Lipid metabolism reprogramming and its potential targets in cancer
Abstract Reprogramming of lipid metabolism is a newly recognized hallmark of malignancy. Increased lipid uptake, storage and lipogenesis occur in a variety of cancers and contribute to rapid tumor growth. Lipids constitute the basic structure of membranes and also function as signaling molecules and...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-05-01
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| Series: | Cancer Communications |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s40880-018-0301-4 |
| _version_ | 1811340325480824832 |
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| author | Chunming Cheng Feng Geng Xiang Cheng Deliang Guo |
| author_facet | Chunming Cheng Feng Geng Xiang Cheng Deliang Guo |
| author_sort | Chunming Cheng |
| collection | DOAJ |
| description | Abstract Reprogramming of lipid metabolism is a newly recognized hallmark of malignancy. Increased lipid uptake, storage and lipogenesis occur in a variety of cancers and contribute to rapid tumor growth. Lipids constitute the basic structure of membranes and also function as signaling molecules and energy sources. Sterol regulatory element-binding proteins (SREBPs), a family of membrane-bound transcription factors in the endoplasmic reticulum, play a central role in the regulation of lipid metabolism. Recent studies have revealed that SREBPs are highly up-regulated in various cancers and promote tumor growth. SREBP cleavage-activating protein is a key transporter in the trafficking and activation of SREBPs as well as a critical glucose sensor, thus linking glucose metabolism and de novo lipid synthesis. Targeting altered lipid metabolic pathways has become a promising anti-cancer strategy. This review summarizes recent progress in our understanding of lipid metabolism regulation in malignancy, and highlights potential molecular targets and their inhibitors for cancer treatment. |
| first_indexed | 2024-04-13T18:39:21Z |
| format | Article |
| id | doaj.art-e7c703d8ea0e40f587040718edf91a09 |
| institution | Directory Open Access Journal |
| issn | 2523-3548 |
| language | English |
| last_indexed | 2024-04-13T18:39:21Z |
| publishDate | 2018-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Communications |
| spelling | doaj.art-e7c703d8ea0e40f587040718edf91a092022-12-22T02:34:46ZengWileyCancer Communications2523-35482018-05-0138111410.1186/s40880-018-0301-4Lipid metabolism reprogramming and its potential targets in cancerChunming Cheng0Feng Geng1Xiang Cheng2Deliang Guo3Department of Radiation Oncology, The Ohio State University James Comprehensive Cancer Center and College of MedicineDepartment of Radiation Oncology, The Ohio State University James Comprehensive Cancer Center and College of MedicineDepartment of Radiation Oncology, The Ohio State University James Comprehensive Cancer Center and College of MedicineDepartment of Radiation Oncology, The Ohio State University James Comprehensive Cancer Center and College of MedicineAbstract Reprogramming of lipid metabolism is a newly recognized hallmark of malignancy. Increased lipid uptake, storage and lipogenesis occur in a variety of cancers and contribute to rapid tumor growth. Lipids constitute the basic structure of membranes and also function as signaling molecules and energy sources. Sterol regulatory element-binding proteins (SREBPs), a family of membrane-bound transcription factors in the endoplasmic reticulum, play a central role in the regulation of lipid metabolism. Recent studies have revealed that SREBPs are highly up-regulated in various cancers and promote tumor growth. SREBP cleavage-activating protein is a key transporter in the trafficking and activation of SREBPs as well as a critical glucose sensor, thus linking glucose metabolism and de novo lipid synthesis. Targeting altered lipid metabolic pathways has become a promising anti-cancer strategy. This review summarizes recent progress in our understanding of lipid metabolism regulation in malignancy, and highlights potential molecular targets and their inhibitors for cancer treatment.http://link.springer.com/article/10.1186/s40880-018-0301-4Lipid metabolismCancerSCAPSREBPsFatty acidsCholesterol |
| spellingShingle | Chunming Cheng Feng Geng Xiang Cheng Deliang Guo Lipid metabolism reprogramming and its potential targets in cancer Cancer Communications Lipid metabolism Cancer SCAP SREBPs Fatty acids Cholesterol |
| title | Lipid metabolism reprogramming and its potential targets in cancer |
| title_full | Lipid metabolism reprogramming and its potential targets in cancer |
| title_fullStr | Lipid metabolism reprogramming and its potential targets in cancer |
| title_full_unstemmed | Lipid metabolism reprogramming and its potential targets in cancer |
| title_short | Lipid metabolism reprogramming and its potential targets in cancer |
| title_sort | lipid metabolism reprogramming and its potential targets in cancer |
| topic | Lipid metabolism Cancer SCAP SREBPs Fatty acids Cholesterol |
| url | http://link.springer.com/article/10.1186/s40880-018-0301-4 |
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