Inhibition of Sphingosine-1-Phosphate Receptor 2 Prevents Thoracic Aortic Dissection and Rupture

Inhibition of Sphingosine-1-Phosphate Receptor 2 Prevents Thoracic Aortic Dissection and Rupture

Background: Numerous pieces of evidence have indicated that thoracic aortic dissection (TAD) is an inflammatory disease. Sphingosine-1-phosphate receptor 2 (S1PR2) signaling is a driver in multiple inflammatory diseases. Here, we examined the S1PR2 expression in TAD lesions and explored the effect o...

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Bibliographic Details
Main Authors: Guangwei Pan, Mengyang Liao, Yong Dai, Yang Li, Xiaole Yan, Wuqian Mai, Jinping Liu, Yuhua Liao, Zhihua Qiu, Zihua Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
thoracic aortic dissection
S1PR2 inhibition
JTE013
inflammation
neutrophil extracellular traps
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.748486/full

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