iPSC-Derived Endothelial Cells Affect Vascular Function in a Tissue-Engineered Blood Vessel Model of Hutchinson-Gilford Progeria Syndrome
Summary: Hutchinson-Gilford progeria syndrome (HGPS) is a rare disorder caused by a point mutation in the Lamin A gene that produces the protein progerin. Progerin toxicity leads to accelerated aging and death from cardiovascular disease. To elucidate the effects of progerin on endothelial cells, we...
Main Authors: | Leigh Atchison, Nadia O. Abutaleb, Elizabeth Snyder-Mounts, Yantenew Gete, Alim Ladha, Thomas Ribar, Kan Cao, George A. Truskey |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2020-02-01
|
Series: | Stem Cell Reports |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2213671120300266 |
Similar Items
-
Lonafarnib and everolimus reduce pathology in iPSC-derived tissue engineered blood vessel model of Hutchinson-Gilford Progeria Syndrome
by: Nadia O. Abutaleb, et al.
Published: (2023-03-01) -
Impaired LEF1 Activation Accelerates iPSC-Derived Keratinocytes Differentiation in Hutchinson-Gilford Progeria Syndrome
by: Xiaojing Mao, et al.
Published: (2022-05-01) -
Hutchinson-Gilford progeria syndrome
by: Zahoor Hussain Daraz, et al.
Published: (2017-06-01) -
Hutchinson-Gilford progeria syndrome
by: Amar Singh Bhukya, et al.
Published: (2015-01-01) -
Metabolic Dysfunction in Hutchinson–Gilford Progeria Syndrome
by: Ray Kreienkamp, et al.
Published: (2020-02-01)