Microfluidic-Based Non-Invasive Wearable Biosensors for Real-Time Monitoring of Sweat Biomarkers
Wearable biosensors are attracting great interest thanks to their high potential for providing clinical-diagnostic information in real time, exploiting non-invasive sampling of biofluids. In this context, sweat has been demonstrated to contain physiologically relevant biomarkers, even if it has not...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-01-01
|
| Series: | Biosensors |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6374/14/1/29 |
| _version_ | 1797344518690832384 |
|---|---|
| author | Seyedeh Rojin Shariati Pour Donato Calabria Afsaneh Emamiamin Elisa Lazzarini Andrea Pace Massimo Guardigli Martina Zangheri Mara Mirasoli |
| author_facet | Seyedeh Rojin Shariati Pour Donato Calabria Afsaneh Emamiamin Elisa Lazzarini Andrea Pace Massimo Guardigli Martina Zangheri Mara Mirasoli |
| author_sort | Seyedeh Rojin Shariati Pour |
| collection | DOAJ |
| description | Wearable biosensors are attracting great interest thanks to their high potential for providing clinical-diagnostic information in real time, exploiting non-invasive sampling of biofluids. In this context, sweat has been demonstrated to contain physiologically relevant biomarkers, even if it has not been exhaustively exploited till now. This biofluid has started to gain attention thanks to the applications offered by wearable biosensors, as it is easily collectable and can be used for continuous monitoring of some parameters. Several studies have reported electrochemical and optical biosensing strategies integrated with flexible, biocompatible, and innovative materials as platforms for biospecific recognition reactions. Furthermore, sampling systems as well as the transport of fluids by microfluidics have been implemented into portable and compact biosensors to improve the wearability of the overall analytical device. In this review, we report and discuss recent pioneering works about the development of sweat sensing technologies, focusing on opportunities and open issues that can be decisive for their applications in routine-personalized healthcare practices. |
| first_indexed | 2024-03-08T11:03:46Z |
| format | Article |
| id | doaj.art-e7cccad693974d5098c5dbfb0f2ae4b1 |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-03-08T11:03:46Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-e7cccad693974d5098c5dbfb0f2ae4b12024-01-26T15:23:08ZengMDPI AGBiosensors2079-63742024-01-011412910.3390/bios14010029Microfluidic-Based Non-Invasive Wearable Biosensors for Real-Time Monitoring of Sweat BiomarkersSeyedeh Rojin Shariati Pour0Donato Calabria1Afsaneh Emamiamin2Elisa Lazzarini3Andrea Pace4Massimo Guardigli5Martina Zangheri6Mara Mirasoli7Department of Chemistry “Giacomo Ciamician”, Alma Mater Studiorum, University of Bologna, Tecnopolo di Rimini, Via Dario Campana 71, I-47922 Rimini, ItalyDepartment of Chemistry “Giacomo Ciamician”, Alma Mater Studiorum, University of Bologna, Via Francesco Selmi 2, I-40126 Bologna, ItalyDepartment of Chemistry “Giacomo Ciamician”, Alma Mater Studiorum, University of Bologna, Tecnopolo di Rimini, Via Dario Campana 71, I-47922 Rimini, ItalyDepartment of Chemistry “Giacomo Ciamician”, Alma Mater Studiorum, University of Bologna, Via Francesco Selmi 2, I-40126 Bologna, ItalyDepartment of Chemistry “Giacomo Ciamician”, Alma Mater Studiorum, University of Bologna, Via Francesco Selmi 2, I-40126 Bologna, ItalyDepartment of Chemistry “Giacomo Ciamician”, Alma Mater Studiorum, University of Bologna, Via Francesco Selmi 2, I-40126 Bologna, ItalyDepartment of Chemistry “Giacomo Ciamician”, Alma Mater Studiorum, University of Bologna, Tecnopolo di Rimini, Via Dario Campana 71, I-47922 Rimini, ItalyDepartment of Chemistry “Giacomo Ciamician”, Alma Mater Studiorum, University of Bologna, Tecnopolo di Rimini, Via Dario Campana 71, I-47922 Rimini, ItalyWearable biosensors are attracting great interest thanks to their high potential for providing clinical-diagnostic information in real time, exploiting non-invasive sampling of biofluids. In this context, sweat has been demonstrated to contain physiologically relevant biomarkers, even if it has not been exhaustively exploited till now. This biofluid has started to gain attention thanks to the applications offered by wearable biosensors, as it is easily collectable and can be used for continuous monitoring of some parameters. Several studies have reported electrochemical and optical biosensing strategies integrated with flexible, biocompatible, and innovative materials as platforms for biospecific recognition reactions. Furthermore, sampling systems as well as the transport of fluids by microfluidics have been implemented into portable and compact biosensors to improve the wearability of the overall analytical device. In this review, we report and discuss recent pioneering works about the development of sweat sensing technologies, focusing on opportunities and open issues that can be decisive for their applications in routine-personalized healthcare practices.https://www.mdpi.com/2079-6374/14/1/29wearable biosensorspoint-of-caresweatcolorimetric assayelectrochemical assayenzymatic assay |
| spellingShingle | Seyedeh Rojin Shariati Pour Donato Calabria Afsaneh Emamiamin Elisa Lazzarini Andrea Pace Massimo Guardigli Martina Zangheri Mara Mirasoli Microfluidic-Based Non-Invasive Wearable Biosensors for Real-Time Monitoring of Sweat Biomarkers Biosensors wearable biosensors point-of-care sweat colorimetric assay electrochemical assay enzymatic assay |
| title | Microfluidic-Based Non-Invasive Wearable Biosensors for Real-Time Monitoring of Sweat Biomarkers |
| title_full | Microfluidic-Based Non-Invasive Wearable Biosensors for Real-Time Monitoring of Sweat Biomarkers |
| title_fullStr | Microfluidic-Based Non-Invasive Wearable Biosensors for Real-Time Monitoring of Sweat Biomarkers |
| title_full_unstemmed | Microfluidic-Based Non-Invasive Wearable Biosensors for Real-Time Monitoring of Sweat Biomarkers |
| title_short | Microfluidic-Based Non-Invasive Wearable Biosensors for Real-Time Monitoring of Sweat Biomarkers |
| title_sort | microfluidic based non invasive wearable biosensors for real time monitoring of sweat biomarkers |
| topic | wearable biosensors point-of-care sweat colorimetric assay electrochemical assay enzymatic assay |
| url | https://www.mdpi.com/2079-6374/14/1/29 |
| work_keys_str_mv | AT seyedehrojinshariatipour microfluidicbasednoninvasivewearablebiosensorsforrealtimemonitoringofsweatbiomarkers AT donatocalabria microfluidicbasednoninvasivewearablebiosensorsforrealtimemonitoringofsweatbiomarkers AT afsanehemamiamin microfluidicbasednoninvasivewearablebiosensorsforrealtimemonitoringofsweatbiomarkers AT elisalazzarini microfluidicbasednoninvasivewearablebiosensorsforrealtimemonitoringofsweatbiomarkers AT andreapace microfluidicbasednoninvasivewearablebiosensorsforrealtimemonitoringofsweatbiomarkers AT massimoguardigli microfluidicbasednoninvasivewearablebiosensorsforrealtimemonitoringofsweatbiomarkers AT martinazangheri microfluidicbasednoninvasivewearablebiosensorsforrealtimemonitoringofsweatbiomarkers AT maramirasoli microfluidicbasednoninvasivewearablebiosensorsforrealtimemonitoringofsweatbiomarkers |