Powder Mixture for the Production of Microporous Ceramics Based on Hydroxyapatite
Powder mixtures with a given molar ratio of Ca/P = 1.67 were prepared under mechanical activation conditions from hydroxyapatite powder Ca<sub>10</sub>(PO<sub>4</sub>)<sub>6</sub>(OH)<sub>2</sub> and a 1M aqueous solution of oxalic acid H<sub>2&l...
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| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Ceramics |
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| Online Access: | https://www.mdpi.com/2571-6131/5/1/10 |
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| author | Tatiana Safronova Stepan Chichulin Tatiana Shatalova Yaroslav Filippov |
| author_facet | Tatiana Safronova Stepan Chichulin Tatiana Shatalova Yaroslav Filippov |
| author_sort | Tatiana Safronova |
| collection | DOAJ |
| description | Powder mixtures with a given molar ratio of Ca/P = 1.67 were prepared under mechanical activation conditions from hydroxyapatite powder Ca<sub>10</sub>(PO<sub>4</sub>)<sub>6</sub>(OH)<sub>2</sub> and a 1M aqueous solution of oxalic acid H<sub>2</sub>C<sub>2</sub>O<sub>4</sub> at a molar ratio of Ca<sub>10</sub>(PO<sub>4</sub>)<sub>6</sub>(OH)<sub>2</sub>/H<sub>2</sub>C<sub>2</sub>O<sub>4</sub> = 1:4. The phase composition of obtained powder mixture included brushite (calcium hydrophosphate dihydrate) CaHPO<sub>4</sub>·2H<sub>2</sub>O, calcium oxalate monohydrate CaC<sub>2</sub>O<sub>4</sub>·H<sub>2</sub>O in form of whewellite and weddellite, and some quantity of quasi-amorphous phase. This powder mixture was used to produce microporous monophase ceramics based on hydroxyapatite Ca<sub>10</sub>(PO<sub>4</sub>)<sub>6</sub>(OH)<sub>2</sub> with apparent density of 1.25 g/cm<sup>3</sup> after firing at 1200 °C. Microporosity of sintered ceramics was formed due to the presence of particles with plate-like morphology, restraining shrinkage during sintering. Microporous ceramics based on hydroxyapatite Ca<sub>10</sub>(PO<sub>4</sub>)<sub>6</sub>(OH)<sub>2</sub> with the roughness of the surface as a consequence of the created microporosity can be recommended as a biocompatible material for bone defects treatment and as a substrate for bone cell cultivation. |
| first_indexed | 2024-03-09T20:01:25Z |
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| id | doaj.art-e7e4eeec110b4b748065a0f744b2a53a |
| institution | Directory Open Access Journal |
| issn | 2571-6131 |
| language | English |
| last_indexed | 2024-03-09T20:01:25Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Ceramics |
| spelling | doaj.art-e7e4eeec110b4b748065a0f744b2a53a2023-11-24T00:45:26ZengMDPI AGCeramics2571-61312022-02-015110811910.3390/ceramics5010010Powder Mixture for the Production of Microporous Ceramics Based on HydroxyapatiteTatiana Safronova0Stepan Chichulin1Tatiana Shatalova2Yaroslav Filippov3Department of Chemistry, Lomonosov Moscow State University, Building, 3, Leninskie Gory, 1, 119991 Moscow, RussiaDepartment of Chemistry, Lomonosov Moscow State University, Building, 3, Leninskie Gory, 1, 119991 Moscow, RussiaDepartment of Chemistry, Lomonosov Moscow State University, Building, 3, Leninskie Gory, 1, 119991 Moscow, RussiaDepartment of Materials Science, Lomonosov Moscow State University, Building, 73, Leninskie Gory, 1, 119991 Moscow, RussiaPowder mixtures with a given molar ratio of Ca/P = 1.67 were prepared under mechanical activation conditions from hydroxyapatite powder Ca<sub>10</sub>(PO<sub>4</sub>)<sub>6</sub>(OH)<sub>2</sub> and a 1M aqueous solution of oxalic acid H<sub>2</sub>C<sub>2</sub>O<sub>4</sub> at a molar ratio of Ca<sub>10</sub>(PO<sub>4</sub>)<sub>6</sub>(OH)<sub>2</sub>/H<sub>2</sub>C<sub>2</sub>O<sub>4</sub> = 1:4. The phase composition of obtained powder mixture included brushite (calcium hydrophosphate dihydrate) CaHPO<sub>4</sub>·2H<sub>2</sub>O, calcium oxalate monohydrate CaC<sub>2</sub>O<sub>4</sub>·H<sub>2</sub>O in form of whewellite and weddellite, and some quantity of quasi-amorphous phase. This powder mixture was used to produce microporous monophase ceramics based on hydroxyapatite Ca<sub>10</sub>(PO<sub>4</sub>)<sub>6</sub>(OH)<sub>2</sub> with apparent density of 1.25 g/cm<sup>3</sup> after firing at 1200 °C. Microporosity of sintered ceramics was formed due to the presence of particles with plate-like morphology, restraining shrinkage during sintering. Microporous ceramics based on hydroxyapatite Ca<sub>10</sub>(PO<sub>4</sub>)<sub>6</sub>(OH)<sub>2</sub> with the roughness of the surface as a consequence of the created microporosity can be recommended as a biocompatible material for bone defects treatment and as a substrate for bone cell cultivation.https://www.mdpi.com/2571-6131/5/1/10hydroxyapatiteoxalic acidpowderwhewelliteweddellitecalcium oxalate monohydrate |
| spellingShingle | Tatiana Safronova Stepan Chichulin Tatiana Shatalova Yaroslav Filippov Powder Mixture for the Production of Microporous Ceramics Based on Hydroxyapatite Ceramics hydroxyapatite oxalic acid powder whewellite weddellite calcium oxalate monohydrate |
| title | Powder Mixture for the Production of Microporous Ceramics Based on Hydroxyapatite |
| title_full | Powder Mixture for the Production of Microporous Ceramics Based on Hydroxyapatite |
| title_fullStr | Powder Mixture for the Production of Microporous Ceramics Based on Hydroxyapatite |
| title_full_unstemmed | Powder Mixture for the Production of Microporous Ceramics Based on Hydroxyapatite |
| title_short | Powder Mixture for the Production of Microporous Ceramics Based on Hydroxyapatite |
| title_sort | powder mixture for the production of microporous ceramics based on hydroxyapatite |
| topic | hydroxyapatite oxalic acid powder whewellite weddellite calcium oxalate monohydrate |
| url | https://www.mdpi.com/2571-6131/5/1/10 |
| work_keys_str_mv | AT tatianasafronova powdermixturefortheproductionofmicroporousceramicsbasedonhydroxyapatite AT stepanchichulin powdermixturefortheproductionofmicroporousceramicsbasedonhydroxyapatite AT tatianashatalova powdermixturefortheproductionofmicroporousceramicsbasedonhydroxyapatite AT yaroslavfilippov powdermixturefortheproductionofmicroporousceramicsbasedonhydroxyapatite |