The effects of dextromethorphan on the outcome of percutaneous coronary intervention with bare-metal stent implantation
Background: In the era of drug-eluting stents, although bare-metal stent (BMS) remains an option for percutaneous coronary intervention (PCI), restenosis remains the Achilles' heel of BMS implantation. A recent study demonstrated several pleiotropic anti-inflammatory effects of dextromethorphan...
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| Format: | Article |
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Wolters Kluwer Medknow Publications
2018-01-01
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| Series: | Journal of Medical Sciences |
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| Online Access: | http://www.jmedscindmc.com/article.asp?issn=1011-4564;year=2018;volume=38;issue=2;spage=62;epage=66;aulast=Liu |
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| author | Wen-Cheng Liu Min-Chien Tsai Cheng-Chung Cheng Sy-Jou Chen Han-Bin Huang Jun-Ting Liou Wei-Shiang Lin Shu-Meng Cheng Shih-Ping Yang Tien-Ping Tsao |
| author_facet | Wen-Cheng Liu Min-Chien Tsai Cheng-Chung Cheng Sy-Jou Chen Han-Bin Huang Jun-Ting Liou Wei-Shiang Lin Shu-Meng Cheng Shih-Ping Yang Tien-Ping Tsao |
| author_sort | Wen-Cheng Liu |
| collection | DOAJ |
| description | Background: In the era of drug-eluting stents, although bare-metal stent (BMS) remains an option for percutaneous coronary intervention (PCI), restenosis remains the Achilles' heel of BMS implantation. A recent study demonstrated several pleiotropic anti-inflammatory effects of dextromethorphan (DXM). This study aims to evaluate the effects of DXM on the outcome of PCI with BMS implantation.Methods: In this prospective, double-blind, randomized trial, we enrolled 55 patients who underwent PCI with BMS implantation from May 2006 to February 2009. The patients were divided into DXM (60 mg once daily) and placebo groups. We compared mortality rates, myocardial infarction (MI), target lesion revascularization (TLR), restenosis, stent thrombosis, and plasma levels of high-sensitivity C-reactive protein (hs-CRP) with repeated coronary angiography 6 months after the initial procedure.Results: During the 6-month follow-up period, no events of death, MI and stent thrombosis were reported in both groups. The TLR rate was 16.7% in patients receiving DXM compared to 24% receiving a placebo (P = 0.521). The restenosis rate was 30% in patients receiving DXM as compared to 40% receiving the placebo (P = 0.571). Although nonsignificant, the percentage of hs-CRP elevation was lower in the DXM group (20%) compared to the placebo group 32%; P = 0.363).Conclusions: DXM is safe to use in patients who underwent PCI. Although DXM therapy following BMS implantation did not significantly reduce the TLR and restenosis rates, it implied a trend toward a lower TLR and restenosis and reduced inflammation in the DXM group compared to the placebo group. Nonetheless, further extensive studies are warranted to elucidate the anti-restenosis effects of DXM. |
| first_indexed | 2024-12-23T05:12:03Z |
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| institution | Directory Open Access Journal |
| issn | 1011-4564 |
| language | English |
| last_indexed | 2024-12-23T05:12:03Z |
| publishDate | 2018-01-01 |
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| series | Journal of Medical Sciences |
| spelling | doaj.art-e7d9fb5577bb4fe08c5e8c0e1ae146042022-12-21T17:58:57ZengWolters Kluwer Medknow PublicationsJournal of Medical Sciences1011-45642018-01-01382626610.4103/jmedsci.jmedsci_145_17The effects of dextromethorphan on the outcome of percutaneous coronary intervention with bare-metal stent implantationWen-Cheng LiuMin-Chien TsaiCheng-Chung ChengSy-Jou ChenHan-Bin HuangJun-Ting LiouWei-Shiang LinShu-Meng ChengShih-Ping YangTien-Ping TsaoBackground: In the era of drug-eluting stents, although bare-metal stent (BMS) remains an option for percutaneous coronary intervention (PCI), restenosis remains the Achilles' heel of BMS implantation. A recent study demonstrated several pleiotropic anti-inflammatory effects of dextromethorphan (DXM). This study aims to evaluate the effects of DXM on the outcome of PCI with BMS implantation.Methods: In this prospective, double-blind, randomized trial, we enrolled 55 patients who underwent PCI with BMS implantation from May 2006 to February 2009. The patients were divided into DXM (60 mg once daily) and placebo groups. We compared mortality rates, myocardial infarction (MI), target lesion revascularization (TLR), restenosis, stent thrombosis, and plasma levels of high-sensitivity C-reactive protein (hs-CRP) with repeated coronary angiography 6 months after the initial procedure.Results: During the 6-month follow-up period, no events of death, MI and stent thrombosis were reported in both groups. The TLR rate was 16.7% in patients receiving DXM compared to 24% receiving a placebo (P = 0.521). The restenosis rate was 30% in patients receiving DXM as compared to 40% receiving the placebo (P = 0.571). Although nonsignificant, the percentage of hs-CRP elevation was lower in the DXM group (20%) compared to the placebo group 32%; P = 0.363).Conclusions: DXM is safe to use in patients who underwent PCI. Although DXM therapy following BMS implantation did not significantly reduce the TLR and restenosis rates, it implied a trend toward a lower TLR and restenosis and reduced inflammation in the DXM group compared to the placebo group. Nonetheless, further extensive studies are warranted to elucidate the anti-restenosis effects of DXM.http://www.jmedscindmc.com/article.asp?issn=1011-4564;year=2018;volume=38;issue=2;spage=62;epage=66;aulast=LiuDextromethorphanrestenosisbare-metal stent implantation |
| spellingShingle | Wen-Cheng Liu Min-Chien Tsai Cheng-Chung Cheng Sy-Jou Chen Han-Bin Huang Jun-Ting Liou Wei-Shiang Lin Shu-Meng Cheng Shih-Ping Yang Tien-Ping Tsao The effects of dextromethorphan on the outcome of percutaneous coronary intervention with bare-metal stent implantation Journal of Medical Sciences Dextromethorphan restenosis bare-metal stent implantation |
| title | The effects of dextromethorphan on the outcome of percutaneous coronary intervention with bare-metal stent implantation |
| title_full | The effects of dextromethorphan on the outcome of percutaneous coronary intervention with bare-metal stent implantation |
| title_fullStr | The effects of dextromethorphan on the outcome of percutaneous coronary intervention with bare-metal stent implantation |
| title_full_unstemmed | The effects of dextromethorphan on the outcome of percutaneous coronary intervention with bare-metal stent implantation |
| title_short | The effects of dextromethorphan on the outcome of percutaneous coronary intervention with bare-metal stent implantation |
| title_sort | effects of dextromethorphan on the outcome of percutaneous coronary intervention with bare metal stent implantation |
| topic | Dextromethorphan restenosis bare-metal stent implantation |
| url | http://www.jmedscindmc.com/article.asp?issn=1011-4564;year=2018;volume=38;issue=2;spage=62;epage=66;aulast=Liu |
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