An anaerobic bacterium host system for heterologous expression of natural product biosynthetic gene clusters
Anaerobic bacteria represent a rich source of biological and chemical diversity but are difficult to cultivate and there is a lack of heterologous expression systems. Here the authors develop an expression system based on S. mutans UA159 for biosynthetic gene clusters from anaerobic bacteria.
Bibliographic Details
| Main Authors: |
Tingting Hao,
Zhoujie Xie,
Min Wang,
Liwei Liu,
Yuwei Zhang,
Weicang Wang,
Zhao Zhang,
Xuejin Zhao,
Pengwei Li,
Zhengyan Guo,
Shushan Gao,
Chunbo Lou,
Guodong Zhang,
Justin Merritt,
Geoff P. Horsman,
Yihua Chen |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2019-08-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-019-11673-0
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