Control of spinal motor neuron terminal differentiation through sustained Hoxc8 gene activity

Control of spinal motor neuron terminal differentiation through sustained Hoxc8 gene activity

Spinal motor neurons (MNs) constitute cellular substrates for several movement disorders. Although their early development has received much attention, how spinal MNs become and remain terminally differentiated is poorly understood. Here, we determined the transcriptome of mouse MNs located at the b...

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Bibliographic Details
Main Authors: Catarina Catela, Yihan Chen, Yifei Weng, Kailong Wen, Paschalis Kratsios
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-03-01
Series:eLife
Subjects:
neuronal differentiation
motor neurons
transcription factors
Hoxc8
Online Access:https://elifesciences.org/articles/70766

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