorescence diagnosis – in such case the diagnosis was correct in 92,0–96,7% of patients. The analysis of results showed that using all methods of diagnosis the accuracy of diagnosis for recurrent cervical intraepithelial neoplasia was lower than for primary lesions. The decrease of diagnosis accuracy is probably related to previous diagnosis and therapeutic manipulations on cervix. Thus, multimodal diagnosis investigation with methods of fluorescence spectroscopy allows to improve accuracy of diagnosis for preinvasive cervical lesions. |
| first_indexed | 2024-04-10T03:55:30Z |
| format | Article |
| id | doaj.art-e7c40e56d7694e50afa9d73b6388e1af |
| institution | Directory Open Access Journal |
| issn | 2413-9432 |
| language | Russian |
| last_indexed | 2024-04-10T03:55:30Z |
| publishDate | 2015-12-01 |
| publisher | Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association" |
| record_format | Article |
| series | Biomedical Photonics |
| spelling | doaj.art-e7c40e56d7694e50afa9d73b6388e1af2023-03-13T07:12:30ZrusNon-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association"Biomedical Photonics2413-94322015-12-0144111610.24931/2413-9432-2015-4-4-11-1666New technologies in diagnosis of preinvasive cervical lesionsI. P. Aminodova0ОБУЗ «Ивановский областной онкологический диспансер», ООО «Клиника современной медицины», Иваново, РоссияResults of efficiency assessment of different diagnosis for preinvasive cervical lesions are represented in the article. During investigation the retrospective analysis of 353 patient histories of women with cervical intraepithelial neoplasia (primary and recurrent), who have been observed in Ivanovskiy regional oncological dispensary from 2002 to 2011, was performed. The accuracy rates of diagnosis of cervical intraepithelial neoplasia for one or several methods including cytological study, colposcopy and fluorescence cystoscopy were compared. Fluorescence diagnosis was performed with drug fotoditazin (LLC «VETA-GRAND», marketing authorisation №LS 001246) at dose of 1,0 mg/kg body weight. The final diagnosis was determined by results of histological study. The accuracy of cytological study accounted for 67,5–80,7%. Using colposcopy the exact diagnosis was determined in 67,9–74,4% of cases. Combination of cytological study with colposcopy improved the accuracy of diagnosis up to 82.1–88.9%. The superior results were for concurrent use of cytological study with colposcopy and fluorescence diagnosis – in such case the diagnosis was correct in 92,0–96,7% of patients. The analysis of results showed that using all methods of diagnosis the accuracy of diagnosis for recurrent cervical intraepithelial neoplasia was lower than for primary lesions. The decrease of diagnosis accuracy is probably related to previous diagnosis and therapeutic manipulations on cervix. Thus, multimodal diagnosis investigation with methods of fluorescence spectroscopy allows to improve accuracy of diagnosis for preinvasive cervical lesions.https://www.pdt-journal.com/jour/article/view/68дисплазия шейки маткифотодитазинфлуоресцентная спектроскопиядиагностика |
| spellingShingle | I. P. Aminodova New technologies in diagnosis of preinvasive cervical lesions Biomedical Photonics дисплазия шейки матки фотодитазин флуоресцентная спектроскопия диагностика |
| title | New technologies in diagnosis of preinvasive cervical lesions |
| title_full | New technologies in diagnosis of preinvasive cervical lesions |
| title_fullStr | New technologies in diagnosis of preinvasive cervical lesions |
| title_full_unstemmed | New technologies in diagnosis of preinvasive cervical lesions |
| title_short | New technologies in diagnosis of preinvasive cervical lesions |
| title_sort | new technologies in diagnosis of preinvasive cervical lesions |
| topic | дисплазия шейки матки фотодитазин флуоресцентная спектроскопия диагностика |
| url | https://www.pdt-journal.com/jour/article/view/68 |
| work_keys_str_mv | AT ipaminodova newtechnologiesindiagnosisofpreinvasivecervicallesions |