Suboptimal Baseline Serum Vitamin B12 Is Associated With Cognitive Decline in People With Alzheimer’s Disease Undergoing Cholinesterase Inhibitor Treatment
ObjectivesCholinesterase inhibitors (ChEIs) are the mainstream treatment for delaying cognitive decline in Alzheimer’s disease (AD). Low vitamin B12 is associated with cognitive dysfunction, and its supplementation has been applied as the treatment for certain types of reversible dementia. The prese...
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| Format: | Article |
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Frontiers Media S.A.
2018-05-01
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| Series: | Frontiers in Neurology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fneur.2018.00325/full |
| _version_ | 1818967486410784768 |
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| author | Hsiao Shan Cho Li Kai Huang Li Kai Huang Yao Tung Lee Yao Tung Lee Lung Chan Lung Chan Chien Tai Hong Chien Tai Hong |
| author_facet | Hsiao Shan Cho Li Kai Huang Li Kai Huang Yao Tung Lee Yao Tung Lee Lung Chan Lung Chan Chien Tai Hong Chien Tai Hong |
| author_sort | Hsiao Shan Cho |
| collection | DOAJ |
| description | ObjectivesCholinesterase inhibitors (ChEIs) are the mainstream treatment for delaying cognitive decline in Alzheimer’s disease (AD). Low vitamin B12 is associated with cognitive dysfunction, and its supplementation has been applied as the treatment for certain types of reversible dementia. The present study hypothesized that baseline serum vitamin B12 is associated with the deterioration of cognitive function in people with AD undergoing ChEI treatment.Materials and methodsBetween 2009 and 2016, medical records from 165 Taiwanese with mild to moderate AD who underwent ChEI treatment for at least 2 years were reviewed. Their baseline serum vitamin B12 levels were measured before treatment initiation. Their cognitive function was assessed using the Mini–Mental State Examination (MMSE) and Cognitive Abilities Screening Instrument (CASI). Student’s t test and multivariable logistic regression were used to analyze the association between cognitive decline and vitamin B12 level. Statistical analyses were performed using SPSS 19.0.ResultsOverall, 122 participants were women. Their median age was 76 years (ranging from 54 to 91). For people with optimal baseline vitamin B12 (above the median level of 436 ng/L), the rates of MMSE and CASI decline were 0.78 ± 1.28 and 2.84 ± 4.21 per year, respectively, which were significantly slower than those with suboptimal vitamin B12 (1.42 ± 1.67 and 4.94 ± 5.88 per year; p = 0.007 and 0.009, respectively). After adjustment for age, sex, education level, hypertension, diabetes, history of stroke, and baseline cognitive function, the baseline serum vitamin B12 level was negatively associated with MMSE and CASI decline.ConclusionSuboptimal baseline serum vitamin B12 level is associated with cognitive decline in people with AD undergoing ChEI treatment. |
| first_indexed | 2024-12-20T13:49:34Z |
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| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-20T13:49:34Z |
| publishDate | 2018-05-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neurology |
| spelling | doaj.art-e7c47910915b49bf94bf314513d1a4782022-12-21T19:38:33ZengFrontiers Media S.A.Frontiers in Neurology1664-22952018-05-01910.3389/fneur.2018.00325315480Suboptimal Baseline Serum Vitamin B12 Is Associated With Cognitive Decline in People With Alzheimer’s Disease Undergoing Cholinesterase Inhibitor TreatmentHsiao Shan Cho0Li Kai Huang1Li Kai Huang2Yao Tung Lee3Yao Tung Lee4Lung Chan5Lung Chan6Chien Tai Hong7Chien Tai Hong8Department of Neurology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, TaiwanDepartment of Neurology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, TaiwanGraduate Institute of Humanities in Medicine, Taipei Medical University, Taipei, TaiwanDepartment of Psychiatry, Shuang Ho Hospital, Taipei Medical University, New Taipei City, TaiwanDepartment of Psychiatry, School of Medicine, College of Medicine, Taipei Medical