Dendritic Cells Expressing MyD88 Molecule Are Necessary and Sufficient for CpG-Mediated Inhibition of IgE Production In Vivo

Dendritic Cells Expressing MyD88 Molecule Are Necessary and Sufficient for CpG-Mediated Inhibition of IgE Production In Vivo

Elevated levels of immunoglobulin E (IgE) are associated with allergies and other immunological disorders. Sensitization with alum adjuvant favours IgE production while CpG-ODN adjuvant, a synthetic toll-like receptor 9 (TLR9) agonist, inhibits it. The cellular mechanisms underlying in vivo TLR regu...

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Bibliographic Details
Main Authors: Ricardo W. Alberca Custodio, Luciana Mirotti, Eliane Gomes, Fernanda P.B. Nunes, Raquel S. Vieira, Luís Graça, Rafael R. Almeida, Niels O. S. Câmara, Momtchilo Russo
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Cells
Subjects:
allergy
ige
igg2c
anaphylaxis
dendritic cells
Online Access:https://www.mdpi.com/2073-4409/8/10/1165

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