UV Radiation and Its Relation to DNA Methylation in Epidermal Cells: A Review
DNA methylation is the most studied epigenetic mark, and it can be altered by environmental factors. Among these factors, ultraviolet radiation (UV) is little explored within this context. While the relationship between UV radiation and DNA mutations is clear, little is known about the relationship...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | Epigenomes |
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| Online Access: | https://www.mdpi.com/2075-4655/4/4/23 |
| _version_ | 1827705158275956736 |
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| author | Naila Francis Paulo de Oliveira Beatriz Fernandes de Souza Marina de Castro Coêlho |
| author_facet | Naila Francis Paulo de Oliveira Beatriz Fernandes de Souza Marina de Castro Coêlho |
| author_sort | Naila Francis Paulo de Oliveira |
| collection | DOAJ |
| description | DNA methylation is the most studied epigenetic mark, and it can be altered by environmental factors. Among these factors, ultraviolet radiation (UV) is little explored within this context. While the relationship between UV radiation and DNA mutations is clear, little is known about the relationship between UV radiation and epimutations. The present study aimed to perform a literature review to determine the influence of artificial or natural (solar) UV radiation on the global and site-specific methylation profile of epidermal cells. A systematic review of the literature was carried out using the databases PubMed, Scopus, Cochrane, and Web of Science. Observational and intervention studies in cultured cells and animal or human models were included. Most studies showed a relationship between UV radiation and changes in the methylation profile, both global and site-specific. Hypermethylation and hypomethylation changes were detected, which varied according to the studied CpG site. In conclusion, UV radiation can alter the DNA methylation profile in epidermal cells derived from the skin. These data can be used as potential biomarkers for environmental exposure and skin diseases, in addition to being targets for treatments. On the other hand, UV radiation (phototherapy) can also be used as a tool to treat skin diseases. Thus, the data suggest that epigenetic homeostasis can be disrupted or restored by exposure to UV radiation according to the applied wavelength. |
| first_indexed | 2024-03-10T15:56:21Z |
| format | Article |
| id | doaj.art-e7ce8a97f36c4a9ca0da2bccd5d60e93 |
| institution | Directory Open Access Journal |
| issn | 2075-4655 |
| language | English |
| last_indexed | 2024-03-10T15:56:21Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Epigenomes |
| spelling | doaj.art-e7ce8a97f36c4a9ca0da2bccd5d60e932023-11-20T15:42:12ZengMDPI AGEpigenomes2075-46552020-09-01442310.3390/epigenomes4040023UV Radiation and Its Relation to DNA Methylation in Epidermal Cells: A ReviewNaila Francis Paulo de Oliveira0Beatriz Fernandes de Souza1Marina de Castro Coêlho2Departamento de Biologia Molecular, Centro de Ciências Exatas e da Natureza, Universidade Federal da Paraíba—UFPB, João Pessoa 58051-900, BrazilDepartamento de Biologia Molecular, Centro de Ciências Exatas e da Natureza, Universidade Federal da Paraíba—UFPB, João Pessoa 58051-900, BrazilPrograma de Pós Graduação em Odontologia, Centro de Ciências da Saúde, Universidade Federal da Paraíba—UFPB, João Pessoa 58051-900, BrazilDNA methylation is the most studied epigenetic mark, and it can be altered by environmental factors. Among these factors, ultraviolet radiation (UV) is little explored within this context. While the relationship between UV radiation and DNA mutations is clear, little is known about the relationship between UV radiation and epimutations. The present study aimed to perform a literature review to determine the influence of artificial or natural (solar) UV radiation on the global and site-specific methylation profile of epidermal cells. A systematic review of the literature was carried out using the databases PubMed, Scopus, Cochrane, and Web of Science. Observational and intervention studies in cultured cells and animal or human models were included. Most studies showed a relationship between UV radiation and changes in the methylation profile, both global and site-specific. Hypermethylation and hypomethylation changes were detected, which varied according to the studied CpG site. In conclusion, UV radiation can alter the DNA methylation profile in epidermal cells derived from the skin. These data can be used as potential biomarkers for environmental exposure and skin diseases, in addition to being targets for treatments. On the other hand, UV radiation (phototherapy) can also be used as a tool to treat skin diseases. Thus, the data suggest that epigenetic homeostasis can be disrupted or restored by exposure to UV radiation according to the applied wavelength.https://www.mdpi.com/2075-4655/4/4/23DNA methylationepigeneticUV radiationsolar radiationepidermisepidermal |
| spellingShingle | Naila Francis Paulo de Oliveira Beatriz Fernandes de Souza Marina de Castro Coêlho UV Radiation and Its Relation to DNA Methylation in Epidermal Cells: A Review Epigenomes DNA methylation epigenetic UV radiation solar radiation epidermis epidermal |
| title | UV Radiation and Its Relation to DNA Methylation in Epidermal Cells: A Review |
| title_full | UV Radiation and Its Relation to DNA Methylation in Epidermal Cells: A Review |
| title_fullStr | UV Radiation and Its Relation to DNA Methylation in Epidermal Cells: A Review |
| title_full_unstemmed | UV Radiation and Its Relation to DNA Methylation in Epidermal Cells: A Review |
| title_short | UV Radiation and Its Relation to DNA Methylation in Epidermal Cells: A Review |
| title_sort | uv radiation and its relation to dna methylation in epidermal cells a review |
| topic | DNA methylation epigenetic UV radiation solar radiation epidermis epidermal |
| url | https://www.mdpi.com/2075-4655/4/4/23 |
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