Pregnancy outcomes of women who received conservative therapy for endometrial carcinoma or atypical endometrial hyperplasia
Abstract Case Approximately 3%‐25% of cases of endometrial carcinoma (EC) or atypical endometrial hyperplasia (AH) occur in women aged <40 years and conservative treatment with high‐dose medroxyprogesterone acetate (MPA) is administered to women who wish to preserve their fertility. Here is repor...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-07-01
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| Series: | Reproductive Medicine and Biology |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/rmb2.12209 |
| _version_ | 1828400025551503360 |
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| author | Toshiya Matsuzaki Takeshi Iwasa Takako Kawakita Yuri Yamamoto Akiko Abe Aki Hayashi Kiyohito Yano Masato Nishimura Akira Kuwahara Minoru Irahara |
| author_facet | Toshiya Matsuzaki Takeshi Iwasa Takako Kawakita Yuri Yamamoto Akiko Abe Aki Hayashi Kiyohito Yano Masato Nishimura Akira Kuwahara Minoru Irahara |
| author_sort | Toshiya Matsuzaki |
| collection | DOAJ |
| description | Abstract Case Approximately 3%‐25% of cases of endometrial carcinoma (EC) or atypical endometrial hyperplasia (AH) occur in women aged <40 years and conservative treatment with high‐dose medroxyprogesterone acetate (MPA) is administered to women who wish to preserve their fertility. Here is reported the pregnancy outcomes of patients with EC or AH who received MPA therapy at Tokushima University Hospital, Tokushima, Japan. The frequency of pregnancy and live births among the patients with EC or AH who received conservative treatment, followed by fertility treatment, were analyzed retrospectively. Outcome Twelve patients underwent fertility examinations and received fertility treatment immediately after the completion of conservative treatment for EC or AH. One patient had the complication of severe diabetes and total embryo cryopreservation was performed before her diabetes was treated. Among the other 11 patients, 8 (72.7%) became pregnant at least once and 6 (54.5%) experienced at least 1 live birth. Three patients (25.0%) suffered disease recurrence during or after the infertility treatment and all of the recurrences occurred in the EC cohort. Conclusion When patients with EC or AH wish to preserve their fertility, it is recommended that prompt and effective fertility treatment, including assisted reproductive technology, should be initiated just after conservative treatment because EC and AH exhibit relatively high recurrence rates among conservatively treated patients. |
| first_indexed | 2024-12-10T09:25:13Z |
| format | Article |
| id | doaj.art-e7ed8b54ece24fefadf99f38bb766e5d |
| institution | Directory Open Access Journal |
| issn | 1445-5781 1447-0578 |
| language | English |
| last_indexed | 2024-12-10T09:25:13Z |
| publishDate | 2018-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Reproductive Medicine and Biology |
| spelling | doaj.art-e7ed8b54ece24fefadf99f38bb766e5d2022-12-22T01:54:33ZengWileyReproductive Medicine and Biology1445-57811447-05782018-07-0117332532810.1002/rmb2.12209Pregnancy outcomes of women who received conservative therapy for endometrial carcinoma or atypical endometrial hyperplasiaToshiya Matsuzaki0Takeshi Iwasa1Takako Kawakita2Yuri Yamamoto3Akiko Abe4Aki Hayashi5Kiyohito Yano6Masato Nishimura7Akira Kuwahara8Minoru Irahara9Department of Obstetrics and Gynecology Graduate School of Biomedical Sciences Tokushima University Tokushima JapanDepartment of Obstetrics and Gynecology Graduate School of Biomedical Sciences Tokushima University Tokushima JapanDepartment of Obstetrics and Gynecology Graduate School of Biomedical Sciences Tokushima University Tokushima JapanDepartment of Obstetrics and Gynecology Graduate School of Biomedical Sciences Tokushima University Tokushima JapanDepartment of Obstetrics and Gynecology Graduate School of Biomedical Sciences Tokushima University Tokushima JapanDepartment of Obstetrics and Gynecology Shikoku Central Hospital Shikoku City JapanDepartment of Obstetrics and Gynecology Graduate School of Biomedical Sciences Tokushima University Tokushima JapanDepartment of Obstetrics and Gynecology Graduate School of Biomedical Sciences Tokushima University Tokushima JapanDepartment of Obstetrics and Gynecology Graduate School of Biomedical Sciences Tokushima University Tokushima JapanDepartment of Obstetrics and Gynecology Graduate School of Biomedical Sciences Tokushima University Tokushima JapanAbstract Case Approximately 3%‐25% of cases of endometrial carcinoma (EC) or atypical endometrial hyperplasia (AH) occur in women aged <40 years and conservative treatment with high‐dose medroxyprogesterone acetate (MPA) is administered to women who wish to preserve their fertility. Here is reported the pregnancy outcomes of patients with EC or AH who received MPA therapy at Tokushima University Hospital, Tokushima, Japan. The frequency of pregnancy and live births among the patients with EC or AH who received conservative treatment, followed by fertility treatment, were analyzed retrospectively. Outcome Twelve patients underwent fertility examinations and received fertility treatment immediately after the completion of conservative treatment for EC or AH. One patient had the complication of severe diabetes and total embryo cryopreservation was performed before her diabetes was treated. Among the other 11 patients, 8 (72.7%) became pregnant at least once and 6 (54.5%) experienced at least 1 live birth. Three patients (25.0%) suffered disease recurrence during or after the infertility treatment and all of the recurrences occurred in the EC cohort. Conclusion When patients with EC or AH wish to preserve their fertility, it is recommended that prompt and effective fertility treatment, including assisted reproductive technology, should be initiated just after conservative treatment because EC and AH exhibit relatively high recurrence rates among conservatively treated patients.https://doi.org/10.1002/rmb2.12209assisted reproductive technologyatypical endometrial hyperplasiaconservative treatmentendometrial carcinomamedroxyprogesterone acetate |
| spellingShingle | Toshiya Matsuzaki Takeshi Iwasa Takako Kawakita Yuri Yamamoto Akiko Abe Aki Hayashi Kiyohito Yano Masato Nishimura Akira Kuwahara Minoru Irahara Pregnancy outcomes of women who received conservative therapy for endometrial carcinoma or atypical endometrial hyperplasia Reproductive Medicine and Biology assisted reproductive technology atypical endometrial hyperplasia conservative treatment endometrial carcinoma medroxyprogesterone acetate |
| title | Pregnancy outcomes of women who received conservative therapy for endometrial carcinoma or atypical endometrial hyperplasia |
| title_full | Pregnancy outcomes of women who received conservative therapy for endometrial carcinoma or atypical endometrial hyperplasia |
| title_fullStr | Pregnancy outcomes of women who received conservative therapy for endometrial carcinoma or atypical endometrial hyperplasia |
| title_full_unstemmed | Pregnancy outcomes of women who received conservative therapy for endometrial carcinoma or atypical endometrial hyperplasia |
| title_short | Pregnancy outcomes of women who received conservative therapy for endometrial carcinoma or atypical endometrial hyperplasia |
| title_sort | pregnancy outcomes of women who received conservative therapy for endometrial carcinoma or atypical endometrial hyperplasia |
| topic | assisted reproductive technology atypical endometrial hyperplasia conservative treatment endometrial carcinoma medroxyprogesterone acetate |
| url | https://doi.org/10.1002/rmb2.12209 |
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