Live and Heat-Inactivated <i>Streptococcus thermophilus</i> MN-ZLW-002 Mediate the Gut–Brain Axis, Alleviating Cognitive Dysfunction in APP/PS1 Mice
Research on regulating brain functions with probiotics and postbiotics through the gut–brain axis is attracting attention, offering the possibility of adjuvant therapy for Alzheimer’s disease (AD). Three-month-old male APP/PS1 mice were gavaged with live and heat-inactivated <i>S. thermophilus...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/16/6/844 |
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| author | Yujie Zhang Yimei Wang Zhimo Zhou Yang Yang Jincheng Zhao Xiaohong Kang Zhouyong Li Xi Shen Fang He Ruyue Cheng |
| author_facet | Yujie Zhang Yimei Wang Zhimo Zhou Yang Yang Jincheng Zhao Xiaohong Kang Zhouyong Li Xi Shen Fang He Ruyue Cheng |
| author_sort | Yujie Zhang |
| collection | DOAJ |
| description | Research on regulating brain functions with probiotics and postbiotics through the gut–brain axis is attracting attention, offering the possibility of adjuvant therapy for Alzheimer’s disease (AD). Three-month-old male APP/PS1 mice were gavaged with live and heat-inactivated <i>S. thermophilus</i> MN-002 for three months. This study demonstrated that live and heat-inactivated <i>S. thermophilus</i> MN-002 improved cognitive dysfunctions in APP/PS1 mice, especially in spatial memory. However, the main effects of live <i>S. thermophilus</i> MN-002 directly altered the intestinal microbiota composition and increased serum IL-1β and IL-6. Heat-inactivated <i>S. thermophilus</i> MN-002 increased colonic propionic acid levels and enhanced the hippocampus’s antioxidant capacity. Furthermore, the changes were more obvious in the high-dose group, such as astrogliosis in the hippocampus. These results indicate that different forms and doses of the same strain, <i>S. thermophilus</i> MN-002, can partly improve cognitive functions in AD model mice via the gut–brain axis. |
| first_indexed | 2024-04-24T17:57:43Z |
| format | Article |
| id | doaj.art-e7ce74248f8c49bfb333eece03c79214 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-04-24T17:57:43Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-e7ce74248f8c49bfb333eece03c792142024-03-27T13:58:15ZengMDPI AGNutrients2072-66432024-03-0116684410.3390/nu16060844Live and Heat-Inactivated <i>Streptococcus thermophilus</i> MN-ZLW-002 Mediate the Gut–Brain Axis, Alleviating Cognitive Dysfunction in APP/PS1 MiceYujie Zhang0Yimei Wang1Zhimo Zhou2Yang Yang3Jincheng Zhao4Xiaohong Kang5Zhouyong Li6Xi Shen7Fang He8Ruyue Cheng9Department of Nutrition and Food Hygiene, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Nutrition and Food Hygiene, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Nutrition and Food Hygiene, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Nutrition and Food Hygiene, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Nutrition and Food Hygiene, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, ChinaGlobal R&D Innovation Center, Inner Mongolia Mengniu Dairy (Group) Co., Ltd., Hohhot 011050, ChinaGlobal R&D Innovation Center, Inner Mongolia Mengniu Dairy (Group) Co., Ltd., Hohhot 011050, ChinaDepartment of Nutrition and Food Hygiene, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Nutrition and Food Hygiene, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Nutrition and Food Hygiene, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, ChinaResearch on regulating brain functions with probiotics and postbiotics through the gut–brain axis is attracting attention, offering the possibility of adjuvant therapy for Alzheimer’s disease (AD). Three-month-old male APP/PS1 mice were gavaged with live and heat-inactivated <i>S. thermophilus</i> MN-002 for three months. This study demonstrated that live and heat-inactivated <i>S. thermophilus</i> MN-002 improved cognitive dysfunctions in APP/PS1 mice, especially in spatial memory. However, the main effects of live <i>S. thermophilus</i> MN-002 directly altered the intestinal microbiota composition and increased serum IL-1β and IL-6. Heat-inactivated <i>S. thermophilus</i> MN-002 increased colonic propionic acid levels and enhanced the hippocampus’s antioxidant capacity. Furthermore, the changes were more obvious in the high-dose group, such as astrogliosis in the hippocampus. These results indicate that different forms and doses of the same strain, <i>S. thermophilus</i> MN-002, can partly improve cognitive functions in AD model mice via the gut–brain axis.https://www.mdpi.com/2072-6643/16/6/844Alzheimer’s diseasegut microbiotaprobioticspostbiotics |
| spellingShingle | Yujie Zhang Yimei Wang Zhimo Zhou Yang Yang Jincheng Zhao Xiaohong Kang Zhouyong Li Xi Shen Fang He Ruyue Cheng Live and Heat-Inactivated <i>Streptococcus thermophilus</i> MN-ZLW-002 Mediate the Gut–Brain Axis, Alleviating Cognitive Dysfunction in APP/PS1 Mice Nutrients Alzheimer’s disease gut microbiota probiotics postbiotics |
| title | Live and Heat-Inactivated <i>Streptococcus thermophilus</i> MN-ZLW-002 Mediate the Gut–Brain Axis, Alleviating Cognitive Dysfunction in APP/PS1 Mice |
| title_full | Live and Heat-Inactivated <i>Streptococcus thermophilus</i> MN-ZLW-002 Mediate the Gut–Brain Axis, Alleviating Cognitive Dysfunction in APP/PS1 Mice |
| title_fullStr | Live and Heat-Inactivated <i>Streptococcus thermophilus</i> MN-ZLW-002 Mediate the Gut–Brain Axis, Alleviating Cognitive Dysfunction in APP/PS1 Mice |
| title_full_unstemmed | Live and Heat-Inactivated <i>Streptococcus thermophilus</i> MN-ZLW-002 Mediate the Gut–Brain Axis, Alleviating Cognitive Dysfunction in APP/PS1 Mice |
| title_short | Live and Heat-Inactivated <i>Streptococcus thermophilus</i> MN-ZLW-002 Mediate the Gut–Brain Axis, Alleviating Cognitive Dysfunction in APP/PS1 Mice |
| title_sort | live and heat inactivated i streptococcus thermophilus i mn zlw 002 mediate the gut brain axis alleviating cognitive dysfunction in app ps1 mice |
| topic | Alzheimer’s disease gut microbiota probiotics postbiotics |
| url | https://www.mdpi.com/2072-6643/16/6/844 |
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