Prognostic Value of Platelet-to-Lymphocyte Ratio Combined with CHA2DS2-VASc Score for Nonvalvular Atrial Fibrillation Induced Cardiogenic Cerebral Embolism
Qian Fan,1,* Ling Gao,1,* Zhiquan Wang,2,* Fabrice Yves Ndjana Lessomo,2 Gang Wang1 1Department of Cardiology, The Second Affiliated Hospital of Shandong First Medical University, Taian, Shandong, People’s Republic of China; 2Department of Cardiology, Zhongnan Hospital of Wuh...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2023-12-01
|
| Series: | Journal of Inflammation Research |
| Subjects: | |
| Online Access: | https://www.dovepress.com/prognostic-value-of-platelet-to-lymphocyte-ratio-combined-with-cha2ds2-peer-reviewed-fulltext-article-JIR |
| _version_ | 1797401182511038464 |
|---|---|
| author | Fan Q Gao L Wang Z Ndjana Lessomo FY Wang G |
| author_facet | Fan Q Gao L Wang Z Ndjana Lessomo FY Wang G |
| author_sort | Fan Q |
| collection | DOAJ |
| description | Qian Fan,1,* Ling Gao,1,* Zhiquan Wang,2,* Fabrice Yves Ndjana Lessomo,2 Gang Wang1 1Department of Cardiology, The Second Affiliated Hospital of Shandong First Medical University, Taian, Shandong, People’s Republic of China; 2Department of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, People’s Republic of China*These authors contributed equally to this workCorrespondence: Gang Wang, Email cardio9090@sina.comAim: To determine the predictive significance of the platelet-to-lymphocyte ratio (PLR) combined with the CHA2DS2-VASc score for cardiogenic cerebral embolism (CCE) in patients with nonvalvular atrial fibrillation (NVAF).Methods: A total of 553 patients with NVAF were included in this retrospective study. The general data, PLR, CHA2DS2-VASc score and echocardiography indicators were compared. The risk factors for CCE and the predictive value of PLR and CHA2DS2-VASc were analyzed. Stratified analysis was performed based on the cut-off value. Least absolute shrinkage and selection operator (LASSO) regression analysis was utilized to build a model. The relationship between risk score and different anticoagulants was evaluated.Results: Multiple regression analysis showed hypertension (OR=3.95, 95% CI=2.12– 7.35, p=1.40× 10− 5), diabetes mellitus (OR=2.95, 95% CI=1.57– 5.58, p=7.65× 10− 4), PLR (OR=1.01, 95% CI=1.00– 1.01, p< 10− 6), creatinine level (OR=1.01, 95% CI=1.00– 1.02, p=7.44× 10− 3), left atrial diameter (LAD) (OR=1.90, 95% CI=1.13– 3.19, p=1.51× 10− 2), ejection fraction (EF) (OR=0.93, 95% CI=0.87– 0.98, p=8.06× 10− 3) and CHA2DS2-VASc score (OR=3.79, 95% CI=2.95– 4.85, p< 10− 6) were independent risk factors for CCE. A one-way linear analysis also showed the above seven indexes were significantly correlated with CCE (F=56.4, p< 10− 6). The area under the receiver operating characteristic (ROC) curve of PLR and CHA2DS2-VASc score was 0.760 (95% CI:0.721– 0.800), and 0.855 (95% CI: 0.824– 0.886), respectively. Pearson correlation analysis showed that PLR was correlated with CHA2DS2-VASc score (r=0.331, p< 10− 6). Stratified analysis indicated there was a positive correlation between different risk group (p< 10− 6). Using the LASSO model, a composite indicator displayed differential power for distinguishing CCE with an AUC value of 0.884 (95% CI: 0.857– 0.911). Patients with dabigatran and rivaroxaban exhibited higher risk score than those with warfarin (warfarin vs dabigatran, p=1.40× 10− 2; warfarin vs rivaroxaban p=3.00× 10− 3).Conclusion: PLR and CHA2DS2-VASc score are independent risk factors for CCE with NVAF, and the combination of the two indices can improve the prediction of CCE.Keywords: NVAF, CCE, PLR, CHA2DS2-VASc score, LASSO model |
| first_indexed | 2024-03-09T02:06:11Z |
| format | Article |
| id | doaj.art-e7c94e582e9941fca91094bce56b731d |
| institution | Directory Open Access Journal |
| issn | 1178-7031 |
| language | English |
| last_indexed | 2024-03-09T02:06:11Z |
| publishDate | 2023-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Inflammation Research |
| spelling | doaj.art-e7c94e582e9941fca91094bce56b731d2023-12-07T18:03:42ZengDove Medical PressJournal of Inflammation Research1178-70312023-12-01Volume 165937594788789Prognostic Value of Platelet-to-Lymphocyte Ratio Combined with CHA2DS2-VASc Score for Nonvalvular Atrial Fibrillation Induced Cardiogenic Cerebral EmbolismFan QGao LWang ZNdjana Lessomo FYWang GQian Fan,1,* Ling Gao,1,* Zhiquan Wang,2,* Fabrice Yves Ndjana Lessomo,2 Gang Wang1 1Department of Cardiology, The Second Affiliated Hospital of Shandong First Medical University, Taian, Shandong, People’s Republic of China; 2Department of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, People’s Republic of China*These authors contributed equally to this workCorrespondence: Gang Wang, Email