Alterations in the gut microbiome and its metabolites are associated with the immune response to mucosal immunization with Lactiplantibacillus plantarum-displaying recombinant SARS-CoV-2 spike epitopes in mice

Alterations in the gut microbiome and its metabolites are associated with the immune response to mucosal immunization with Lactiplantibacillus plantarum-displaying recombinant SARS-CoV-2 spike epitopes in mice

Lactic acid bacteria (LAB) expressing foreign antigens have great potential as mucosal vaccines. Our previous study reported that recombinant Lactiplantibacillus plantarum SK156 displaying SARS-CoV-2 spike S1 epitopes elicited humoral and cell-mediated immune responses in mice. Here, we further exam...

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Bibliographic Details
Main Authors: In-Chan Hwang, Robie Vasquez, Ji Hoon Song, Lars Engstrand, Valerie Diane Valeriano, Dae-Kyung Kang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
gut microbiome
mucosal vaccine
SARS-CoV-2
COVID-19
lactic acid bacteria
butyrate
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2023.1242681/full

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