Induction of systemic immunity through nasal-associated lymphoid tissue (NALT) of mice intranasally immunized with Brucella abortus malate dehydrogenase-loaded chitosan nanoparticles.

Infection with Brucella abortus causes contagious zoonosis, brucellosis, and leads to abortion in animals and chronic illness in humans. Chitosan nanoparticles (CNs), biocompatible and nontoxic polymers, acts as a mucosal adjuvant. In our previous study, B. abortus malate dehydrogenase (Mdh) was loa...

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Bibliografische gegevens
Hoofdauteurs: Soojin Shim, Sang Hee Soh, Young Bin Im, Choonghyun Ahn, Hong-Tae Park, Hyun-Eui Park, Woo Bin Park, Suji Kim, Han Sang Yoo
Formaat: Artikel
Taal:English
Gepubliceerd in: Public Library of Science (PLoS) 2020-01-01
Reeks:PLoS ONE
Online toegang:https://doi.org/10.1371/journal.pone.0228463