TLR-2 Signaling Promotes IL-17A Production in CD4+CD25+Foxp3+ Regulatory Cells during Oropharyngeal Candidiasis

TLR-2 Signaling Promotes IL-17A Production in CD4+CD25+Foxp3+ Regulatory Cells during Oropharyngeal Candidiasis

Recent studies show that CD4+CD25+Foxp3+ regulatory cells (Tregs) produce effector cytokines under inflammatory conditions. However, the direct role of microbial agents that serve as toll-like receptor (TLR) ligands in the induction of effector cytokines in Tregs is less clear. Here we show that CD4...

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Bibliographic Details
Main Authors: Natarajan Bhaskaran, Samuel Cohen, Yifan Zhang, Aaron Weinberg, Pushpa Pandiyan
Format: Article
Language:English
Published: MDPI AG 2015-03-01
Series:Pathogens
Subjects:
Treg
Foxp3
Th17
IL-17A
TLR ligands
TLR-2
Candida albicans
IBD
Online Access:http://www.mdpi.com/2076-0817/4/1/90

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