The role of targeting glucose metabolism in chondrocytes in the pathogenesis and therapeutic mechanisms of osteoarthritis: a narrative review
Osteoarthritis (OA) is a common degenerative joint disease that can affect almost any joint, mainly resulting in joint dysfunction and pain. Worldwide, OA affects more than 240 million people and is one of the leading causes of activity limitation in adults. However, the pathogenesis of OA remains e...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1319827/full |
| _version_ | 1797272587804344320 |
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| author | Peng Pi Liqing Zeng Zhipeng Zeng Keqiang Zong Keqiang Zong Bing Han Xizhe Bai Yan Wang |
| author_facet | Peng Pi Liqing Zeng Zhipeng Zeng Keqiang Zong Keqiang Zong Bing Han Xizhe Bai Yan Wang |
| author_sort | Peng Pi |
| collection | DOAJ |
| description | Osteoarthritis (OA) is a common degenerative joint disease that can affect almost any joint, mainly resulting in joint dysfunction and pain. Worldwide, OA affects more than 240 million people and is one of the leading causes of activity limitation in adults. However, the pathogenesis of OA remains elusive, resulting in the lack of well-established clinical treatment strategies. Recently, energy metabolism alterations have provided new insights into the pathogenesis of OA. Accumulating evidence indicates that glucose metabolism plays a key role in maintaining cartilage homeostasis. Disorders of glucose metabolism can lead to chondrocyte hypertrophy and extracellular matrix degradation, and promote the occurrence and development of OA. This article systematically summarizes the regulatory effects of different enzymes and factors related to glucose metabolism in OA, as well as the mechanism and potential of various substances in the treatment of OA by affecting glucose metabolism. This provides a theoretical basis for a better understanding of the mechanism of OA progression and the development of optimal prevention and treatment strategies. |
| first_indexed | 2024-03-07T14:31:30Z |
| format | Article |
| id | doaj.art-e7c8c397bb644ac6bdd27d2611bff469 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-07T14:31:30Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-e7c8c397bb644ac6bdd27d2611bff4692024-03-06T04:54:44ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-03-011510.3389/fendo.2024.13198271319827The role of targeting glucose metabolism in chondrocytes in the pathogenesis and therapeutic mechanisms of osteoarthritis: a narrative reviewPeng Pi0Liqing Zeng1Zhipeng Zeng2Keqiang Zong3Keqiang Zong4Bing Han5Xizhe Bai6Yan Wang7School of Sports Medicine and Rehabilitation, Beijing Sport University, Beijing, ChinaSchool of Sports Medicine and Rehabilitation, Beijing Sport University, Beijing, ChinaSchool of Sports Medicine and Rehabilitation, Beijing Sport University, Beijing, ChinaSchool of Sports Medicine and Rehabilitation, Beijing Sport University, Beijing, ChinaSchool of Physical Education, Qiqihar University, Heilongjiang, Qiqihar, ChinaSchool of Sports Medicine and Rehabilitation, Beijing Sport University, Beijing, ChinaCollege of Physical Education and Health, East China Normal University, Shanghai, ChinaSchool of Sports Medicine and Rehabilitation, Beijing Sport University, Beijing, ChinaOsteoarthritis (OA) is a common degenerative joint disease that can affect almost any joint, mainly resulting in joint dysfunction and pain. Worldwide, OA affects more than 240 million people and is one of the leading causes of activity limitation in adults. However, the pathogenesis of OA remains elusive, resulting in the lack of well-established clinical treatment strategies. Recently, energy metabolism alterations have provided new insights into the pathogenesis of OA. Accumulating evidence indicates that glucose metabolism plays a key role in maintaining cartilage homeostasis. Disorders of glucose metabolism can lead to chondrocyte hypertrophy and extracellular matrix degradation, and promote the occurrence and development of OA. This article systematically summarizes the regulatory effects of different enzymes and factors related to glucose metabolism in OA, as well as the mechanism and potential of various substances in the treatment of OA by affecting glucose metabolism. This provides a theoretical basis for a better understanding of the mechanism of OA progression and the development of optimal prevention and treatment strategies.https://www.frontiersin.org/articles/10.3389/fendo.2024.1319827/fullosteoarthritisglucose metabolismcartilageglycolysistherapeutic |
| spellingShingle | Peng Pi Liqing Zeng Zhipeng Zeng Keqiang Zong Keqiang Zong Bing Han Xizhe Bai Yan Wang The role of targeting glucose metabolism in chondrocytes in the pathogenesis and therapeutic mechanisms of osteoarthritis: a narrative review Frontiers in Endocrinology osteoarthritis glucose metabolism cartilage glycolysis therapeutic |
| title | The role of targeting glucose metabolism in chondrocytes in the pathogenesis and therapeutic mechanisms of osteoarthritis: a narrative review |
| title_full | The role of targeting glucose metabolism in chondrocytes in the pathogenesis and therapeutic mechanisms of osteoarthritis: a narrative review |
| title_fullStr | The role of targeting glucose metabolism in chondrocytes in the pathogenesis and therapeutic mechanisms of osteoarthritis: a narrative review |
| title_full_unstemmed | The role of targeting glucose metabolism in chondrocytes in the pathogenesis and therapeutic mechanisms of osteoarthritis: a narrative review |
| title_short | The role of targeting glucose metabolism in chondrocytes in the pathogenesis and therapeutic mechanisms of osteoarthritis: a narrative review |
| title_sort | role of targeting glucose metabolism in chondrocytes in the pathogenesis and therapeutic mechanisms of osteoarthritis a narrative review |
| topic | osteoarthritis glucose metabolism cartilage glycolysis therapeutic |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1319827/full |
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