Concentrations of oocyte secreted GDF9 and BMP15 decrease with MII transition during human IVM

Concentrations of oocyte secreted GDF9 and BMP15 decrease with MII transition during human IVM

Abstract Background The suggested effects of the oocyte secreted GDF9 and BMP15 growth factors on oocyte maturation are currently based on recombinant proteins, and little is known about native GDF9 and BMP15 in humans. Methods Human immature cumulus-oocyte complexes (COCs) obtained in connection wi...

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Bibliographic Details
Main Authors: Jesús Cadenas, Susanne Elisabeth Pors, Ajay Kumar, Bhanu Kalra, Stine Gry Kristensen, Claus Yding Andersen, Linn Salto Mamsen
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Reproductive Biology and Endocrinology
Subjects:
GDF9
BMP15
BMP15 heterodimer
Cumulin
Ex-vivo collected oocytes
Online Access:https://doi.org/10.1186/s12958-022-01000-6

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