Glycosaminoglycans and fucoidan have a protective effect on experimental glomerulonephritis

Glycosaminoglycans and fucoidan have a protective effect on experimental glomerulonephritis

Background: The glomerular endothelial glycocalyx is degraded during inflammation. The glycocalyx plays a pivotal role in endothelial function and is involved in many processes including binding of chemokines and cytokines, leukocyte trafficking, and preventing proteinuria. HS-based therapeutics are...

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Bibliographic Details
Main Authors: Baranca Buijsers, Marissa Maciej-Hulme, Maaike Jacobs, Marinka Bakker-van Bebber, Mark de Graaf, Rustem Salmenov, Naomi Parr, Ton J. Rabelink, Tom Nijenhuis, Johan van der Vlag
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Molecular Biosciences
Subjects:
glycosaminoglycans
heparan sulfate
fucoidan
sulodexide
endothelial glycocalyx
heparanase-1
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2023.1223972/full

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https://www.frontiersin.org/articles/10.3389/fmolb.2023.1223972/full

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