Rapid generation of a mouse model for evaluating on-target normal tissue toxicity of human CAR-T cells using replication-defective recombinant adenovirus

Rapid generation of a mouse model for evaluating on-target normal tissue toxicity of human CAR-T cells using replication-defective recombinant adenovirus

Introduction: The on-target off-tumor toxicity of chimeric antigen receptor-engineered T cells (CAR-T) might lead to fatal side effects in cancer patients, which remains as a major obstacle to the clinical application of CAR-T immunotherapy. The off-tumor on-target normal tissue toxicity of CAR-T ce...

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Bibliographic Details
Main Authors: Qibin Liao, Zhuoqun Liu, Cuisong Zhu, Huan He, Meiqi Feng, Lang Jiang, Xiangqing Ding, Rongxun Sun, Xiaoyan Zhang, Jianqing Xu
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Journal of Advanced Research
Subjects:
CAR-T
On-target off-tumor toxicity
Normal tissue
Animal model
Adenovirus
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123222001898

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