Heterogeneity of multiple sclerosis lesions in fast diffusional kurtosis imaging.
<h4>Background</h4>Mean kurtosis (MK), one of the parameters derived from diffusion kurtosis imaging (DKI), has shown increased sensitivity to tissue microstructure damage in several neurological disorders.<h4>Methods</h4>Thirty-seven patients with relapsing-remitting MS and...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2021-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0245844 |
| _version_ | 1818743210770432000 |
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| author | Christian Thaler Anna A Kyselyova Tobias D Faizy Marie T Nawka Sune Jespersen Brian Hansen Jan-Patrick Stellmann Christoph Heesen Klarissa H Stürner Maria Stark Jens Fiehler Maxim Bester Susanne Gellißen |
| author_facet | Christian Thaler Anna A Kyselyova Tobias D Faizy Marie T Nawka Sune Jespersen Brian Hansen Jan-Patrick Stellmann Christoph Heesen Klarissa H Stürner Maria Stark Jens Fiehler Maxim Bester Susanne Gellißen |
| author_sort | Christian Thaler |
| collection | DOAJ |
| description | <h4>Background</h4>Mean kurtosis (MK), one of the parameters derived from diffusion kurtosis imaging (DKI), has shown increased sensitivity to tissue microstructure damage in several neurological disorders.<h4>Methods</h4>Thirty-seven patients with relapsing-remitting MS and eleven healthy controls (HC) received brain imaging on a 3T MR scanner, including a fast DKI sequence. MK and mean diffusivity (MD) were measured in the white matter of HC, normal-appearing white matter (NAWM) of MS patients, contrast-enhancing lesions (CE-L), FLAIR lesions (FLAIR-L) and black holes (BH).<h4>Results</h4>Overall 1529 lesions were analyzed, including 30 CE-L, 832 FLAIR-L and 667 BH. Highest MK values were obtained in the white matter of HC (0.814 ± 0.129), followed by NAWM (0.724 ± 0.137), CE-L (0.619 ± 0.096), FLAIR-L (0.565 ± 0.123) and BH (0.549 ± 0.12). Lowest MD values were obtained in the white matter of HC (0.747 ± 0.068 10-3mm2/sec), followed by NAWM (0.808 ± 0.163 10-3mm2/sec), CE-L (0.853 ± 0.211 10-3mm2/sec), BH (0.957 ± 0.304 10-3mm2/sec) and FLAIR-L (0.976 ± 0.35 10-3mm2/sec). While MK differed significantly between CE-L and non-enhancing lesions, MD did not.<h4>Conclusion</h4>MK adds predictive value to differentiate between MS lesions and might provide further information about diffuse white matter injury and lesion microstructure. |
| first_indexed | 2024-12-18T02:24:48Z |
| format | Article |
| id | doaj.art-e7f6e6650c6b460587aa9fe560f68c01 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-18T02:24:48Z |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-e7f6e6650c6b460587aa9fe560f68c012022-12-21T21:24:05ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-01162e024584410.1371/journal.pone.0245844Heterogeneity of multiple sclerosis lesions in fast diffusional kurtosis imaging.Christian ThalerAnna A KyselyovaTobias D FaizyMarie T NawkaSune JespersenBrian HansenJan-Patrick StellmannChristoph HeesenKlarissa H StürnerMaria StarkJens FiehlerMaxim BesterSusanne Gellißen<h4>Background</h4>Mean kurtosis (MK), one of the parameters derived from diffusion kurtosis imaging (DKI), has shown increased sensitivity to tissue microstructure damage in several neurological disorders.<h4>Methods</h4>Thirty-seven patients with relapsing-remitting MS and eleven healthy controls (HC) received brain imaging on a 3T MR scanner, including a fast DKI sequence. MK and mean diffusivity (MD) were measured in the white matter of HC, normal-appearing white matter (NAWM) of MS patients, contrast-enhancing lesions (CE-L), FLAIR lesions (FLAIR-L) and black holes (BH).<h4>Results</h4>Overall 1529 lesions were analyzed, including 30 CE-L, 832 FLAIR-L and 667 BH. Highest MK values were obtained in the white matter of HC (0.814 ± 0.129), followed by NAWM (0.724 ± 0.137), CE-L (0.619 ± 0.096), FLAIR-L (0.565 ± 0.123) and BH (0.549 ± 0.12). Lowest MD values were obtained in the white matter of HC (0.747 ± 0.068 10-3mm2/sec), followed by NAWM (0.808 ± 0.163 10-3mm2/sec), CE-L (0.853 ± 0.211 10-3mm2/sec), BH (0.957 ± 0.304 10-3mm2/sec) and FLAIR-L (0.976 ± 0.35 10-3mm2/sec). While MK differed significantly between CE-L and non-enhancing lesions, MD did not.<h4>Conclusion</h4>MK adds predictive value to differentiate between MS lesions and might provide further information about diffuse white matter injury and lesion microstructure.https://doi.org/10.1371/journal.pone.0245844 |
| spellingShingle | Christian Thaler Anna A Kyselyova Tobias D Faizy Marie T Nawka Sune Jespersen Brian Hansen Jan-Patrick Stellmann Christoph Heesen Klarissa H Stürner Maria Stark Jens Fiehler Maxim Bester Susanne Gellißen Heterogeneity of multiple sclerosis lesions in fast diffusional kurtosis imaging. PLoS ONE |
| title | Heterogeneity of multiple sclerosis lesions in fast diffusional kurtosis imaging. |
| title_full | Heterogeneity of multiple sclerosis lesions in fast diffusional kurtosis imaging. |
| title_fullStr | Heterogeneity of multiple sclerosis lesions in fast diffusional kurtosis imaging. |
| title_full_unstemmed | Heterogeneity of multiple sclerosis lesions in fast diffusional kurtosis imaging. |
| title_short | Heterogeneity of multiple sclerosis lesions in fast diffusional kurtosis imaging. |
| title_sort | heterogeneity of multiple sclerosis lesions in fast diffusional kurtosis imaging |
| url | https://doi.org/10.1371/journal.pone.0245844 |
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