Circadian blood pressure abnormalities in patients with primary nephrotic syndrome
Background: Only a few studies have evaluated the abnormalities of ambulatory blood pressure (ABP) in patients with nephrotic syndrome (NS). Methods: The 24-h ABPs were measured in primary NS patients with acute onset of disease and analyzed in relation to the clinical variables. Results: Our subjec...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-02-01
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| Series: | Clinical and Experimental Hypertension |
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| Online Access: | http://dx.doi.org/10.1080/10641963.2016.1235179 |
| _version_ | 1797681552787767296 |
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| author | Kotaro Haruhara Nobuo Tsuboi Kentaro Koike Go Kanzaki Yusuke Okabayashi Takaya Sasaki Akira Fukui Yoichi Miyazaki Tetsuya Kawamura Makoto Ogura Takashi Yokoo |
| author_facet | Kotaro Haruhara Nobuo Tsuboi Kentaro Koike Go Kanzaki Yusuke Okabayashi Takaya Sasaki Akira Fukui Yoichi Miyazaki Tetsuya Kawamura Makoto Ogura Takashi Yokoo |
| author_sort | Kotaro Haruhara |
| collection | DOAJ |
| description | Background: Only a few studies have evaluated the abnormalities of ambulatory blood pressure (ABP) in patients with nephrotic syndrome (NS). Methods: The 24-h ABPs were measured in primary NS patients with acute onset of disease and analyzed in relation to the clinical variables. Results: Our subjects comprised 21 patients: 17 with minimal change disease and 4 with focal segmental glomerulosclerosis. Of these patients, 8 (38%) had daytime hypertension, 13 (62%) had nighttime hypertension, and 13 (62%) were non-dippers (nighttime-to-daytime ratio of ABP: NDR > 0.9). The serum sodium level was correlated with the average 24-h ABP and NDR, after adjustment for other clinical variables, such as the increase in body weight, serum albumin level, and urinary protein excretion. The data from repeated ABP measurements, before and after the achievement of remission, showed a marked decrease in the average 24-h ABP after remission. Furthermore, change in the serum sodium level was significantly correlated with the change in NDR. Conclusion: These results suggest that alteration in renal handling of sodium and water, which might be reflected in serum sodium level, is involved in the abnormality of circadian blood pressure in primary NS patients. |
| first_indexed | 2024-03-11T23:46:31Z |
| format | Article |
| id | doaj.art-e7d1f26f085247698b160f7b76378c82 |
| institution | Directory Open Access Journal |
| issn | 1064-1963 1525-6006 |
| language | English |
| last_indexed | 2024-03-11T23:46:31Z |
| publishDate | 2017-02-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Clinical and Experimental Hypertension |
| spelling | doaj.art-e7d1f26f085247698b160f7b76378c822023-09-19T09:24:45ZengTaylor & Francis GroupClinical and Experimental Hypertension1064-19631525-60062017-02-0139215515910.1080/10641963.2016.12351791235179Circadian blood pressure abnormalities in patients with primary nephrotic syndromeKotaro Haruhara0Nobuo Tsuboi1Kentaro Koike2Go Kanzaki3Yusuke Okabayashi4Takaya Sasaki5Akira Fukui6Yoichi Miyazaki7Tetsuya Kawamura8Makoto Ogura9Takashi Yokoo10The Jikei University School of MedicineThe Jikei University School of MedicineThe Jikei University School of MedicineThe Jikei University School of MedicineThe Jikei University School of MedicineThe Jikei University School of MedicineThe Jikei University School of MedicineThe Jikei University School of MedicineThe Jikei University School of MedicineThe Jikei University School of MedicineThe Jikei University School of MedicineBackground: Only a few studies have evaluated the abnormalities of ambulatory blood pressure (ABP) in patients with nephrotic syndrome (NS). Methods: The 24-h ABPs were measured in primary NS patients with acute onset of disease and analyzed in relation to the clinical variables. Results: Our subjects comprised 21 patients: 17 with minimal change disease and 4 with focal segmental glomerulosclerosis. Of these patients, 8 (38%) had daytime hypertension, 13 (62%) had nighttime hypertension, and 13 (62%) were non-dippers (nighttime-to-daytime ratio of ABP: NDR > 0.9). The serum sodium level was correlated with the average 24-h ABP and NDR, after adjustment for other clinical variables, such as the increase in body weight, serum albumin level, and urinary protein excretion. The data from repeated ABP measurements, before and after the achievement of remission, showed a marked decrease in the average 24-h ABP after remission. Furthermore, change in the serum sodium level was significantly correlated with the change in NDR. Conclusion: These results suggest that alteration in renal handling of sodium and water, which might be reflected in serum sodium level, is involved in the abnormality of circadian blood pressure in primary NS patients.http://dx.doi.org/10.1080/10641963.2016.1235179ambulatory blood pressure monitoringnephrotic syndromenocturnal hypertensionnon-dipper typerenal sodium handlingserum sodium |
| spellingShingle | Kotaro Haruhara Nobuo Tsuboi Kentaro Koike Go Kanzaki Yusuke Okabayashi Takaya Sasaki Akira Fukui Yoichi Miyazaki Tetsuya Kawamura Makoto Ogura Takashi Yokoo Circadian blood pressure abnormalities in patients with primary nephrotic syndrome Clinical and Experimental Hypertension ambulatory blood pressure monitoring nephrotic syndrome nocturnal hypertension non-dipper type renal sodium handling serum sodium |
| title | Circadian blood pressure abnormalities in patients with primary nephrotic syndrome |
| title_full | Circadian blood pressure abnormalities in patients with primary nephrotic syndrome |
| title_fullStr | Circadian blood pressure abnormalities in patients with primary nephrotic syndrome |
| title_full_unstemmed | Circadian blood pressure abnormalities in patients with primary nephrotic syndrome |
| title_short | Circadian blood pressure abnormalities in patients with primary nephrotic syndrome |
| title_sort | circadian blood pressure abnormalities in patients with primary nephrotic syndrome |
| topic | ambulatory blood pressure monitoring nephrotic syndrome nocturnal hypertension non-dipper type renal sodium handling serum sodium |
| url | http://dx.doi.org/10.1080/10641963.2016.1235179 |
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