University, Taipei, TaiwanDepartment of Neurology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, TaiwanDepartment of Neurology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, TaiwanDepartment of Neurology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, TaiwanDepartment of Neurology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, TaiwanObjectivesCholinesterase inhibitors (ChEIs) are the mainstream treatment for delaying cognitive decline in Alzheimer’s disease (AD). Low vitamin B12 is associated with cognitive dysfunction, and its supplementation has been applied as the treatment for certain types of reversible dementia. The present study hypothesized that baseline serum vitamin B12 is associated with the deterioration of cognitive function in people with AD undergoing ChEI treatment.Materials and methodsBetween 2009 and 2016, medical records from 165 Taiwanese with mild to moderate AD who underwent ChEI treatment for at least 2 years were reviewed. Their baseline serum vitamin B12 levels were measured before treatment initiation. Their cognitive function was assessed using the Mini–Mental State Examination (MMSE) and Cognitive Abilities Screening Instrument (CASI). Student’s t test and multivariable logistic regression were used to analyze the association between cognitive decline and vitamin B12 level. Statistical analyses were performed using SPSS 19.0.ResultsOverall, 122 participants were women. Their median age was 76 years (ranging from 54 to 91). For people with optimal baseline vitamin B12 (above the median level of 436 ng/L), the rates of MMSE and CASI decline were 0.78 ± 1.28 and 2.84 ± 4.21 per year, respectively, which were significantly slower than those with suboptimal vitamin B12 (1.42 ± 1.67 and 4.94 ± 5.88 per year; p = 0.007 and 0.009, respectively). After adjustment for age, sex, education level, hypertension, diabetes, history of stroke, and baseline cognitive function, the baseline serum vitamin B12 level was negatively associated with MMSE and CASI decline.ConclusionSuboptimal baseline serum vitamin B12 level is associated with cognitive decline in people with AD undergoing ChEI treatment.http://journal.frontiersin.org/article/10.3389/fneur.2018.00325/fullcholinesterase inhibitorsAlzheimer’s diseasevitamin B12cognitionMini–Mental State Status ExaminationCognitive Abilities Screening Instrument |
| spellingShingle | Hsiao Shan Cho Li Kai Huang Li Kai Huang Yao Tung Lee Yao Tung Lee Lung Chan Lung Chan Chien Tai Hong Chien Tai Hong Suboptimal Baseline Serum Vitamin B12 Is Associated With Cognitive Decline in People With Alzheimer’s Disease Undergoing Cholinesterase Inhibitor Treatment Frontiers in Neurology cholinesterase inhibitors Alzheimer’s disease vitamin B12 cognition Mini–Mental State Status Examination Cognitive Abilities Screening Instrument |
| title | Suboptimal Baseline Serum Vitamin B12 Is Associated With Cognitive Decline in People With Alzheimer’s Disease Undergoing Cholinesterase Inhibitor Treatment |
| title_full | Suboptimal Baseline Serum Vitamin B12 Is Associated With Cognitive Decline in People With Alzheimer’s Disease Undergoing Cholinesterase Inhibitor Treatment |
| title_fullStr | Suboptimal Baseline Serum Vitamin B12 Is Associated With Cognitive Decline in People With Alzheimer’s Disease Undergoing Cholinesterase Inhibitor Treatment |
| title_full_unstemmed | Suboptimal Baseline Serum Vitamin B12 Is Associated With Cognitive Decline in People With Alzheimer’s Disease Undergoing Cholinesterase Inhibitor Treatment |
| title_short | Suboptimal Baseline Serum Vitamin B12 Is Associated With Cognitive Decline in People With Alzheimer’s Disease Undergoing Cholinesterase Inhibitor Treatment |
| title_sort | suboptimal baseline serum vitamin b12 is associated with cognitive decline in people with alzheimer s disease undergoing cholinesterase inhibitor treatment |
| topic | cholinesterase inhibitors Alzheimer’s disease vitamin B12 cognition Mini–Mental State Status Examination Cognitive Abilities Screening Instrument |
| url | http://journal.frontiersin.org/article/10.3389/fneur.2018.00325/full |
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