Induced Cardiomyocyte Proliferation: A Promising Approach to Cure Heart Failure
Unlike some lower vertebrates which can completely regenerate their heart, the human heart is a terminally differentiated organ. Cardiomyocytes lost during cardiac injury and heart failure cannot be replaced due to their limited proliferative capacity. Therefore, cardiac injury generally leads to pr...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/14/7720 |
| _version_ | 1797526963690143744 |
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| author | Abou Bakr M. Salama Ahmad Gebreil Tamer M. A. Mohamed Riham R. E. Abouleisa |
| author_facet | Abou Bakr M. Salama Ahmad Gebreil Tamer M. A. Mohamed Riham R. E. Abouleisa |
| author_sort | Abou Bakr M. Salama |
| collection | DOAJ |
| description | Unlike some lower vertebrates which can completely regenerate their heart, the human heart is a terminally differentiated organ. Cardiomyocytes lost during cardiac injury and heart failure cannot be replaced due to their limited proliferative capacity. Therefore, cardiac injury generally leads to progressive failure. Here, we summarize the latest progress in research on methods to induce cardiomyocyte cell cycle entry and heart repair through the alteration of cardiomyocyte plasticity, which is emerging as an effective strategy to compensate for the loss of functional cardiomyocytes and improve the impaired heart functions. |
| first_indexed | 2024-03-10T09:36:47Z |
| format | Article |
| id | doaj.art-e7d903bd63ba4afa897e5fbeb6c92b17 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T09:36:47Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-e7d903bd63ba4afa897e5fbeb6c92b172023-11-22T04:03:08ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-07-012214772010.3390/ijms22147720Induced Cardiomyocyte Proliferation: A Promising Approach to Cure Heart FailureAbou Bakr M. Salama0Ahmad Gebreil1Tamer M. A. Mohamed2Riham R. E. Abouleisa3Department of Medicine, Division of Cardiovascular Medicine, Institute of Molecular Cardiology, University of Louisville, 580 S. Preston St., Rm 122, Louisville, KY 40202, USADepartment of Medicine, Division of Cardiovascular Medicine, Institute of Molecular Cardiology, University of Louisville, 580 S. Preston St., Rm 122, Louisville, KY 40202, USADepartment of Medicine, Division of Cardiovascular Medicine, Institute of Molecular Cardiology, University of Louisville, 580 S. Preston St., Rm 122, Louisville, KY 40202, USADepartment of Medicine, Division of Cardiovascular Medicine, Institute of Molecular Cardiology, University of Louisville, 580 S. Preston St., Rm 122, Louisville, KY 40202, USAUnlike some lower vertebrates which can completely regenerate their heart, the human heart is a terminally differentiated organ. Cardiomyocytes lost during cardiac injury and heart failure cannot be replaced due to their limited proliferative capacity. Therefore, cardiac injury generally leads to progressive failure. Here, we summarize the latest progress in research on methods to induce cardiomyocyte cell cycle entry and heart repair through the alteration of cardiomyocyte plasticity, which is emerging as an effective strategy to compensate for the loss of functional cardiomyocytes and improve the impaired heart functions.https://www.mdpi.com/1422-0067/22/14/7720cardiomyocyte proliferationcardiac regenerationcell cycle |
| spellingShingle | Abou Bakr M. Salama Ahmad Gebreil Tamer M. A. Mohamed Riham R. E. Abouleisa Induced Cardiomyocyte Proliferation: A Promising Approach to Cure Heart Failure International Journal of Molecular Sciences cardiomyocyte proliferation cardiac regeneration cell cycle |
| title | Induced Cardiomyocyte Proliferation: A Promising Approach to Cure Heart Failure |
| title_full | Induced Cardiomyocyte Proliferation: A Promising Approach to Cure Heart Failure |
| title_fullStr | Induced Cardiomyocyte Proliferation: A Promising Approach to Cure Heart Failure |
| title_full_unstemmed | Induced Cardiomyocyte Proliferation: A Promising Approach to Cure Heart Failure |
| title_short | Induced Cardiomyocyte Proliferation: A Promising Approach to Cure Heart Failure |
| title_sort | induced cardiomyocyte proliferation a promising approach to cure heart failure |
| topic | cardiomyocyte proliferation cardiac regeneration cell cycle |
| url | https://www.mdpi.com/1422-0067/22/14/7720 |
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