Bipolar disorder in megalencephalic leukoencephalopathy with subcortical cysts: a case report
Abstract Background Megalencephalic leukoencephalopathy with subcortical cysts (MLC), or Van der Knaap disease, is a rare spongiform leukodystrophy that is characterized by macrocephaly, progressive motor dysfunction, and mild mental retardation. It is very rare for mental illness such as psychotic...
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| Format: | Article |
| Language: | English |
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BMC
2020-07-01
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| Series: | BMC Psychiatry |
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| Online Access: | http://link.springer.com/article/10.1186/s12888-020-02750-6 |
| _version_ | 1818528738983280640 |
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| author | Masanori Ishikawa Yoshie Omachi Noriko Sato Eiji Nakagawa |
| author_facet | Masanori Ishikawa Yoshie Omachi Noriko Sato Eiji Nakagawa |
| author_sort | Masanori Ishikawa |
| collection | DOAJ |
| description | Abstract Background Megalencephalic leukoencephalopathy with subcortical cysts (MLC), or Van der Knaap disease, is a rare spongiform leukodystrophy that is characterized by macrocephaly, progressive motor dysfunction, and mild mental retardation. It is very rare for mental illness such as psychotic disorders, affective disorders and anxiety disorders to occur in MLC. Case presentation A 17-year-old boy was admitted to our hospital after he developed symptoms of depressive state with catatonia after being diagnosed as having MLC with confirmed MLC1 mutation. His catatonic symptoms were improved with administration of olanzapine and sertraline and he was discharged after 4 months. Several months later, he became hypomanic. He was diagnosed with bipolar II disorder. Mood swings were controlled with the administration of carbamazepine. Conclusions This case is the first report of bipolar disorder during the clinical course of MLC. This case indicate the possibility that MLC influences the development of bipolar disorder in MLC, however, further studies involving more patients are required to clarify this. |
| first_indexed | 2024-12-11T06:53:54Z |
| format | Article |
| id | doaj.art-e7f18b28754044f788a394df257d389c |
| institution | Directory Open Access Journal |
| issn | 1471-244X |
| language | English |
| last_indexed | 2024-12-11T06:53:54Z |
| publishDate | 2020-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj.art-e7f18b28754044f788a394df257d389c2022-12-22T01:16:49ZengBMCBMC Psychiatry1471-244X2020-07-012011610.1186/s12888-020-02750-6Bipolar disorder in megalencephalic leukoencephalopathy with subcortical cysts: a case reportMasanori Ishikawa0Yoshie Omachi1Noriko Sato2Eiji Nakagawa3Department of Social Welfare Service, Faculty of Human Sciences, Mejiro UniversityDepartment of Psychiatry, National Center Hospital of Neurology and Psychiatry, National Center of Neurology and PsychiatryDepartment of Radiology, National Center Hospital of Neurology and Psychiatry, National Center of Neurology and PsychiatryDepartment of Child Neurology, National Center Hospital of Neurology and Psychiatry, National Center of Neurology and PsychiatryAbstract Background Megalencephalic leukoencephalopathy with subcortical cysts (MLC), or Van der Knaap disease, is a rare spongiform leukodystrophy that is characterized by macrocephaly, progressive motor dysfunction, and mild mental retardation. It is very rare for mental illness such as psychotic disorders, affective disorders and anxiety disorders to occur in MLC. Case presentation A 17-year-old boy was admitted to our hospital after he developed symptoms of depressive state with catatonia after being diagnosed as having MLC with confirmed MLC1 mutation. His catatonic symptoms were improved with administration of olanzapine and sertraline and he was discharged after 4 months. Several months later, he became hypomanic. He was diagnosed with bipolar II disorder. Mood swings were controlled with the administration of carbamazepine. Conclusions This case is the first report of bipolar disorder during the clinical course of MLC. This case indicate the possibility that MLC influences the development of bipolar disorder in MLC, however, further studies involving more patients are required to clarify this.http://link.springer.com/article/10.1186/s12888-020-02750-6Megalencephalic leukoencephalopathy with subcortical cystsMLC1Bipolar II disorderCatatonia |
| spellingShingle | Masanori Ishikawa Yoshie Omachi Noriko Sato Eiji Nakagawa Bipolar disorder in megalencephalic leukoencephalopathy with subcortical cysts: a case report BMC Psychiatry Megalencephalic leukoencephalopathy with subcortical cysts MLC1 Bipolar II disorder Catatonia |
| title | Bipolar disorder in megalencephalic leukoencephalopathy with subcortical cysts: a case report |
| title_full | Bipolar disorder in megalencephalic leukoencephalopathy with subcortical cysts: a case report |
| title_fullStr | Bipolar disorder in megalencephalic leukoencephalopathy with subcortical cysts: a case report |
| title_full_unstemmed | Bipolar disorder in megalencephalic leukoencephalopathy with subcortical cysts: a case report |
| title_short | Bipolar disorder in megalencephalic leukoencephalopathy with subcortical cysts: a case report |
| title_sort | bipolar disorder in megalencephalic leukoencephalopathy with subcortical cysts a case report |
| topic | Megalencephalic leukoencephalopathy with subcortical cysts MLC1 Bipolar II disorder Catatonia |
| url | http://link.springer.com/article/10.1186/s12888-020-02750-6 |
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