Serum klotho as a novel biomarker for metabolic syndrome: findings from a large national cohort
BackgroundMetabolic syndrome is a cluster of metabolic abnormalities that significantly increase the risk of cardiovascular disease and mortality. The identification of novel biomarkers associated with mortality in patients with metabolic syndrome could facilitate early risk stratification and targe...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1295927/full |
| _version_ | 1827330834656395264 |
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| author | Li Yuguang Yu Chang Naifei Chen Yixin Zhao Xinwei Zhang Wei Song Jin Lu Xiangliang Liu |
| author_facet | Li Yuguang Yu Chang Naifei Chen Yixin Zhao Xinwei Zhang Wei Song Jin Lu Xiangliang Liu |
| author_sort | Li Yuguang |
| collection | DOAJ |
| description | BackgroundMetabolic syndrome is a cluster of metabolic abnormalities that significantly increase the risk of cardiovascular disease and mortality. The identification of novel biomarkers associated with mortality in patients with metabolic syndrome could facilitate early risk stratification and targeted interventions.MethodsWe conducted a large prospective cohort study using data from five cycles (2009-2016) of the National Health and Nutrition Examination Survey (NHANES) database, including a total of 40,439 participants. Logistic regression analysis was used to assess the association between serum klotho protein levels and metabolic syndrome, while Cox regression analysis was employed to examine the correlation between serum klotho levels and all-cause mortality. Mortality data were updated until December 31, 2019.ResultsAfter adjusting for demographic and socioeconomic confounders, the logistic regression model demonstrated that higher serum klotho levels were significantly associated with a decreased prevalence of metabolic syndrome (OR [95% CI] Highest vs. lowest quartile: 0.84 [0.70-0.99], P=0.038). In the Cox regression model, elevated klotho levels were found to significantly reduce the risk of all-cause mortality among individuals with metabolic syndrome (HR [95% CI] Highest vs. lowest quartile: 0.68 [0.51-0.90], P=0.006).ConclusionSerum klotho levels were found to be inversely associated with the prevalence of metabolic syndrome, independent of potential confounding factors such as demographics, socioeconomic status, and lifestyle factors. Furthermore, higher klotho levels strongly indicated a lower risk of all-cause mortality in individuals with metabolic syndrome. |
| first_indexed | 2024-03-07T16:23:09Z |
| format | Article |
| id | doaj.art-e7d5dd8306574754b37efd0082ccd294 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-07T16:23:09Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-e7d5dd8306574754b37efd0082ccd2942024-03-04T04:50:01ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-03-011510.3389/fendo.2024.12959271295927Serum klotho as a novel biomarker for metabolic syndrome: findings from a large national cohortLi Yuguang0Yu Chang1Naifei Chen2Yixin Zhao3Xinwei Zhang4Wei Song5Jin Lu6Xiangliang Liu7Cancer Center, The First Hospital of Jilin University, Changchun, ChinaDepartment of Gastroenterology,The First Hospital of Jilin University, Changchun, ChinaCancer Center, The First Hospital of Jilin University, Changchun, ChinaCancer Center, The First Hospital of Jilin University, Changchun, ChinaCancer Center, The First Hospital of Jilin University, Changchun, ChinaCancer Center, The First Hospital of Jilin University, Changchun, ChinaCancer Center, The First Hospital of Jilin University, Changchun, ChinaCancer Center, The First Hospital of Jilin University, Changchun, ChinaBackgroundMetabolic syndrome is a cluster of metabolic abnormalities that significantly increase the risk of cardiovascular disease and mortality. The identification of novel biomarkers associated with mortality in patients with metabolic syndrome could facilitate early risk stratification and targeted interventions.MethodsWe conducted a large prospective cohort study using data from five cycles (2009-2016) of the National Health and Nutrition Examination Survey (NHANES) database, including a total of 40,439 participants. Logistic regression analysis was used to assess the association between serum klotho protein levels and metabolic syndrome, while Cox regression analysis was employed to examine the correlation between serum klotho levels and all-cause mortality. Mortality data were updated until December 31, 2019.ResultsAfter adjusting for demographic and socioeconomic confounders, the logistic regression model demonstrated that higher serum klotho levels were significantly associated with a decreased prevalence of metabolic syndrome (OR [95% CI] Highest vs. lowest quartile: 0.84 [0.70-0.99], P=0.038). In the Cox regression model, elevated klotho levels were found to significantly reduce the risk of all-cause mortality among individuals with metabolic syndrome (HR [95% CI] Highest vs. lowest quartile: 0.68 [0.51-0.90], P=0.006).ConclusionSerum klotho levels were found to be inversely associated with the prevalence of metabolic syndrome, independent of potential confounding factors such as demographics, socioeconomic status, and lifestyle factors. Furthermore, higher klotho levels strongly indicated a lower risk of all-cause mortality in individuals with metabolic syndrome.https://www.frontiersin.org/articles/10.3389/fendo.2024.1295927/fullmetabolic syndromeklothomortalitybiomarkersNHANES |
| spellingShingle | Li Yuguang Yu Chang Naifei Chen Yixin Zhao Xinwei Zhang Wei Song Jin Lu Xiangliang Liu Serum klotho as a novel biomarker for metabolic syndrome: findings from a large national cohort Frontiers in Endocrinology metabolic syndrome klotho mortality biomarkers NHANES |
| title | Serum klotho as a novel biomarker for metabolic syndrome: findings from a large national cohort |
| title_full | Serum klotho as a novel biomarker for metabolic syndrome: findings from a large national cohort |
| title_fullStr | Serum klotho as a novel biomarker for metabolic syndrome: findings from a large national cohort |
| title_full_unstemmed | Serum klotho as a novel biomarker for metabolic syndrome: findings from a large national cohort |
| title_short | Serum klotho as a novel biomarker for metabolic syndrome: findings from a large national cohort |
| title_sort | serum klotho as a novel biomarker for metabolic syndrome findings from a large national cohort |
| topic | metabolic syndrome klotho mortality biomarkers NHANES |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1295927/full |
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