MiR-30a-5p frequently downregulated in prostate cancer inhibits cell proliferation via targeting PCLAF
MicroRNAs (miRNAs) have vastly expanded our view of RNA world in intracellular signal regulating networks. Here, we functionally characterized a normally highly expressed miRNA, miR-30a-5p (MIMAT0000087), which exhibits downregulated expression profiles in prostate cancer samples. MiR-30a-5p knockdo...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2019-12-01
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| Series: | Artificial Cells, Nanomedicine, and Biotechnology |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/21691401.2018.1553783 |
| _version_ | 1817981413004148736 |
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| author | Hu Zhao Wei Zhang Xiaofeng Lai Hehuan Zhu Shenhang Zhang Weizhen Wu Shuiliang Wang Minying Tang Zhen Deng Jianming Tan |
| author_facet | Hu Zhao Wei Zhang Xiaofeng Lai Hehuan Zhu Shenhang Zhang Weizhen Wu Shuiliang Wang Minying Tang Zhen Deng Jianming Tan |
| author_sort | Hu Zhao |
| collection | DOAJ |
| description | MicroRNAs (miRNAs) have vastly expanded our view of RNA world in intracellular signal regulating networks. Here, we functionally characterized a normally highly expressed miRNA, miR-30a-5p (MIMAT0000087), which exhibits downregulated expression profiles in prostate cancer samples. MiR-30a-5p knockdown and overexpression in PC-3 cell line alters cell proliferation supporting a tumour suppressor role. We also discovered that PCLAF is the direct target of miR-30a-5p. Notably, PC-3 cell proliferation is inhibited by miR-30a-5p/PCLAF axis. miR-30a-5p represents a novel molecule of functionally important miRNAs which may shed light on the novel therapeutic targets for prostate cancer. |
| first_indexed | 2024-04-13T23:05:37Z |
| format | Article |
| id | doaj.art-e7cf2983653a46b486d5a5a3de47cf7f |
| institution | Directory Open Access Journal |
| issn | 2169-1401 2169-141X |
| language | English |
| last_indexed | 2024-04-13T23:05:37Z |
| publishDate | 2019-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Artificial Cells, Nanomedicine, and Biotechnology |
| spelling | doaj.art-e7cf2983653a46b486d5a5a3de47cf7f2022-12-22T02:25:41ZengTaylor & Francis GroupArtificial Cells, Nanomedicine, and Biotechnology2169-14012169-141X2019-12-0147127828910.1080/21691401.2018.1553783MiR-30a-5p frequently downregulated in prostate cancer inhibits cell proliferation via targeting PCLAFHu Zhao0Wei Zhang1Xiaofeng Lai2Hehuan Zhu3Shenhang Zhang4Weizhen Wu5Shuiliang Wang6Minying Tang7Zhen Deng8Jianming Tan9Fujian Provincial Key Laboratory of Transplant Biology, Fuzhou Dongfang Hospital of Xiamen University (900 Hospital of the Joint Logistics Team), Fuzhou, Fujian, P.R. ChinaDepartment of Urology, Bayi Hospital affiliated Nanjing University of Chinese Medicine, Nanjing, P. R. ChinaDepartment of Clinical Genetics and Experimental Medicine, 900 Hospital of the Joint Logistics Team, Xiamen University School of Medicine, Fuzhou, Fujian, P. R. ChinaFujian Provincial Key Laboratory of Transplant Biology, Fuzhou Dongfang Hospital of Xiamen University (900 Hospital of the Joint Logistics Team), Fuzhou, Fujian, P.R. ChinaChinaFujian Key Laboratory of Exercise Rehabilitation, College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, P. R. ChinaFujian Provincial Key Laboratory of Transplant Biology, Fuzhou Dongfang Hospital of Xiamen University (900 Hospital of the Joint Logistics Team), Fuzhou, Fujian, P.R. ChinaFujian Provincial Key Laboratory of Transplant Biology, Fuzhou Dongfang Hospital of Xiamen University (900 Hospital of the Joint Logistics Team), Fuzhou, Fujian, P.R. ChinaFujian Provincial Key Laboratory of Transplant Biology, Fuzhou Dongfang Hospital of Xiamen University (900 Hospital of the Joint Logistics Team), Fuzhou, Fujian, P.R. ChinaFujian Provincial Key Laboratory of Transplant Biology, Fuzhou Dongfang Hospital of Xiamen University (900 Hospital of the Joint Logistics Team), Fuzhou, Fujian, P.R. ChinaFujian Provincial Key Laboratory of Transplant Biology, Fuzhou Dongfang Hospital of Xiamen University (900 Hospital of the Joint Logistics Team), Fuzhou, Fujian, P.R. ChinaMicroRNAs (miRNAs) have vastly expanded our view of RNA world in intracellular signal regulating networks. Here, we functionally characterized a normally highly expressed miRNA, miR-30a-5p (MIMAT0000087), which exhibits downregulated expression profiles in prostate cancer samples. MiR-30a-5p knockdown and overexpression in PC-3 cell line alters cell proliferation supporting a tumour suppressor role. We also discovered that PCLAF is the direct target of miR-30a-5p. Notably, PC-3 cell proliferation is inhibited by miR-30a-5p/PCLAF axis. miR-30a-5p represents a novel molecule of functionally important miRNAs which may shed light on the novel therapeutic targets for prostate cancer.https://www.tandfonline.com/doi/10.1080/21691401.2018.1553783MiR-30a-5pprostate cancerPCLAFproliferation |
| spellingShingle | Hu Zhao Wei Zhang Xiaofeng Lai Hehuan Zhu Shenhang Zhang Weizhen Wu Shuiliang Wang Minying Tang Zhen Deng Jianming Tan MiR-30a-5p frequently downregulated in prostate cancer inhibits cell proliferation via targeting PCLAF Artificial Cells, Nanomedicine, and Biotechnology MiR-30a-5p prostate cancer PCLAF proliferation |
| title | MiR-30a-5p frequently downregulated in prostate cancer inhibits cell proliferation via targeting PCLAF |
| title_full | MiR-30a-5p frequently downregulated in prostate cancer inhibits cell proliferation via targeting PCLAF |
| title_fullStr | MiR-30a-5p frequently downregulated in prostate cancer inhibits cell proliferation via targeting PCLAF |
| title_full_unstemmed | MiR-30a-5p frequently downregulated in prostate cancer inhibits cell proliferation via targeting PCLAF |
| title_short | MiR-30a-5p frequently downregulated in prostate cancer inhibits cell proliferation via targeting PCLAF |
| title_sort | mir 30a 5p frequently downregulated in prostate cancer inhibits cell proliferation via targeting pclaf |
| topic | MiR-30a-5p prostate cancer PCLAF proliferation |
| url | https://www.tandfonline.com/doi/10.1080/21691401.2018.1553783 |
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