Osteosarcoma Cell-Derived Exosomal ELFN1-AS1 Mediates Macrophage M2 Polarization via Sponging miR-138-5p and miR-1291 to Promote the Tumorgenesis of Osteosarcoma

Osteosarcoma Cell-Derived Exosomal ELFN1-AS1 Mediates Macrophage M2 Polarization via Sponging miR-138-5p and miR-1291 to Promote the Tumorgenesis of Osteosarcoma

BackgroundExosomes play an important role in cell-cell communication by transferring genetic materials such as long non-coding RNAs (lncRNAs) between cancer cells and tumor-associated macrophages (TAMs) in the tumor microenvironment (TME). Recent studies revealed that lncRNA ELFN1-AS1 could function...

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Bibliographic Details
Main Authors: Bangmin Wang, Xin Wang, Po Li, Xiaoying Niu, Xiaoxiao Liang, Guancong Liu, Zhiyong Liu, Hong Ge
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Oncology
Subjects:
tumor microenvironment
tumor-associated macrophages
exosomes
long noncoding RNAs
osteosarcoma
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.881022/full

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