pH-dependent interactions of coacervate-forming histidine-rich peptide with model lipid membranes

pH-dependent interactions of coacervate-forming histidine-rich peptide with model lipid membranes

Peptide-based liquid droplets (coacervates) produced by spontaneous liquid-liquid phase separation (LLPS), have emerged as a promising class of drug delivery systems due to their high entrapping efficiency and the simplicity of their formulation. However, the detailed mechanisms governing their inte...

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Bibliographic Details
Main Authors: Sushanth Gudlur, Filipe Viana Ferreira, Javier Shu Ming Ting, Carmen Domene, Syed Maricar, Anton P. Le Brun, Nageshwar Yepuri, Michael Moir, Robert Russell, Tamim Darwish, Ali Miserez, Marité Cárdenas
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Soft Matter
Subjects:
LLPS
peptide coacervates
neutron reflectivity
membrane interaction
model membrane
molecular dynamic simulations
Online Access:https://www.frontiersin.org/articles/10.3389/frsfm.2023.1339496/full

Internet

https://www.frontiersin.org/articles/10.3389/frsfm.2023.1339496/full

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