Hydrophilic nanoparticles that kill bacteria while sparing mammalian cells reveal the antibiotic role of nanostructures
Developing antibacterial agents which don’t have cytotoxic effects against mammalian cells is of interest for biomedical applications. Here, the authors explore how attaching inert polymer brushes to different sized nanoparticles can result in toxicity to bacteria but not to mammalian cells in a siz...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-27193-9 |
| _version_ | 1818753510893682688 |
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| author | Yunjiang Jiang Wan Zheng Keith Tran Elizabeth Kamilar Jitender Bariwal Hairong Ma Hongjun Liang |
| author_facet | Yunjiang Jiang Wan Zheng Keith Tran Elizabeth Kamilar Jitender Bariwal Hairong Ma Hongjun Liang |
| author_sort | Yunjiang Jiang |
| collection | DOAJ |
| description | Developing antibacterial agents which don’t have cytotoxic effects against mammalian cells is of interest for biomedical applications. Here, the authors explore how attaching inert polymer brushes to different sized nanoparticles can result in toxicity to bacteria but not to mammalian cells in a size dependent manner. |
| first_indexed | 2024-12-18T05:08:31Z |
| format | Article |
| id | doaj.art-e7deb133ee7346a3824826ae7496a308 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-18T05:08:31Z |
| publishDate | 2022-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-e7deb133ee7346a3824826ae7496a3082022-12-21T21:19:57ZengNature PortfolioNature Communications2041-17232022-01-0113111710.1038/s41467-021-27193-9Hydrophilic nanoparticles that kill bacteria while sparing mammalian cells reveal the antibiotic role of nanostructuresYunjiang Jiang0Wan Zheng1Keith Tran2Elizabeth Kamilar3Jitender Bariwal4Hairong Ma5Hongjun Liang6Department of Cell Physiology & Molecular Biophysics, Center for Membrane Protein Research, School of Medicine, Texas Tech University Health Sciences CenterDepartment of Cell Physiology & Molecular Biophysics, Center for Membrane Protein Research, School of Medicine, Texas Tech University Health Sciences CenterDepartment of Cell Physiology & Molecular Biophysics, Center for Membrane Protein Research, School of Medicine, Texas Tech University Health Sciences CenterDepartment of Cell Physiology & Molecular Biophysics, Center for Membrane Protein Research, School of Medicine, Texas Tech University Health Sciences CenterDepartment of Cell Physiology & Molecular Biophysics, Center for Membrane Protein Research, School of Medicine, Texas Tech University Health Sciences CenterDepartment of Cell Physiology & Molecular Biophysics, Center for Membrane Protein Research, School of Medicine, Texas Tech University Health Sciences CenterDepartment of Cell Physiology & Molecular Biophysics, Center for Membrane Protein Research, School of Medicine, Texas Tech University Health Sciences CenterDeveloping antibacterial agents which don’t have cytotoxic effects against mammalian cells is of interest for biomedical applications. Here, the authors explore how attaching inert polymer brushes to different sized nanoparticles can result in toxicity to bacteria but not to mammalian cells in a size dependent manner.https://doi.org/10.1038/s41467-021-27193-9 |
| spellingShingle | Yunjiang Jiang Wan Zheng Keith Tran Elizabeth Kamilar Jitender Bariwal Hairong Ma Hongjun Liang Hydrophilic nanoparticles that kill bacteria while sparing mammalian cells reveal the antibiotic role of nanostructures Nature Communications |
| title | Hydrophilic nanoparticles that kill bacteria while sparing mammalian cells reveal the antibiotic role of nanostructures |
| title_full | Hydrophilic nanoparticles that kill bacteria while sparing mammalian cells reveal the antibiotic role of nanostructures |
| title_fullStr | Hydrophilic nanoparticles that kill bacteria while sparing mammalian cells reveal the antibiotic role of nanostructures |
| title_full_unstemmed | Hydrophilic nanoparticles that kill bacteria while sparing mammalian cells reveal the antibiotic role of nanostructures |
| title_short | Hydrophilic nanoparticles that kill bacteria while sparing mammalian cells reveal the antibiotic role of nanostructures |
| title_sort | hydrophilic nanoparticles that kill bacteria while sparing mammalian cells reveal the antibiotic role of nanostructures |
| url | https://doi.org/10.1038/s41467-021-27193-9 |
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