cardio9090@sina.comAim: To determine the predictive significance of the platelet-to-lymphocyte ratio (PLR) combined with the CHA2DS2-VASc score for cardiogenic cerebral embolism (CCE) in patients with nonvalvular atrial fibrillation (NVAF).Methods: A total of 553 patients with NVAF were included in this retrospective study. The general data, PLR, CHA2DS2-VASc score and echocardiography indicators were compared. The risk factors for CCE and the predictive value of PLR and CHA2DS2-VASc were analyzed. Stratified analysis was performed based on the cut-off value. Least absolute shrinkage and selection operator (LASSO) regression analysis was utilized to build a model. The relationship between risk score and different anticoagulants was evaluated.Results: Multiple regression analysis showed hypertension (OR=3.95, 95% CI=2.12– 7.35, p=1.40× 10− 5), diabetes mellitus (OR=2.95, 95% CI=1.57– 5.58, p=7.65× 10− 4), PLR (OR=1.01, 95% CI=1.00– 1.01, p< 10− 6), creatinine level (OR=1.01, 95% CI=1.00– 1.02, p=7.44× 10− 3), left atrial diameter (LAD) (OR=1.90, 95% CI=1.13– 3.19, p=1.51× 10− 2), ejection fraction (EF) (OR=0.93, 95% CI=0.87– 0.98, p=8.06× 10− 3) and CHA2DS2-VASc score (OR=3.79, 95% CI=2.95– 4.85, p< 10− 6) were independent risk factors for CCE. A one-way linear analysis also showed the above seven indexes were significantly correlated with CCE (F=56.4, p< 10− 6). The area under the receiver operating characteristic (ROC) curve of PLR and CHA2DS2-VASc score was 0.760 (95% CI:0.721– 0.800), and 0.855 (95% CI: 0.824– 0.886), respectively. Pearson correlation analysis showed that PLR was correlated with CHA2DS2-VASc score (r=0.331, p< 10− 6). Stratified analysis indicated there was a positive correlation between different risk group (p< 10− 6). Using the LASSO model, a composite indicator displayed differential power for distinguishing CCE with an AUC value of 0.884 (95% CI: 0.857– 0.911). Patients with dabigatran and rivaroxaban exhibited higher risk score than those with warfarin (warfarin vs dabigatran, p=1.40× 10− 2; warfarin vs rivaroxaban p=3.00× 10− 3).Conclusion: PLR and CHA2DS2-VASc score are independent risk factors for CCE with NVAF, and the combination of the two indices can improve the prediction of CCE.Keywords: NVAF, CCE, PLR, CHA2DS2-VASc score, LASSO modelhttps://www.dovepress.com/prognostic-value-of-platelet-to-lymphocyte-ratio-combined-with-cha2ds2-peer-reviewed-fulltext-article-JIRnvafcceplrcha2ds2-vasc scorelasso model |
| spellingShingle | Fan Q Gao L Wang Z Ndjana Lessomo FY Wang G Prognostic Value of Platelet-to-Lymphocyte Ratio Combined with CHA2DS2-VASc Score for Nonvalvular Atrial Fibrillation Induced Cardiogenic Cerebral Embolism Journal of Inflammation Research nvaf cce plr cha2ds2-vasc score lasso model |
| title | Prognostic Value of Platelet-to-Lymphocyte Ratio Combined with CHA2DS2-VASc Score for Nonvalvular Atrial Fibrillation Induced Cardiogenic Cerebral Embolism |
| title_full | Prognostic Value of Platelet-to-Lymphocyte Ratio Combined with CHA2DS2-VASc Score for Nonvalvular Atrial Fibrillation Induced Cardiogenic Cerebral Embolism |
| title_fullStr | Prognostic Value of Platelet-to-Lymphocyte Ratio Combined with CHA2DS2-VASc Score for Nonvalvular Atrial Fibrillation Induced Cardiogenic Cerebral Embolism |
| title_full_unstemmed | Prognostic Value of Platelet-to-Lymphocyte Ratio Combined with CHA2DS2-VASc Score for Nonvalvular Atrial Fibrillation Induced Cardiogenic Cerebral Embolism |
| title_short | Prognostic Value of Platelet-to-Lymphocyte Ratio Combined with CHA2DS2-VASc Score for Nonvalvular Atrial Fibrillation Induced Cardiogenic Cerebral Embolism |
| title_sort | prognostic value of platelet to lymphocyte ratio combined with cha2ds2 vasc score for nonvalvular atrial fibrillation induced cardiogenic cerebral embolism |
| topic | nvaf cce plr cha2ds2-vasc score lasso model |
| url | https://www.dovepress.com/prognostic-value-of-platelet-to-lymphocyte-ratio-combined-with-cha2ds2-peer-reviewed-fulltext-article-JIR |
| work_keys_str_mv | AT fanq prognosticvalueofplatelettolymphocyteratiocombinedwithcha2ds2vascscorefornonvalvularatrialfibrillationinducedcardiogeniccerebralembolism AT gaol prognosticvalueofplatelettolymphocyteratiocombinedwithcha2ds2vascscorefornonvalvularatrialfibrillationinducedcardiogeniccerebralembolism AT wangz prognosticvalueofplatelettolymphocyteratiocombinedwithcha2ds2vascscorefornonvalvularatrialfibrillationinducedcardiogeniccerebralembolism AT ndjanalessomofy prognosticvalueofplatelettolymphocyteratiocombinedwithcha2ds2vascscorefornonvalvularatrialfibrillationinducedcardiogeniccerebralembolism AT wangg prognosticvalueofplatelettolymphocyteratiocombinedwithcha2ds2vascscorefornonvalvularatrialfibrillationinducedcardiogeniccerebralembolism |