Early-cleavage is a reliable predictor for embryo implantation in the GnRH agonist protocols but not in the GnRH antagonist protocols
<p>Abstract</p> <p>Background</p> <p>To test if early-cleavage was a strong predictor of pregnancy in patients receiving either a GnRH agonist long protocol or a GnRH antagonist protocol for in-vitro fertilization treatment (IVF) and intracytoplasmic sperm injection (IC...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2009-03-01
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| Series: | Reproductive Biology and Endocrinology |
| Online Access: | http://www.rbej.com/content/7/1/20 |
| _version_ | 1818567097629802496 |
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| author | Hwu Yuh-Ming Yang Wen-Jui Lee Robert Li Sheng-Hsiang Fleming Steven |
| author_facet | Hwu Yuh-Ming Yang Wen-Jui Lee Robert Li Sheng-Hsiang Fleming Steven |
| author_sort | Hwu Yuh-Ming |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>To test if early-cleavage was a strong predictor of pregnancy in patients receiving either a GnRH agonist long protocol or a GnRH antagonist protocol for in-vitro fertilization treatment (IVF) and intracytoplasmic sperm injection (ICSI).</p> <p>Methods</p> <p>This retrospective study included 534 patients undergoing a fresh cycle of oocyte retrieval and the day-3 embryo transfer (from 22 to 46 years old). Of the 534 patients treated, 331 received a GnRH agonist long stimulation protocol (GnRH agonist group) for ovarian stimulation and 203 patients received a GnRH antagonist protocol (GnRH antagonist group). In each group, patients who had at least one early-cleavage embryo transferred were designated as the 'early-cleavage' subgroup. Patients who had no early-cleavage embryos transferred were designated as the 'late-cleavage' subgroup.</p> <p>Results</p> <p>The early cleavage rate was significantly lower in the GnRH antagonist group compared with that in the GnRH agonist group (IVF cycles: 34% versus 20%; ICSI cycles: 50% versus 37.8%, respectively, P < 0.0001). In the GnRH agonist group, the pregnancy rates were significantly higher in the early-cleavage subgroup than those in the late-cleavage subgroup (53.7% vs 33.9%, <it>P </it>< 0.0001). In the GnRH antagonist group, the pregnancy rates were not significantly different between the early-cleavage and late-cleavage subgroups (45.9% vs 43.8%, P > 0.05).</p> <p>Conclusion</p> <p>Early cleavage of zygote is not a reliable predictor for embryo implantation potential in using the GnRH antagonist protocol. Furthermore, the implantation rates between the GnRH agonist and GnRH antagonist groups were comparable.</p> |
| first_indexed | 2024-12-14T06:19:06Z |
| format | Article |
| id | doaj.art-e7ebb92a79604f318e10cf77a0efcf66 |
| institution | Directory Open Access Journal |
| issn | 1477-7827 |
| language | English |
| last_indexed | 2024-12-14T06:19:06Z |
| publishDate | 2009-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Reproductive Biology and Endocrinology |
| spelling | doaj.art-e7ebb92a79604f318e10cf77a0efcf662022-12-21T23:13:55ZengBMCReproductive Biology and Endocrinology1477-78272009-03-01712010.1186/1477-7827-7-20Early-cleavage is a reliable predictor for embryo implantation in the GnRH agonist protocols but not in the GnRH antagonist protocolsHwu Yuh-MingYang Wen-JuiLee RobertLi Sheng-HsiangFleming Steven<p>Abstract</p> <p>Background</p> <p>To test if early-cleavage was a strong predictor of pregnancy in patients receiving either a GnRH agonist long protocol or a GnRH antagonist protocol for in-vitro fertilization treatment (IVF) and intracytoplasmic sperm injection (ICSI).</p> <p>Methods</p> <p>This retrospective study included 534 patients undergoing a fresh cycle of oocyte retrieval and the day-3 embryo transfer (from 22 to 46 years old). Of the 534 patients treated, 331 received a GnRH agonist long stimulation protocol (GnRH agonist group) for ovarian stimulation and 203 patients received a GnRH antagonist protocol (GnRH antagonist group). In each group, patients who had at least one early-cleavage embryo transferred were designated as the 'early-cleavage' subgroup. Patients who had no early-cleavage embryos transferred were designated as the 'late-cleavage' subgroup.</p> <p>Results</p> <p>The early cleavage rate was significantly lower in the GnRH antagonist group compared with that in the GnRH agonist group (IVF cycles: 34% versus 20%; ICSI cycles: 50% versus 37.8%, respectively, P < 0.0001). In the GnRH agonist group, the pregnancy rates were significantly higher in the early-cleavage subgroup than those in the late-cleavage subgroup (53.7% vs 33.9%, <it>P </it>< 0.0001). In the GnRH antagonist group, the pregnancy rates were not significantly different between the early-cleavage and late-cleavage subgroups (45.9% vs 43.8%, P > 0.05).</p> <p>Conclusion</p> <p>Early cleavage of zygote is not a reliable predictor for embryo implantation potential in using the GnRH antagonist protocol. Furthermore, the implantation rates between the GnRH agonist and GnRH antagonist groups were comparable.</p>http://www.rbej.com/content/7/1/20 |
| spellingShingle | Hwu Yuh-Ming Yang Wen-Jui Lee Robert Li Sheng-Hsiang Fleming Steven Early-cleavage is a reliable predictor for embryo implantation in the GnRH agonist protocols but not in the GnRH antagonist protocols Reproductive Biology and Endocrinology |
| title | Early-cleavage is a reliable predictor for embryo implantation in the GnRH agonist protocols but not in the GnRH antagonist protocols |
| title_full | Early-cleavage is a reliable predictor for embryo implantation in the GnRH agonist protocols but not in the GnRH antagonist protocols |
| title_fullStr | Early-cleavage is a reliable predictor for embryo implantation in the GnRH agonist protocols but not in the GnRH antagonist protocols |
| title_full_unstemmed | Early-cleavage is a reliable predictor for embryo implantation in the GnRH agonist protocols but not in the GnRH antagonist protocols |
| title_short | Early-cleavage is a reliable predictor for embryo implantation in the GnRH agonist protocols but not in the GnRH antagonist protocols |
| title_sort | early cleavage is a reliable predictor for embryo implantation in the gnrh agonist protocols but not in the gnrh antagonist protocols |
| url | http://www.rbej.com/content/7/1/20 |
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