Selection of a Hydroxypropylcellulose Grade for 3D-Printable Paroxetine Formulations by Fused Deposition Modelling
This work presents the preliminary development of paroxetine-based formulations containing hydroxypropylcellulose (HPC) polymers suitable for hot-melt extrusion coupled to fused deposition modeling (3D printing). Two grades of HPC (54% <i>w</i>/<i>w</i>), Klucel<sup>TM&...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Medical Sciences Forum |
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| Online Access: | https://www.mdpi.com/2673-9992/22/1/17 |
| _version_ | 1827725025800617984 |
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| author | Sara Figueiredo João F. Pinto Fátima G. Carvalho Ana I. Fernandes |
| author_facet | Sara Figueiredo João F. Pinto Fátima G. Carvalho Ana I. Fernandes |
| author_sort | Sara Figueiredo |
| collection | DOAJ |
| description | This work presents the preliminary development of paroxetine-based formulations containing hydroxypropylcellulose (HPC) polymers suitable for hot-melt extrusion coupled to fused deposition modeling (3D printing). Two grades of HPC (54% <i>w</i>/<i>w</i>), Klucel<sup>TM</sup> LF and Klucel<sup>TM</sup> GF, were tested in a polymeric formulation of paroxetine (30% <i>w</i>/<i>w</i>) and adjuvants (16% <i>w</i>/<i>w</i> of dicalcium dihydrate phosphate, magnesium stearate, and triethylcitrate; 10:1:5 ratio). Both formulations exhibited a release of almost 100% of paroxetine after 12 h, but the drug released from the Klucel<sup>TM</sup> LF formulation was quicker and closer to the formulations available in the market. |
| first_indexed | 2024-03-10T22:23:40Z |
| format | Article |
| id | doaj.art-e7f6e16c963d4dbe9c71564d71b18725 |
| institution | Directory Open Access Journal |
| issn | 2673-9992 |
| language | English |
| last_indexed | 2024-03-10T22:23:40Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medical Sciences Forum |
| spelling | doaj.art-e7f6e16c963d4dbe9c71564d71b187252023-11-19T12:12:42ZengMDPI AGMedical Sciences Forum2673-99922023-08-012211710.3390/msf2023022017Selection of a Hydroxypropylcellulose Grade for 3D-Printable Paroxetine Formulations by Fused Deposition ModellingSara Figueiredo0João F. Pinto1Fátima G. Carvalho2Ana I. Fernandes3iMed.ULisboa—Research Institute for Medicines, Faculdade de Farmácia, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, PortugaliMed.ULisboa—Research Institute for Medicines, Faculdade de Farmácia, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, PortugalInfosaúde—Laboratório de Estudos Farmacêuticos, R. Ferrarias Del Rei 6A, 2730-036 Barcarena, PortugalEgas Moniz Center for Interdisciplinary Research (CiiEM), Egas Moniz School of Health & Science, 2829-511 Almada, PortugalThis work presents the preliminary development of paroxetine-based formulations containing hydroxypropylcellulose (HPC) polymers suitable for hot-melt extrusion coupled to fused deposition modeling (3D printing). Two grades of HPC (54% <i>w</i>/<i>w</i>), Klucel<sup>TM</sup> LF and Klucel<sup>TM</sup> GF, were tested in a polymeric formulation of paroxetine (30% <i>w</i>/<i>w</i>) and adjuvants (16% <i>w</i>/<i>w</i> of dicalcium dihydrate phosphate, magnesium stearate, and triethylcitrate; 10:1:5 ratio). Both formulations exhibited a release of almost 100% of paroxetine after 12 h, but the drug released from the Klucel<sup>TM</sup> LF formulation was quicker and closer to the formulations available in the market.https://www.mdpi.com/2673-9992/22/1/17hydroxypropylcellulose (HPC) gradeparoxetine (PRX)printability3D-printed tabletfused deposition modelling (FDM)hot-melt extrusion (HME) |
| spellingShingle | Sara Figueiredo João F. Pinto Fátima G. Carvalho Ana I. Fernandes Selection of a Hydroxypropylcellulose Grade for 3D-Printable Paroxetine Formulations by Fused Deposition Modelling Medical Sciences Forum hydroxypropylcellulose (HPC) grade paroxetine (PRX) printability 3D-printed tablet fused deposition modelling (FDM) hot-melt extrusion (HME) |
| title | Selection of a Hydroxypropylcellulose Grade for 3D-Printable Paroxetine Formulations by Fused Deposition Modelling |
| title_full | Selection of a Hydroxypropylcellulose Grade for 3D-Printable Paroxetine Formulations by Fused Deposition Modelling |
| title_fullStr | Selection of a Hydroxypropylcellulose Grade for 3D-Printable Paroxetine Formulations by Fused Deposition Modelling |
| title_full_unstemmed | Selection of a Hydroxypropylcellulose Grade for 3D-Printable Paroxetine Formulations by Fused Deposition Modelling |
| title_short | Selection of a Hydroxypropylcellulose Grade for 3D-Printable Paroxetine Formulations by Fused Deposition Modelling |
| title_sort | selection of a hydroxypropylcellulose grade for 3d printable paroxetine formulations by fused deposition modelling |
| topic | hydroxypropylcellulose (HPC) grade paroxetine (PRX) printability 3D-printed tablet fused deposition modelling (FDM) hot-melt extrusion (HME) |
| url | https://www.mdpi.com/2673-9992/22/1/17 |
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