Surface co-expression of two different PfEMP1 antigens on single plasmodium falciparum-infected erythrocytes facilitates binding to ICAM1 and PECAM1.

Surface co-expression of two different PfEMP1 antigens on single plasmodium falciparum-infected erythrocytes facilitates binding to ICAM1 and PECAM1.

The Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) antigens play a major role in cytoadhesion of infected erythrocytes (IE), antigenic variation, and immunity to malaria. The current consensus on control of variant surface antigen expression is that only one PfEMP1 encoded by one var...

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Bibliographic Details
Main Authors: Louise Joergensen, Dominique C Bengtsson, Anja Bengtsson, Elena Ronander, Sanne S Berger, Louise Turner, Michael B Dalgaard, Gerald K K Cham, Michala E Victor, Thomas Lavstsen, Thor G Theander, David E Arnot, Anja T R Jensen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-09-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2932717?pdf=render

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