Aerobic exercise and unripe grape extract as antioxidant do not protect the kidney against cisplatin induced nephrotoxicity
Background: Nephrotoxicity is the cisplatin therapy side effect due to stress oxidative formation and lack of antioxidants. Objectives: The role of aerobic exercise and three different doses of unripe grape extract as an antioxidant on cisplatin-induced nephrotoxicity were studied Materials and Meth...
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| Format: | Article |
| Language: | English |
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Society of Diabetic Nephropathy Prevention
2019-01-01
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| Series: | Journal of Nephropathology |
| Subjects: | |
| Online Access: | https://nephropathol.com/PDF/jnp-8-04.pdf |
| _version_ | 1827948655589457920 |
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| author | Sayyedehnikta Kasae Saeid Keshavarz Bahar Mazaheri Behzad Zolfaghari Ardeshir Talebi Mehdi Nematbakhsh |
| author_facet | Sayyedehnikta Kasae Saeid Keshavarz Bahar Mazaheri Behzad Zolfaghari Ardeshir Talebi Mehdi Nematbakhsh |
| author_sort | Sayyedehnikta Kasae |
| collection | DOAJ |
| description | Background: Nephrotoxicity is the cisplatin therapy side effect due to stress oxidative formation and lack of antioxidants. Objectives: The role of aerobic exercise and three different doses of unripe grape extract as an antioxidant on cisplatin-induced nephrotoxicity were studied Materials and Method: Seventy male Wistar rats were randomly divided into groups of control, cisplatin (2.5 mg/kg/d for 7 days), aerobic exercise + cisplatin and unripe grape extract and also aerobic exercise + unripe grape extract. Aerobic exercise was administered in period of 7 weeks (5 days/week, 1 h/d), and unripe grape extract was used in three different doses of 20, 100, 200 mg/ kg/d for period of 7 weeks. Results: Cisplatin elevated the serum levels of blood urea nitrogen (BUN), creatinine and malondialdehyde (MDA), and also kidney weight and kidney tissue damage score and decreased body weight and the kidney tissue levels of nitrite significantly (P<0.05), but aerobic exercise or unripe grape extract did not alter the parameters toward normal levels. Conclusions: Based on these findings, aerobic exercise and antioxidant such as unripe grape extract may not protect the kidney against cisplatin-induced nephrotoxicity during anti-cancer therapy |
| first_indexed | 2024-04-09T12:57:38Z |
| format | Article |
| id | doaj.art-e7e3150be65040ee9d99cae2a6f84463 |
| institution | Directory Open Access Journal |
| issn | 2251-8363 2251-8819 |
| language | English |
| last_indexed | 2024-04-09T12:57:38Z |
| publishDate | 2019-01-01 |
| publisher | Society of Diabetic Nephropathy Prevention |
| record_format | Article |
| series | Journal of Nephropathology |
| spelling | doaj.art-e7e3150be65040ee9d99cae2a6f844632023-05-13T11:28:40ZengSociety of Diabetic Nephropathy PreventionJournal of Nephropathology2251-83632251-88192019-01-0181e04e0410.15171/jnp.2019.04jnp-20181213093252Aerobic exercise and unripe grape extract as antioxidant do not protect the kidney against cisplatin induced nephrotoxicitySayyedehnikta Kasae0Saeid Keshavarz1Bahar Mazaheri2Behzad Zolfaghari3Ardeshir Talebi4Mehdi Nematbakhsh5Department of Physical Education and Sport Sciences, Najaf-Abad Branch, Islamic Azad University, Najaf-Abad, Isfahan, IranSport Medicine Research Center, Najaf-Abad Branch, Islamic Azad University, Najaf-Abad, Isfahan, IranWater and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Pharmacognosy, Isfahan University of Medical Sciences, Isfahan, IranWater and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, IranWater and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, IranBackground: Nephrotoxicity is the cisplatin therapy side effect due to stress oxidative formation and lack of antioxidants. Objectives: The role of aerobic exercise and three different doses of unripe grape extract as an antioxidant on cisplatin-induced nephrotoxicity were studied Materials and Method: Seventy male Wistar rats were randomly divided into groups of control, cisplatin (2.5 mg/kg/d for 7 days), aerobic exercise + cisplatin and unripe grape extract and also aerobic exercise + unripe grape extract. Aerobic exercise was administered in period of 7 weeks (5 days/week, 1 h/d), and unripe grape extract was used in three different doses of 20, 100, 200 mg/ kg/d for period of 7 weeks. Results: Cisplatin elevated the serum levels of blood urea nitrogen (BUN), creatinine and malondialdehyde (MDA), and also kidney weight and kidney tissue damage score and decreased body weight and the kidney tissue levels of nitrite significantly (P<0.05), but aerobic exercise or unripe grape extract did not alter the parameters toward normal levels. Conclusions: Based on these findings, aerobic exercise and antioxidant such as unripe grape extract may not protect the kidney against cisplatin-induced nephrotoxicity during anti-cancer therapyhttps://nephropathol.com/PDF/jnp-8-04.pdfcisplatinaerobic exerciseunripe grape extract |
| spellingShingle | Sayyedehnikta Kasae Saeid Keshavarz Bahar Mazaheri Behzad Zolfaghari Ardeshir Talebi Mehdi Nematbakhsh Aerobic exercise and unripe grape extract as antioxidant do not protect the kidney against cisplatin induced nephrotoxicity Journal of Nephropathology cisplatin aerobic exercise unripe grape extract |
| title | Aerobic exercise and unripe grape extract as antioxidant do not protect the kidney against cisplatin induced nephrotoxicity |
| title_full | Aerobic exercise and unripe grape extract as antioxidant do not protect the kidney against cisplatin induced nephrotoxicity |
| title_fullStr | Aerobic exercise and unripe grape extract as antioxidant do not protect the kidney against cisplatin induced nephrotoxicity |
| title_full_unstemmed | Aerobic exercise and unripe grape extract as antioxidant do not protect the kidney against cisplatin induced nephrotoxicity |
| title_short | Aerobic exercise and unripe grape extract as antioxidant do not protect the kidney against cisplatin induced nephrotoxicity |
| title_sort | aerobic exercise and unripe grape extract as antioxidant do not protect the kidney against cisplatin induced nephrotoxicity |
| topic | cisplatin aerobic exercise unripe grape extract |
| url | https://nephropathol.com/PDF/jnp-8-04.pdf |
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