| Summary: | This work presents the preliminary development of paroxetine-based formulations containing hydroxypropylcellulose (HPC) polymers suitable for hot-melt extrusion coupled to fused deposition modeling (3D printing). Two grades of HPC (54% <i>w</i>/<i>w</i>), Klucel<sup>TM</sup> LF and Klucel<sup>TM</sup> GF, were tested in a polymeric formulation of paroxetine (30% <i>w</i>/<i>w</i>) and adjuvants (16% <i>w</i>/<i>w</i> of dicalcium dihydrate phosphate, magnesium stearate, and triethylcitrate; 10:1:5 ratio). Both formulations exhibited a release of almost 100% of paroxetine after 12 h, but the drug released from the Klucel<sup>TM</sup> LF formulation was quicker and closer to the formulations available in the market.
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