Characterization and Reliability of [18F]2FNQ1P in Cynomolgus Monkeys as a PET Radiotracer for Serotonin 5-HT6 Receptors

Characterization and Reliability of [18F]2FNQ1P in Cynomolgus Monkeys as a PET Radiotracer for Serotonin 5-HT6 Receptors

Brain serotonin-6 receptor (5-HT6R) is the one of the most recently identified serotonin receptors. Accumulating evidence suggests that it is a potent therapeutic target for psychiatric and neurological diseases. Since [18F]2FNQ1P was recently proposed as the first fluorinated positron emission tomo...

Full description

Bibliographic Details
Main Authors: Véronique Sgambato-Faure, Thierry Billard, Elise Météreau, Sandra Duperrier, Sylvain Fieux, Nicolas Costes, Léon Tremblay, Luc Zimmer
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-07-01
Series:Frontiers in Pharmacology
Subjects:
PET imaging
serotonin
5-HT6 receptor
striatum
non-human primate
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00471/full

Similar Items

Similar Items